Photocureable double-layer polysiloxane supra-molecular elastomer dressing for chronic skin wounds and preparation method of dressing

A supramolecular elastomer, polysiloxane technology, applied in pharmaceutical formulations, medical science, bandages, etc., can solve problems such as increasing nursing workload, aggravating patient pain, etc., to accelerate wound healing, resist bacterial infection, and promote growth. and regeneration effect

Active Publication Date: 2016-10-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the clinical nursing practice of chronic refractory skin wounds in my country, gauze dressings and foam dressings are still the main ones at present. The former is difficult to provide a good moist healing environment for t...

Method used

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  • Photocureable double-layer polysiloxane supra-molecular elastomer dressing for chronic skin wounds and preparation method of dressing
  • Photocureable double-layer polysiloxane supra-molecular elastomer dressing for chronic skin wounds and preparation method of dressing
  • Photocureable double-layer polysiloxane supra-molecular elastomer dressing for chronic skin wounds and preparation method of dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: a kind of skin wound dressing (BLF) with double-layer structure based on polysiloxane supramolecular elastomer 46 ) preparation:

[0057] (1) Synthesis of terminal hydrogen polysiloxane (PHMS): at room temperature, in a reaction kettle equipped with mechanical stirring, 1,1,3,3-tetramethyldisiloxane (300g) and octamethyl Cyclotetrasiloxane molar ratio HMM: D 4 = 1:15 feed, then add the equivalent of D 4 Sulfuric acid with a mass of 2% and a concentration of 80wt%. After stirring the reaction at room temperature for 20 h, separate the lower sulfuric acid phase with a separatory funnel, and use excess NaHCO 3 The residual sulfuric acid in the product was neutralized, and the crude product obtained after vacuum filtration was distilled under reduced pressure at 160° C. for 3 h to obtain the purified PHMS.

[0058] (2) Ester-terminated polysiloxane (PDMS-tBMA 2 ) synthesis: in the reaction kettle equipped with reflux condenser, nitrogen protection device ...

Embodiment 2

[0064] Embodiment 2: a kind of skin wound dressing (BLF) with double-layer structure based on polysiloxane supramolecular elastomer 30 ) preparation

[0065] (1) Synthesis of terminal hydrogen polysiloxane (PHMS): at room temperature, in a reaction kettle equipped with mechanical stirring, 1,1,3,3-tetramethyldisiloxane (300g) and octamethyl Cyclotetrasiloxane molar ratio HMM:D 4 = 1:10 feed, then add the equivalent of D 4 Sulfuric acid with a mass of 3% and a concentration of 86wt%. After stirring the reaction at room temperature for 20 h, separate the lower sulfuric acid phase with a separatory funnel, and use excess NaHCO 3 The residual sulfuric acid in the product was neutralized, and the crude product obtained after vacuum filtration was distilled under reduced pressure at 160° C. for 3 h to obtain the purified PHMS.

[0066] (2) Ester-terminated polysiloxane (PDMS-tBMA 2 ) synthesis: in the reaction kettle equipped with reflux condenser, nitrogen protection device an...

Embodiment 3

[0072] Embodiment 3: a kind of skin wound dressing (BLF) with double-layer structure based on polysiloxane supramolecular elastomer 16 ) preparation

[0073] (1) Synthesis of terminal hydrogen polysiloxane (PHMS): at room temperature, in a reaction kettle equipped with mechanical stirring, 1,1,3,3-tetramethyldisiloxane (300g) and octamethyl Cyclotetrasiloxane molar ratio HMM:D 4= 1:5 feed, then add the equivalent of D 4 Mass 4% concentration is 90wt% sulfuric acid. After stirring the reaction at room temperature for 20 h, separate the lower sulfuric acid phase with a separatory funnel, and use excess NaHCO 3 The residual sulfuric acid in the product was neutralized, and the crude product obtained after vacuum filtration was distilled under reduced pressure at 160° C. for 3 h to obtain the purified PHMS.

[0074] (2) Ester-terminated polysiloxane (PDMS-tBMA 2 ) synthesis: in the reaction kettle equipped with reflux condenser, nitrogen protection device and constant pressur...

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Abstract

The invention discloses a photocureable double-layer polysiloxane supra-molecular elastomer dressing for chronic skin wounds and a preparation method of the dressing. The method comprises the following steps: making carboxyl-terminated polysiloxane sequentially react with mono-functionality and dual-functionality primary amino compounds, so that a siloxane oligomer containing a secondary amine group is obtained; reacting the siloxane oligomer with hexyl diisocyanate and cinnamoyl chloride, so that a polysiloxane supra-molecular elastomer and a photocureable prepolymer are obtained; and coating the photocureable prepolymer on the polysiloxane supra-molecular elastomer and curing the prepolymer under ultraviolet irradiation to obtain a polysiloxane supra-molecular elastomer is obtained; therefore, the polysiloxane supra-molecular elastomer dressing is prepared. The dressing is good in air permeability and hydroscopicity; a substrate of the dressing is relatively good in elasticity and low in viscosity while a binding layer of the dressing is good in viscosity; the dressing, when used as a chronic wound dressing, is conducive to the growth and the regeneration of wound surface tissues and is capable of accelerating healing of wounds. The dressing, which is prepared from the polysiloxane, is free from cytotoxicity and skin irritation and is good in good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of synthetic polymer biomaterials, in particular to a photocurable double-layer polysiloxane supramolecular elastomer dressing for chronic skin wounds and a preparation method thereof. Background technique [0002] Chronic skin wounds, such as skin ulcers, pressure sores, diabetic foot, etc., have always been one of the clinical problems because they are common in the elderly or diabetic patients with poor physiological functions. In 1962, Winter published the "Moist Wound Healing Theory" in Nature, which gave people a breakthrough understanding of the wound healing process. Studies have found that various cells, enzymes, and growth factors on the wound are less active under dry conditions, but greatly increase their biological activity in a humid environment, which can promote the growth of granulation tissue and help wound healing. What's more, a warm, moist healing environment didn't increase the chance ...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/42C08G83/00
CPCA61L15/26A61L15/42A61L2400/16C08G83/008C08L87/00
Inventor 张安强犹阳黄炜妍林雅铃
Owner SOUTH CHINA UNIV OF TECH
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