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Application of injectable hydrogel in preparing intraocular filling materials

A technology for injecting water and fillers, which is applied in medical preparations with non-active ingredients, medical science, prostheses, etc., and can solve problems such as lack of vitreous fillers, small molecule cross-linking agents that cannot be removed, side effects of eye tissue cells, etc. Achieve good biocompatibility and biosafety in the eye, reduce the number of medications, and have no toxic and side effects

Active Publication Date: 2016-08-10
QINGDAO HUISHENG HUIZHONG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hyaluronic acid has good biocompatibility, the introduction of small molecule cross-linking agents cannot be removed in the eye, and there are certain side effects on eye tissue cells after being absorbed by eye tissue
Therefore, there is currently a lack of ideal vitreous fillers in clinical practice.

Method used

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  • Application of injectable hydrogel in preparing intraocular filling materials
  • Application of injectable hydrogel in preparing intraocular filling materials
  • Application of injectable hydrogel in preparing intraocular filling materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Preparation of oxidized chondroitin sulfate

[0021] Weigh 12.0g of chondroitin sulfate, add it to a 500ml glass Erlenmeyer flask, add 200ml of water, stir to dissolve, adjust the pH value to pH5.0 with 1mol / L hydrochloric acid aqueous solution, add the oxidant NaIO 4 1g, sealed, stirred and oxidized for 18h at 4°C in the dark. After the reaction, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Daltons, and the solution was dialyzed against light and distilled water at 4° C. for 24 hours, and the distilled water was replaced every 6 hours. After the dialysis, the liquid in the dialysis bag was freeze-dried in a freeze dryer for 48 hours to obtain 11.3 g of oxychondroitin sulfate containing dialdehyde groups, with a dialdehyde group percentage of 2.5% (dialdehyde group percentage is Refers to the percentage of sugar units containing dialdehyde groups in the polysaccharide molecule to the total sugar units of the polysacc...

Embodiment 2

[0022] Example 2: Preparation of oxidized starch

[0023] Weigh 15g starch, add it to a 500ml glass Erlenmeyer flask, add 200ml water, heat and stir to dissolve, adjust the pH value to pH 5.5 with 5% (weight percentage, the same below) aqueous acetic acid solution, add the oxidant NaIO 4 3.5g, sealed, stirred and oxidized at room temperature for 24h in the dark. After the reaction, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Daltons, and the solution was dialyzed against light and distilled water at 4° C. for 24 hours, and the distilled water was replaced every 6 hours. After the dialysis, the liquid in the dialysis bag was freeze-dried in a freeze dryer for 48 hours to obtain 13.5 g of oxidized starch containing dialdehyde groups, with a dialdehyde group percentage of 12.5%.

Embodiment 3

[0024] Example 3: Preparation of oxidized hyaluronic acid

[0025] Weigh 5g of hyaluronic acid, add it to a 1000ml glass Erlenmeyer flask, add 500ml of water, stir to dissolve, adjust the pH value to pH 5.5 with 5% (weight percentage, the same below) aqueous acetic acid solution, add the oxidant NaIO 4 2.5g, sealed, stirred and oxidized at room temperature in the dark for 24h. After the reaction, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Daltons, and the solution was dialyzed against light and distilled water at 4° C. for 24 hours, and the distilled water was replaced every 6 hours. After the dialysis, the liquid in the dialysis bag was freeze-dried in a freeze dryer for 48 hours to obtain 3.9 g of oxidized hyaluronic acid containing dialdehyde groups, with a dialdehyde group percentage of 30.8%.

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Abstract

The invention discloses an application of injectable hydrogel in preparing intraocular filling materials. The application is characterized by being application of the injectable hydrogel as intraocular filling materials in vitreoretinal surgery as well as application of the injectable hydrogel as an intraocular drug carrier, wherein the injectable hydrogel is composed of two agents; the first agent is a glue solution containing oxidized polysaccharide; the second agent is a glue solution containing a chitin derivative and / or collagen; the two agents are separately contained in two injection tubes of a duplicate injector; the two glue solutions are simultaneously pushed and injected by the duplicate injector; in the pushing and injecting process, mixing and cross-linking are generated, namely, a dialdehyde group of the oxidized polysaccharide generates cross-linking reaction with amino of the chitin derivative and / or the collagen to form hydrogel with viscoelasticity. The constituents of the hydrogel are biomacromolecules different from chemical macromolecules, and a micromolecule cross-linking agent is not introduced, so that the biocompatibility is good, the hydrogel can be degraded and absorbed, toxic and side effects are avoided, and the safety is good.

Description

technical field [0001] The invention relates to an ophthalmic medical product, in particular to the application of an injectable hydrogel in the preparation of intraocular fillings. Background technique [0002] The vitreous body is a colorless transparent jelly in the cavity at the back of the eyeball. It fills between the lens and the retina and occupies more than 2 / 3 of the eyeball volume. Its main components include water, collagen, hyaluronic acid, and proteoglycans. wait. The vitreous provides proper support for the retina, protects surrounding ocular tissues, enables light to reach receptors at the back of the eye, regulates intraocular oxygen levels and eye shape, and allows for the diffuse transport of metabolites and other solutes. Vitrectomy is an important eye surgery used to treat eye diseases such as retinopathy and retinal detachment. With the development of vitreous surgery technology, its scope of indications has been expanding. Vitrectomy requires fillin...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/24A61L27/52A61K47/36
CPCA61K47/36A61L27/20A61L27/24A61L27/52A61L2430/16C08L89/00C08L3/10C08L5/08C08L5/04C08L1/286
Inventor 刘万顺杨朝忠
Owner QINGDAO HUISHENG HUIZHONG BIOLOGICAL TECH CO LTD
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