Inorganic and organic hybrid material as well as preparation method and application thereof
An organic hybrid and inorganic technology, applied in the field of nanomaterials, which can solve the problems of low efficiency and small drug adsorption capacity
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[0041] The present invention also provides a method for preparing an inorganic-organic hybrid material, the method comprising:
[0042] Step 1: Mix water, ammonia water and isopropanol to obtain a mixed solution, add the mixed solution of ethyl orthosilicate and isopropanol to the above mixed solution, and then add ethyl orthosilicate to react to obtain solid SiO 2 ;
[0043] Step 2: Combine polyvinylpyrrolidone and the solid SiO obtained in step 1 2 reaction, adding alkali solution, and then calcining at 550-600°C for 3.5-4h to obtain porous SiO 2 ;
[0044] Step three: the porous SiO obtained in step two 2 React with 3-aminopropyl-triethoxysilane to give SiO 2 -NH 2 ;
[0045] Step 4: Mix L-glutamic acid and dichloroethanol in concentrated H 2 SO 4 The mixture was poured into an ice solution of sodium bicarbonate overnight to obtain L-chloroethanol glutamate (CELG), and CELG and tetrahydrofuran were reacted under triphosgene and nitrogen conditions to obtain γ-2-chlo...
Embodiment 1
[0056] Add 55.7mL of primary water, 30.8mL of ammonia water and 33mL of isopropanol into the reaction flask and stir at room temperature, then add 1.4mL of tetraethyl silicate (TEOS) and 118mL of isopropanol mixed solution into the stirring reaction flask , and then stirred for 20 minutes after white turbidity appeared, then added 12.6 mL of tetraethyl orthosilicate dropwise for 1-2 seconds into the stirring reaction flask, stirred for 4 hours after the addition, and then centrifuged the obtained solution. After that, it was treated with water and ethanol, and dried in vacuum to obtain solid SiO 2 ;
[0057] Dissolve 1g of solid SiO2 and 5g of PVP in 100mL of deionized water, react at 100°C for 3h, add 25mL of 0.1g / mL NaOH solution after cooling, centrifuge after reacting for 1h, vacuum dry and place in a muffle furnace at 600°C Porous SiO was obtained after calcination for 4 h 2 ;
[0058] figure 1 Porous SiO prepared for Example 1 of the present invention 2 N 2 Adsorpt...
Embodiment 2
[0068] Add 55.7mL of primary water, 30.8mL of ammonia water and 33mL of isopropanol into the reaction flask and stir at room temperature, then add 1.4mL of tetraethyl silicate (TEOS) and 118mL of isopropanol mixed solution into the stirring reaction flask , and then stir for 20 minutes after white turbidity appears, then add 12.6 mL of tetraethyl orthosilicate dropwise for 1-2 seconds into the stirring reaction bottle, stir for 3.5 hours after the addition, and centrifuge the obtained solution , then treated with water and ethanol, and dried in vacuum to obtain solid SiO 2 ;
[0069] 1g solid SiO 2 Dissolve 5g PVP in 100mL deionized water, react at 100°C for 2.5h, add 25mL of 0.1g / mL NaOH solution after cooling, centrifuge after 1h, vacuum dry and calcinate in a muffle furnace at 550°C for 3.5h Porous SiO 2 ;
[0070] Porous SiO 2 Disperse in deionized water and stir at high speed, then add 3-aminopropyl-triethoxysilane (APTES) dropwise into the reaction system, adjust th...
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