S-(5-substituted-1, 3, 4-thiadiazole)-(5-substituted phenyl)-2-furancarbothioic acid ester compound, preparation method and application thereof
A technology for furanthiocarboxylic acid and ester compounds, which is applied in the field of synthesis of heterocyclic compounds, and achieves the effects of high yield, expanded application prospects, and novel structures
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[0053] Example 1: S-1,3,4-thiadiazole-5-(4-chlorophenyl)-2-furan thiocarbamate (I-1-1) and S-(5-methyl- Preparation of 1,3,4-thiadiazole)-5-(4-chlorophenyl)-2-furan thiocarbamate (I-1-2)
[0054]
[0055] Add 15mmol 1,3,4-thiadiazole-2-thiol (or 5-methyl-1,3,4-thiadiazole-2-thiol) and 10ml di Chloromethane, add 10% (wt.) sodium hydroxide aqueous solution containing 15 mmol sodium hydroxide at room temperature, control the rate of addition, and keep the temperature at room temperature. After this was completed, a dichloromethane solution containing 7.5 mmol of 5-(4-chlorophenyl)-2-furoyl chloride was added dropwise. Control the rate of addition so that both are added at the same time. After the dropwise addition, slowly raise the temperature to 50°C, and react at 50°C for 3-10 hours. After the reaction was completed, filter to remove the precipitate, and rotate the filtrate to remove the solvent to obtain a light yellow solid. Use a silica gel column (eluent: V petroleum...
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