Cross-linking agent of phenylboronic acid group, preparation method and multiple sensitive hydrogel preparation method

Abstract

The invention provides a cross-linking agent of a phenylboronic acid group, a preparation method and a multiple sensitive hydrogel preparation method. 3-carboxyphenylboronic acid and cystamine or hydrochloride of cystamine are used as raw materials, amidation is carried out for 2-24 h in water or a phosphate buffered solution at the temperature of 5-60 DEG C in the presence of a catalyst, and filtering, washing and drying are carried out, so that the cross-linking agent is obtained. The cross-linking agent is dissolved in dimethyl sulfoxide, tetrahydrofuran or N,N'-dimethyl formamide organic solvent, then added into a polymer water solution containing a catechol group, the polymer containing the catechol group is subjected to a cross-linking reaction through forming of the boric acid ester bond, and multiple sensitive hydrogel is formed. The raw materials adopted for cross-linking agent preparation are commercial products easy to obtain. According to the preparation process, reaction conditions are mild, the process is simple, and the product is easy to separate and purify. The polymer is wide in selection range and has the high application value in the biomedical field.

Description

technical field [0001] The invention relates to the preparation and application of a novel cross-linking agent based on phenylboronic acid groups to construct a polymer hydrogel with multiple sensitivity to glucose, pH and redox stimulation, which belongs to the polymer functional gel technology field. Background technique [0002] Polymer gel is a three-dimensional network structure formed by water-soluble or hydrophilic polymers through chemical cross-linking (covalent bond, ionic bond) or physical cross-linking (hydrogen bond, van der Waals force, physical entanglement). It swells in water and retains a large amount of water without dissolving, which is very similar to the tissue environment of organisms, and has good biocompatibility and bioadhesion. Especially the environment-sensitive polymer gel, its dispersion state or phase state can change with the external environment such as temperature, pH value, ionic strength, light, electricity, magnetic field or chemical su...

AI Technical Summary

Problems solved by technology

However, at present, various crosslinking agents based on phenylboronic acid groups are mainly used to prepare single or dual sensitive hydrogels, and there are no research reports on the preparation of multiple sensitive hydrogels.

In addition, the preparation process of various crosslinking agents based on phenylboronic acid groups is relatively complicated, the raw materials are relatively expensive, and the purification and separation of products are difficult, which limits their research and application.

Images