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Coupling lubricating solution for B ultrasonic examination

A technology of lubricating liquid and mixed liquid is applied in the field of couplant, which can solve the problems of serious bacterial infection rate of ultrasonic probe, iatrogenic cross-infection, damage to the function of couplant, etc., and achieves the effect of stable physical and chemical index performance, low cost, and reduced dosage.

Inactive Publication Date: 2016-09-21
孙百梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ultrasound probes used in hospitals are generally not disinfected. After the inspection, only white tissue paper is used to wipe it, and then the next inspection is performed, and medical ultrasound probes are frequently in contact with healthy checkups, patients with infectious diseases, patients with skin diseases, infants, and pregnant women. For different groups of people, the probes often carry a variety of pathogenic microorganisms in clinical examinations, and there is a potential risk of iatrogenic cross-infection, resulting in a serious bacteria-carrying rate of ultrasonic probes.
At present, there are disinfectant and sterilizing ultrasonic couplants on the market, but these couplants have many problems such as poor bactericide effect, unreasonable compatibility of components, easy corrosion of instruments, damage to the function of the couplant itself, and irritation of the skin.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A coupling lubricating fluid for B-ultrasound examination, which is prepared according to the following process: step 1) mixing, stirring and heating, step 2) stirring evenly, step 3) heating and stirring, step 4) ethanol extraction, step 5) stirring , packaging and sealing;

[0019] Specifically, the coupling lubricant is prepared according to the following process:

[0020] Step 1) Mixing, stirring and heating: Mix propylene glycol, glycerin and hyaluronic acid in a mass ratio of 25:10:2, stir at 300 rpm for 10 minutes to obtain a mixed solution; add hydroxyethyl cellulose to the above mixed solution , stirred at 500 rpm for 3 minutes, then heated to 60°C, kept warm for 30 minutes, cooled to room temperature, and obtained component A; wherein, the mass ratio of hydroxyethyl cellulose and the mixed solution was 1:55;

[0021] Step 2) Stir evenly: add sodium lauryl sulfate and vitamin E to deionized water in turn, and stir evenly to obtain component B; wherein, the mas...

Embodiment 2

[0026] A coupling lubricating fluid for B-ultrasound examination, which is prepared according to the following process: step 1) mixing, stirring and heating, step 2) stirring evenly, step 3) heating and stirring, step 4) ethanol extraction, step 5) stirring , packaging and sealing;

[0027] Specifically, the coupling lubricant is prepared according to the following process:

[0028] Step 1) Mixing, stirring and heating: Mix propylene glycol, glycerin and hyaluronic acid in a mass ratio of 25:10:2, stir at 300 rpm for 10 minutes to obtain a mixed solution; add hydroxyethyl cellulose to the above mixed solution , stirred at 500 rpm for 3 minutes, then heated to 60°C, kept warm for 30 minutes, and cooled to room temperature to obtain component A; wherein, the mass ratio of hydroxyethyl cellulose to the mixed solution was 2:95;

[0029] Step 2) Stir evenly: add sodium lauryl sulfate and vitamin E to deionized water in turn, and stir evenly to obtain component B; wherein, the mass...

Embodiment 3

[0034] Performance Testing:

[0035] Taking the coupling lubricating fluid prepared in Example 1 as an example, it was tested: the appearance is colorless and transparent gel-like, without bubbles and insoluble foreign matter, the pH value is 7.0, the viscosity is 23.1Pa.s, the sound velocity is 1559m / s, and the sound velocity is 1559m / s. The characteristic impedance is 1.56×10 6 Pa.s / m, sound attenuation is 0.027Db / (cm.MHz), non-cytotoxic, non-skin sensitizing, stored at 37°C for half a year, no crystallization, turbidity, precipitation in appearance, in line with relevant standards.

[0036] The antibacterial test is as follows:

[0037] Experimental strains: Staphylococcus aureus, Escherichia coli, Shigella, pneumococcus.

[0038] Experimental procedure: Inoculate the four strains into the nutrient broth medium, culture at 30°C for 24 hours, isolate the bacterial liquid, and dilute it to 1×10 8 Each / ml, then four kinds of bacterial solutions are mixed to obtain mixed ba...

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Abstract

The invention belongs to the technical field of coupling agents and discloses a coupling lubricating solution for B ultrasonic examination. The coupling lubricating solution is prepared according to the following process: step (1), mixing, stirring and heating; step (2), uniformly stirring; step (3), heating and stirring; step (4), extracting with ethanol; and step (5), stirring, sub-packaging and sealing. The coupling lubricating solution has stable physicochemical index performances and has disinfection and sterilization effects.

Description

technical field [0001] The invention belongs to the technical field of couplants, and in particular relates to a coupling lubricating fluid for B-ultrasonic inspection. Background technique [0002] B-ultrasound is a routine diagnostic method in hospitals. B-ultrasound can clearly display various cross-sectional images of various organs and surrounding organs. Because the images are full of solidity and close to the real structure of anatomy, the application of ultrasound can make an early diagnosis. There are various grades of ultrasonic diagnostic instruments, and the advanced high-end instruments are complex in structure and have the characteristics of high performance, multi-function, high resolution and high definition. Their basic components include five components: emission, scanning, reception, signal processing and display, which are divided into two major components, namely the host and the probe. A host can have one, two or more probes, and one or dozens or ev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K36/67A61P31/02
CPCA61K36/355A61K36/67A61K49/22A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 孙百梅刘敏
Owner 孙百梅
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