Method for improving stability and sensitivity in content detection of formaldehyde in cosmetics

A technology for formaldehyde content and cosmetics, which is applied in the field of detection of formaldehyde content in cosmetics, can solve the problems of stability and sensitivity of test results, and achieve the effects of high sensitivity, accurate results and convenient operation

Inactive Publication Date: 2016-10-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be foreseen that any uncertainty in the two measurements (such as: baseline drift caused by factors such as fine suspended particles in the test solution and the stability of the spectrometer) will have a significant impact on the stability and sensitivity of the test results
[0004] For this reason, it is necessary to improve the existing methods to overcome the shortcomings of spectrophotometry in the determination of low-level formaldehyde in colored samples.

Method used

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  • Method for improving stability and sensitivity in content detection of formaldehyde in cosmetics
  • Method for improving stability and sensitivity in content detection of formaldehyde in cosmetics
  • Method for improving stability and sensitivity in content detection of formaldehyde in cosmetics

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Effect test

Embodiment 1

[0035] 1. Pretreatment

[0036] Accurately weigh 2.5 g of the sample and place it in a 50 mL stoppered colorimetric tube. Add 25 mL of sodium sulfate solution, shake, add water to the mark, and place in a water bath at 40°C for 1 hour at constant temperature. The sample solution was rapidly cooled, transferred to a centrifuge tube, and centrifuged at 3000 rpm. Filter with a glass funnel, and the filtrate is used as the solution to be tested.

[0037] 2. Sample preparation

[0038] Take 5mL of the solution to be tested in a 10mL stoppered colorimetric tube. Add 5.00 mL of ammonium acetate solution of acetylacetone, shake well, heat in a water bath at 40°C for 30 min, and place at room temperature for 30 min to cool. At the same time, in order to reduce the influence of the solution itself or the turbidity of the solution after adding the color developer, take another 5.00mL of the solution to be tested, add 5.00mL of ammonium acetate buffer solution, shake well, and cool it...

Embodiment 2

[0043] Full Spectrum of Standard Formaldehyde Solution and Establishment of Standard Curve

[0044] figure 1It is the absorption spectrum after the color development of the formaldehyde standard solution with different concentrations and the acetylacetone color developer. As shown in the figure, the displayed spectrum of the standard solution has a maximum absorbance at 414nm, and the concentration of formaldehyde in the solution is directly proportional to the corresponding absorbance, which conforms to the Lambert-Beer law. Therefore, when there is no substance with absorbance other than formaldehyde in the measured solution at 414nm, the content of formaldehyde in the solution can be quantitatively detected according to the absorbance at 414nm and the calibration curve.

Embodiment 3

[0046] The influence of baseline drift on detection results

[0047] When analyzing actual samples, it can be observed that even after centrifugation, the solution to be tested and the solution after color development will appear slightly turbid. In order to reduce the interference of the turbidity on the absorbance detection, the ammonium acetate buffer solution without acetylacetone was used as the calibration solution during the experiment. The absorbance of the solution before and after color development is measured separately, and the absorbance of the two measurements is subtracted from the absorbance of the calibration solution. The difference between the obtained values ​​is the net absorbance value of formaldehyde color development. Obviously, in the three tests, the spectral baseline drift caused by the scattering of fine particles in the solution or the stability of the instrument itself is different, which affects the reliability and accuracy of formaldehyde detect...

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Abstract

The invention discloses a method for improving stability and sensitivity in content detection of formaldehyde in cosmetics. The method includes: adding a cosmetic sample into a cuvette with a plug, adding sodium sulfate solution and water, and obtaining a to-be-detected solution through water bath, cooling, centrifuging and filtering; measuring light absorbing degree of all of the to-be-detected solution in a by using a cuvette of 10 mm; drawing an absorbing spectrum figure of formaldehyde standard solutions different in concentration, and obtaining corresponding formaldehyde solution standard curves. When a single-wavelength method is adopted to calculate generated errors, RSD among parallel experiment results can reach 11.46%, but RSD of the method is only 0.485% at most. In addition, the method can effectively correct and eliminate influence of extraction liquid color and base line drift, and the detection limit is 0.75 mg/kg. Therefore the method has the advantages of short analysis time, convenience and quickness in operation, high sensitivity and accurate result and is suitable for detection of formaldehyde in the cosmetics.

Description

technical field [0001] The invention relates to the technical field of formaldehyde detection, in particular to a method for improving the stability and sensitivity of formaldehyde content detection in cosmetics. Background technique [0002] Along with the raising of people's living standard, the use of cosmetics has also accounted for very large proportion in people's daily life. In order to obtain the desired effect, numerous chemical ingredients are often added to cosmetics. However, if these chemical components exceed a certain limit, they will cause harm to the human body. In recent years, among many cosmetic quality and safety issues, excessive formaldehyde content is one of the more serious problems. Although formaldehyde has a good antiseptic effect, if it exceeds a certain limit, it will cause irritation of the skin and mucous membranes, adverse reactions such as skin allergies, nausea, and headaches, and even cause abnormalities in human liver and lung function,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31
CPCG01N21/31
Inventor 闫宁柴欣生
Owner SOUTH CHINA UNIV OF TECH
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