Method for self-assembling and synthesizing spherical gold nanoparticles by using bacitracin as template

A technology for self-assembly of gold nanoparticles and templates, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc. Clear amino acid sequence, simple preparation method and green reaction conditions

Active Publication Date: 2016-08-24
YANSHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Physical methods, such as: high-energy ball milling method, vacuum evaporation indigo polymerization method, etc., the preparation process has high requirements on equipment, the product purity is low, the shape is difficult to control, and the obtained particle size distribution is very wide; chemical methods, such as: sol -Gel method, chemical vapor deposition, etc. Most of the nanomaterials pre

Method used

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  • Method for self-assembling and synthesizing spherical gold nanoparticles by using bacitracin as template
  • Method for self-assembling and synthesizing spherical gold nanoparticles by using bacitracin as template
  • Method for self-assembling and synthesizing spherical gold nanoparticles by using bacitracin as template

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 0.5mg of bacitracin (Hubei Haiyi Pharmaceutical Chemical Co., Ltd.), and dissolve it in 1mL of pH 3 hydrochloric acid solution to prepare a 0.35mM bacitracin solution; take 200mL of the above bacitracin solution and heat-treat it in a metal bath at 40°C for 1h , and then ultrasonic treatment for 30s, the ultrasonic frequency is 50Hz; the treated bacitracin solution was mixed with 200mL 2mM AuCl 3 The solution (Shanghai West Asia Reagent Co., Ltd.) was mixed; the above-mentioned mixed solution was placed in a double-layer gas shaker, incubated at 100rmp, 20°C for 20h, and then 4mM reducing agent sodium borohydride (Tianjin Guangfu Fine Chemical Research Institute) was added. 60mL was reduced, the dropping rate was 1 drop / min, 30mL / drop, the reaction temperature was controlled at 21°C, and the reaction was carried out for 40min. The color of the solution slowly changed from golden yellow to blue-gray, and bacitracin-spherical gold nanoparticles were obtained.

[0023...

Embodiment 2

[0025] Take 0.75mg of bacitracin (Hubei Haiyi Pharmaceutical Chemical Co., Ltd.), and dissolve it in 1mL of hydrochloric acid solution with pH 3.5 to obtain a 0.53mM bacitracin solution; take 200mL of the above-mentioned bacitracin solution and heat-treat it in a metal bath at 50°C for 1.5 h, and then ultrasonic treatment for 30s, the ultrasonic frequency is 50Hz; the treated bacitracin solution was mixed with 200mL of 4mM 3 The solution (Shanghai West Asia Reagent Co., Ltd.) was mixed; the above-mentioned mixed solution was placed in a double-layer gas shaker, incubated at 125rmp and 22°C for 25h, and then 5mM reducing agent sodium borohydride (Tianjin Guangfu Fine Chemical Research Institute) was added. 60mL was reduced, the dropping rate was 1 drop / min, 30mL / drop, the reaction temperature was controlled at 22°C, and the reaction was carried out for 50min. The color of the solution slowly changed from golden yellow to blue-gray, and bacitracin-spherical gold nanoparticles wer...

Embodiment 3

[0028] Take 1.0mg of bacitracin (Hubei Haiyi Pharmaceutical Chemical Co., Ltd.), and dissolve it in 1mL of pH 4 hydrochloric acid solution to prepare a 0.70mM bacitracin solution; take 200mL of the above bacitracin solution and heat-treat it in a metal bath at 60°C for 2h , and then ultrasonic treatment for 30s, the ultrasonic frequency is 50Hz; the treated bacitracin solution was mixed with 200mL 6mM AuCl 3 The solution (Shanghai West Asia Reagent Co., Ltd.) was mixed; the above-mentioned mixed solution was placed in an air bath shaker, incubated at 150rmp and 25°C for 30h, and then 6mM reducing agent sodium borohydride (Tianjin Guangfu Fine Chemical Research Institute) was added. ) 90mL for reduction, the dropping rate was 2 drops / min, 30mL / drop, the reaction temperature was controlled at 23°C, and the reaction was carried out for 60min. The color of the solution slowly changed from golden yellow to blue-gray, and bacitracin-gold nanoparticles were obtained.

[0029] Such as...

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Abstract

A method for self-assembling and synthesizing spherical gold nanoparticles by using bacitracin as a template mainly comprises the following steps: feeding bacitracin into a hydrochloric acid solution to obtain 0.35 to 0.70mM acidic bacitracin solution, then thermally processing the acidic bacitracin solution through metal bath at the temperature of 40 to 60 DEG C for 1 to 2 hours, and ultrasonically processing for 30 seconds; feeding a gold perchloride solution into the bacitracin solution, and then transferring into a double-layer gas bath oscillator to incubate for 20 to 30 hours at the speed of 100 to 150 rpm and under the temperature of 20 to 25 DEG C; feeding 60 to 90 microlitre sodium borohydride as a reducing agent into the incubated solution, and controlling the reaction temperature to be 21 to 23 DEG C to react for 40 to 60 minutes, thus obtaining the spherical gold nanoparticles of which the particle is 80 to 90nm. The method has the advantages that the process is simple, the shape and the appearance can be controlled, and the reaction conditions are green and mild; the prepared spherical gold nanoparticles are high in specific surface area, high in dispersibility, and high in metal load rate; the phenomenon of agglomerating of the gold nanoparticles in a traditional preparation process can be overcome.

Description

technical field [0001] The invention belongs to the technical field of materials, in particular to a method for preparing metal materials. Background technique [0002] Noble metal nanoparticles have unique surface effects, quantum effects, small size effects and macroscopic quantum tunneling effects, and thus derive many special properties that conventional materials do not have, such as: magnetism, light, sound, heat, and electricity of noble metal nanoparticles. and other superior characteristics. [0003] As a representative of noble metal nanoparticles, gold nanoparticles have some special properties in addition to the excellent properties of nanoparticles, such as: good stability, antibacterial, antibacterial function, fluorescence effect, single electron transition, surface plasmon resonance Wait. Since gold nanoparticles are inert metals, they are not sensitive to air and light, and will not be corroded by water and oxygen, making them more widely used in various f...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/065B22F1/054
Inventor 高大威王梓高发明边可新李彦集薛伟利尹甜
Owner YANSHAN UNIV
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