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External-use drug for treating osseous metastasis cancer pain and preparation method of external-use drug

A technology for external use of drugs and bone metastases, which can be applied to medical preparations containing active ingredients, drug combinations, drug delivery, etc. , The process of skin absorption and diffusion is shortened, and the effect of inhibiting the growth of tumor cells

Inactive Publication Date: 2016-08-17
TCM HOSPITAL CHANGXING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the problems of weak analgesic effect and short duration of curative effect in the prior art, the present invention provides a medicine for external use for treating bone metastatic cancer pain and a preparation method thereof

Method used

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  • External-use drug for treating osseous metastasis cancer pain and preparation method of external-use drug
  • External-use drug for treating osseous metastasis cancer pain and preparation method of external-use drug

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Bone metastatic cancer is a common metastatic cancer. Its primary site can be anywhere in the body, and it can spread to bone through lymph or blood, and it mostly occurs in the elderly. Traditional Western medicine treatment methods are mostly aimed at relieving the pain of patients, but the long-term efficacy is not good, and the side effects are relatively large. Moreover, most patients with bone metastases are weak in physical strength and cannot tolerate the toxic and side effects brought by chemotherapy, radiotherapy and other treatment methods. Moreover, most bone metastases are discovered at an advanced stage, with poor prognosis, and most of them cannot be cured. Therefore, it is an urgent need in the current medical field to seek a method for treating bone metastases with high cure rate and little toxic and side effects.

[0022] The invention discloses an external medicine for treating bone metastatic cancer pain, which comprises the following components: Scu...

Embodiment 2

[0054] On the basis of Example 1, this embodiment discloses a preparation method of an external drug for the treatment of bone metastatic cancer pain. Preferably, the external drug is in the form of a medicinal liquid; preparing the liquid composition includes the following steps: mixing the above-mentioned Scutellaria barbata , Solanum nigrum, Mylabris, Corydalis, Curcuma 20g each, green skin 15g, white snake 2, centipede 5, scorpion 5, three-edged 15g, borneol, asarum 10g each; sort them out and put them in a 5L glass container , put into 1500mL of 75% alcohol for soaking, seal and soak for 7 days at natural temperature to prepare the medicinal solution.

[0055] Among them, the white-flowered snake is the dried whole body of Agkistrodon acarina (Sintrapedidae), a Viper family animal.

[0056] The centipede is the dry body of Scolopendra subspinipes mutilans L. Koch, a centipede animal with few spines. Spring and summer catches. Insert the head and tail with bamboo slices,...

Embodiment 3

[0060] On the basis of Example 2, in another embodiment, this embodiment discloses a preparation method of an external drug for the treatment of bone metastatic cancer pain. Preferably, the external drug is in the form of a paste; the preparation steps of the ointment are as follows : Each 30g of the above-mentioned Scutellaria barbata, Solanum nigrum, Mylabris, Yanhusuo, and Curcuma, 15g of green skin, 2 white snakes, 5 centipedes, 5 scorpions, 15g of triangular edges, 10g of borneol, and Asarum; sort them out separately Then put it in a 5L glass container, put it into 1500mL of 75% alcohol for soaking, seal and soak it at natural temperature for 7 days, and prepare the medicinal liquid; put half of the prepared liquid component and 100-200 parts by weight of vegetable oil in the same pot For frying, the weight of the vegetable oil used is 40-60% of the weight of the liquid component. The amount of vegetable oil is very critical. In the process of preparing the plaster, the d...

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Abstract

The invention provides an external-use drug for treating osseous metastasis cancer pain and a preparation method of the external-use drug. The external-use drug comprises scutellaria barbata, black nightshade, cantharides, rhizoma corydalis, curcuma zedoary, pericarpium citri reticulatae viride, long-noded pit vipers, centipedes, scorpions, rhizoma sparganii, borneol and asarum. The contents of the scutellaria barbata, the black nightshade, the cantharides, the rhizoma sparganii and the curcuma zedoary are the same and are highest. The contents of the pericarpium citri reticulatae viride and the rhizoma sparganii are the same. The contents of the borneol and the asarum are the same and are lowest. The external-use drug has the advantages that multiple proper amounts of Chinese herbs are matched mutually and used jointly for treatment coordination, and accordingly, the curative effect of obviously relieving the osseous metastasis cancer pain can be achieved; the preparation method is simple, the external-use drug can be made into liquid, the liquid can be also made into a plaster for external application, the dosage form of the drug can be flexible and changeable, and accordingly, needs of different patients can be met.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine components, in particular to an externally used medicine for treating bone metastatic cancer pain and a preparation method thereof, which has the effect of relieving and treating the bone metastatic pain of cancer patients. Background technique [0002] The most common symptom of bone metastases is pain, which is one of the most painful clinical symptoms for patients. Severe pain caused by bone metastasis affects the curative effect of comprehensive tumor treatment, seriously affects the quality of life of patients, and even endangers their lives, which brings a heavy burden to families and society. Therefore, actively looking for effective means of treating bone metastases is one of the important topics in palliative treatment of tumors, and it is also an urgent problem to be solved in clinical work. The pain mechanism of bone metastases is complex. First, because the tumor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/04A61P29/00A61K31/045A61K35/64A61K35/646A61K35/648A61K35/583
CPCA61K36/902A61K36/9066A61K9/0014A61K31/045A61K35/583A61K35/63A61K35/646A61K35/648A61K36/268A61K36/539A61K36/66A61K36/752A61K36/81A61K2236/333A61K2300/00
Inventor 饶爱华
Owner TCM HOSPITAL CHANGXING
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