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Ethyl cellulose drug-loading nanofiber membrane and preparation method and application thereof

A technology of ethyl cellulose and nanofiber membranes, which is applied in the fields of medical formula, fiber chemical characteristics, drug delivery, etc., can solve the problems of side effects, ulcers, bleeding, gastrointestinal irritation, etc., and achieve easy operation and prolonged administration time , the effect of mild experimental conditions

Inactive Publication Date: 2016-10-26
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ketoprofen has side effects on the digestive tract, and long-term use can greatly stimulate the stomach and intestines, and can cause adverse reactions such as ulcers and bleeding.

Method used

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  • Ethyl cellulose drug-loading nanofiber membrane and preparation method and application thereof
  • Ethyl cellulose drug-loading nanofiber membrane and preparation method and application thereof
  • Ethyl cellulose drug-loading nanofiber membrane and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Weigh 0.402 g of EC solid powder with a balance and dissolve it in 2 mL of hexafluoroisopropanol.

[0035] (2) Add 0.04 g of the ketoprofen drug to the above solution and make it completely dissolved, and stir for 48 hours with a magnetic stirrer until the two are completely dissolved in the solvent and mixed uniformly.

[0036] (3) Put 5mL of the prepared spinning solution into the electrospinning device, adjust the spinning parameters for electrospinning, the spray flow rate is 0.3mL / h, the static voltage is 13kV, the receiving distance is 15cm, and the ambient temperature The temperature is 25°C, the humidity is 40-50%, and the spinning time is 5 hours; the collected fiber membranes are placed in a vacuum drying box and dried at room temperature for 24 hours to obtain ethyl cellulose drug-loaded nanofiber membranes.

[0037] (4) Collect a few nanofibers with a copper mesh during the spinning process, dry the collected nanofibers at room temperature for 24 hours, and the...

Embodiment 2

[0039] (1) Weigh 0.601 g of EC solid powder with a balance and dissolve it in 3 mL of hexafluoroisopropanol.

[0040] (2) Add 0.06 g of the ketoprofen drug to the above solution and make it completely dissolved, and stir for 48 hours with a magnetic stirrer until the two are completely dissolved in the solvent and mixed uniformly.

[0041] (3) Put 3mL of the configured spinning solution into the electrospinning device, adjust the spinning parameters for electrospinning, the spray flow rate is 0.2mL / h, the static voltage is 12kV, the receiving distance is 17cm, and the ambient temperature The temperature is 25°C, the humidity is 40-50%, and the spinning time is 6h.

[0042] (4) Put the collected nanomembrane into a vacuum drying box and dry at room temperature for 24 hours to obtain an ethylcellulose drug-loaded nanofiber membrane.

[0043] (5) SEM characterization of ethyl cellulose drug-loaded nanofiber membrane Figure 2A As shown, the fibers are uniformly distributed in a network s...

Embodiment 3

[0045] (1) Weigh 0.799 g of EC solid powder with a balance, and dissolve it in 4 mL of hexafluoroisopropanol.

[0046] (2) Add 0.08 g of the ketoprofen drug to the above solution and make it completely dissolved, and stir for 48 hours with a magnetic stirrer until the two are completely dissolved in the solvent and mixed uniformly.

[0047] (3) Put 4mL of the configured spinning solution into the electrospinning device, adjust the spinning parameters for electrospinning, the spray flow rate is 0.4mL / h, the static voltage is 13kV, the receiving distance is 16cm, and the ambient temperature The temperature is 25°C, the humidity is 40-50%, and the spinning time is 7h.

[0048] (4) Put the collected nanomembrane into a vacuum drying oven at 25° C. and dry for 24 hours to obtain an ethylcellulose drug-loaded nanofiber membrane.

[0049] (5) Cut out the 1×1cm fiber membrane and conduct Fourier transform infrared spectroscopy test.

[0050] (6) The FTIR spectra of ketoprofen, ethylcellulose n...

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Abstract

The invention relates to an ethyl cellulose drug-loading nanofiber membrane and preparation method and application thereof. The components of the nanofiber membrane include ethyl cellulose and drug of which the mass ratio is 1:10 to 1:20. The preparation method includes the steps of: adding the drug to an ethyl cellulose (EC) solution, and stirring to disperse uniformly, thereby obtaining a spinning solution; and performing electrostatic spinning, and drying an obtained fibrous membrane, thereby obtaining an ethyl cellulose drug-loading nanofiber membrane. The preparation method provided by the invention is simple and feasible; and the prepared nanofiber membrane is a hydrophobic nanometer material having a drug slow-release function and can be used as a biomedical material.

Description

Technical field [0001] The invention belongs to the field of preparation of electrostatic spinning fibers, and particularly relates to an ethyl cellulose drug-loaded nanofiber membrane and a preparation method and application thereof. Background technique [0002] As a new type of material, nanofiber material is the most cutting-edge research field in the field of nanoscience and has been widely used in functional materials. Electrospinning technology is a process in which liquid droplets form a jet stream under the action of a polymer solution or melt under the action of a high-voltage electrostatic field. It is currently one of the most important methods for preparing nanofibers. As a mature, simple, convenient, and low-cost nanofiber preparation technology, electrospinning can prepare nanofibers and nanostructured materials with large specific surface area and high porosity, and the size can be controlled within a dozen nanometers to a few microns. between. Electrospun nanof...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4258D01F1/10A61K9/70A61K47/38
CPCA61K9/0002A61K9/70A61K47/38D01F1/10D04H1/4258D04H1/728
Inventor 朱利民刘凯琳桑青青吕瑶李赫宇
Owner DONGHUA UNIV
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