Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Acyclovir medicine composition and medical purpose thereof

A composition and drug technology, applied in the field of pharmaceutical compositions of acyclovir, can solve problems such as no reports related to pancreatic cancer, and achieve the effects of outstanding substantive characteristics, significant progress, and improved therapeutic effect.

Inactive Publication Date: 2016-08-31
SUZHOU BINUOJIA PHARMA CO LTD
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there has been no report on the correlation between the pharmaceutical composition of acyclovir and pancreatic cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Acyclovir medicine composition and medical purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0022] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0023] Separation method: (a) Crush the dried root (5kg) of Clematis clematis, extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and then use petroleum ether ( 4L×3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b ) The ethyl acetate extract in step (a) was removed with D101 macroporous resin, first eluted with 8% ethanol for 10 column volumes, then with 70% ethanol for 12 column volumes, and collected 70% eluat...

Embodiment 2

[0026] Example 2: Inhibitory effect on pancreatic cancer cells

[0027] 1. Materials and Instruments

[0028] Human pancreatic cancer MiaPaCa-2 cells were kindly donated by the Cancer Research Institute of the Cancer Hospital Affiliated to Tianjin Medical University. Compound (I) is self-made, and the preparation method is shown in Example 1. FBS and trypsin-EDTA digestion solution were purchased from Hyclone Company in the United States. PBS powder was purchased from Tianjin Runtai Technology Development Co., Ltd. DMEM low-sugar medium was purchased from Gibco, USA. MTT was purchased from Sigma, USA. DMSO was purchased from Beijing Chemical Plant. Penicillin Sodium for Injection was purchased from Harbin Pharmaceutical Group General Pharmaceutical Factory. Streptomycin sulfate for injection was purchased from Dalian Merro Pharmaceutical Factory.

[0029] Ultra-clean bench, cell incubator (Thermo Company, USA), 4°C refrigerator, -20°C refrigerator (Shandong Qingdao Haie...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an acyclovir medicine composition and a medical purpose thereof. The acyclovir medicine composition comprises acyclovir and a natural product compound (I) with novel structure, wherein the natural product compound (I) is separated from dried clematis root. When the acyclovir and the natural product compound (I) singly act, the effect of treating pancreatic cancer is weaker; when the acyclovir and the natural product compound (I) jointly act, the effect of treating pancreatic cancer is obviously improved, and the medicine for treating the pancreatic cancer can be developed. Compared with the prior art, the acyclovir medicine has significant substantive features and obvious progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the treatment of pancreatic cancer, in particular to a pharmaceutical composition of acyclovir and its medical application for treating pancreatic cancer. Background technique [0002] Acyclovir is a synthetic purine nucleoside analogue. It is mainly used for various infections caused by herpes simplex virus, and can be used for initial or recurrent skin, mucous membrane, external genital infection and HSV infection in immunocompromised persons. It is the drug of choice for the treatment of HSV encephalitis, and it is superior to adenosine vidarabine in reducing morbidity and mortality. It can also be used for herpes zoster, Epstein-Barr virus, and immunodeficiency complicated by chickenpox and other infections. For topical use on the skin only, acyclovir has less skin absorption. [0003] Aciclovir is an antiviral medicine. In vitro, it has inhibitory effect on herpes simplex virus, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C49/743C07C45/78C07C45/79C07C45/80A61K31/122A61K31/522A61P35/00A61P1/18
CPCA61K31/122A61K31/522C07C45/78C07C45/79C07C45/80C07C49/743A61K2300/00
Inventor 徐珍
Owner SUZHOU BINUOJIA PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com