Method for promoting nanoparticles to enter cells efficiently based on nanosecond pulsed electric field

A nanoparticle and pulsed electric field technology, applied in the field of biology, can solve the problems of limiting clinical application and lack of uniform use standards
CN105903014AInactive Publication Date: 2016-08-31PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2016-08-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for promoting nanoparticles to enter cells. The method for promoting the nanoparticles to enter the cells has the advantages that the cells are subjected to pretreatment by the nanosecond pulsed electric field to promote the number of the nanoparticles entering the cells to be increased remarkably and are heated uniformly and effectively under the action of an alternating magnetic field, the pure nanosecond pulsed electric field has little effect on activity of the cells, and accordingly the method verifies that the nanosecond pulsed electric field is capable of promoting the nanoparticles to enter the cells effectively as a safe physical pretreatment means and is of potential clinical application value on cell imaging and treatment.
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Description

technical field

[0001] The invention belongs to the field of biology and relates to a method for efficiently promoting the entry of nanoparticles into cells by using a nanosecond pulsed electric field. Background technique

[0002] Nanoscale materials are materials ranging from 1-100nm in at least one dimension. Compared with bulk materials, nanomaterials have unique optical, electrical, mechanical and chemical properties, and can be effectively used in imaging and other fields.

[0003] Nanomaterials have a high specific surface area due to their small particle size, and are widely used in the research of dyes, drugs or gene carriers, for the diagnosis and treatment of diseases, and for drug delivery, such as magnetic nanoparticles loaded with anti-tumor drugs, entering cells Afterwards, the treatment of tumors can be realized, and at the same time, magnetic nanoparticles can be used as magnetic resonance contrast agents for magnetic resonance imaging to monitor the therape...

Claims

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