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Method for realizing local interventional therapy on osteosarcoma by adopting degradable multi-drug-loading controlled-release internal implant

A technology for interventional therapy and osteosarcoma, which is applied in the clinical treatment of orthopedic surgery, the development of new drugs, and the research of special drugs. Optimization of therapeutic effect, precise control of release concentration and speed

Inactive Publication Date: 2016-09-21
刘萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional drug-loaded implants can only carry one drug, and the drug release rate and concentration cannot be controlled, requiring a second operation, and cannot be individualized treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Step 1: Preparation of individualized degradable multi-drug-loaded controlled-release implants; through the CAD design of the three-dimensional structure of the drug-loaded implants, use mimics and autoCAD software to design spheres or cylinders according to human anatomical characteristics and three-dimensional geometry principles Or fan-shaped or sheet-shaped implants with different geometric shapes, and compared and tested by computer, and designed different combinations of single-loaded and multi-drug-loaded implants such as methotrexate, cisplatin, doxorubicin, and ifosfamide The drug distribution method and manufacturing process;

[0015] Step 2: Rapid prototyping raw material composition preparation and process parameter setting; (1) PLLA preparation: PLLA particles are prepared by grinding, and after screening, the effects of PLLA particles with different diameters on the internal structure density and porosity of the internal plant are studied; (2) Bonding Agen...

Embodiment 2

[0017] Step 1: Preparation of individualized degradable multi-drug-loaded controlled-release implants; through the CAD design of the three-dimensional structure of the drug-loaded implants, use mimics and autoCAD software to design spheres or cylinders according to human anatomical characteristics and three-dimensional geometry principles Or fan-shaped or sheet-shaped implants with different geometric shapes, and compared and tested by computer, and designed different combinations of single-loaded and multi-drug-loaded implants such as methotrexate, cisplatin, doxorubicin, and ifosfamide The drug distribution method and manufacturing process;

[0018] Step 2: Rapid prototyping raw material composition preparation and process parameter setting; (1) PLLA preparation: PLLA particles are prepared by grinding, and after screening, the effects of PLLA particles with different diameters on the internal structure density and porosity of the internal plant are studied; (2) Bonding Agen...

Embodiment 3

[0020] Step 1: Preparation of individualized degradable multi-drug-loaded controlled-release implants; through the CAD design of the three-dimensional structure of the drug-loaded implants, use mimics and autoCAD software to design spheres or cylinders according to human anatomical characteristics and three-dimensional geometry principles Or fan-shaped or sheet-shaped implants with different geometric shapes, and compared and tested by computer, and designed different combinations of single-loaded and multi-drug-loaded implants such as methotrexate, cisplatin, doxorubicin, and ifosfamide The drug distribution method and manufacturing process;

[0021] Step 2: Rapid prototyping raw material composition preparation and process parameter setting; (1) PLLA preparation: PLLA particles are prepared by grinding, and after screening, the effects of PLLA particles with different diameters on the internal structure density and porosity of the internal plant are studied; (2) Bonding Agen...

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PUM

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Abstract

The invention belongs to the technical fields of clinical treatment of bone surgery, novel drug development and special drug research, and discloses a method for realizing local interventional therapy on osteosarcoma by adopting a degradable multi-drug-loading controlled-release internal implant. The method comprises the following steps: step 1, preparing the individual degradable multi-drug-loading controlled-release internal implant; and step 2, preparing components of a rapidly-forming raw material and setting technological parameters. In the method provided by the invention, the individual customization is realized, the secondary operation is not needed, the multi-drug-loading is realized, the release is controllable, the accurate entity manufacturing is realized, the diversified materials are adopted, the assembly is not needed, the preparation time is short, the space required by the preparation is small, the portability is high, the amount of abandoned by-products is extremely small, the design space is not limited, the manufacturing technological barrier does not exist, the manufacturing cost has no direct relevance to the design complexity, and the manufacturing cost has no direct relevance to the manufacturing diversity, therefore, the treatment effect is optimized, the side effects of the drugs are minimized, and meanwhile, the occurrence of the drug tolerance and the drug abuse is avoided.

Description

technical field [0001] The invention specifically relates to a method for local interventional treatment of osteosarcoma with degradable multi-drug-loaded controlled-release implants, and belongs to the technical fields of clinical treatment of orthopedic surgery, development of new drugs, and research of special drugs. Background technique [0002] Osteosarcoma is a highly malignant primary intramedullary tumor. It is the most common malignant bone tumor, accounting for about 40% of primary malignant bone tumors in the whole body. It has a very poor prognosis and a high mortality and disability rate. Osteosarcoma commonly occurs in adolescents aged 10-20, and the most common sites are the distal femur, proximal tibia, and proximal humerus, especially the metaphysis (91%) and diaphysis (9%). In recent years, the incidence of osteosarcoma has been soaring, as high as (4-5) / 106, and more than 5,000 new osteosarcoma patients are diagnosed every year, which has brought great pai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K9/00A61P35/00
CPCA61K9/0024A61K47/34
Inventor 刘萍王永会周东生孙亮张鹏贺宇
Owner 刘萍