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Medical composite chitosan gel containing medicines promoting wound healing

A technology of chitosan gel and wound healing, which is applied in drug delivery, medical science, and pharmaceutical formulations, etc. It can solve problems such as easy adhesion of new tissues, secondary trauma of wounds, and destruction of growth factors, so as to accelerate wound healing and relieve pain. Pain, the effect of promoting the growth of granulation tissue

Inactive Publication Date: 2016-11-09
SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings used on wounds mainly play an isolation and antibacterial role, but often lead to dryness of the wound, damage to healthy growth factors, and easy adhesion to new tissue, which will lead to secondary trauma of the wound when the dressing is removed

Method used

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  • Medical composite chitosan gel containing medicines promoting wound healing
  • Medical composite chitosan gel containing medicines promoting wound healing
  • Medical composite chitosan gel containing medicines promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Prescription of Medical Composite Chitosan Gel Containing Wound Healing Drugs - Amorphous Gel:

[0057]

[0058]

[0059] The preparation method is:

[0060] (1) carboxymethyl chitosan, hypromellose, povidone K90 and propylene glycol of prescription quantity are dissolved in purified water, and the swelling is uniform; (2) phenytoin sodium of prescription quantity is added to step (1) preparation In the product obtained, stir and mix; (3) use hydrochloric acid / sodium hydroxide to adjust the product prepared in step (2) and adjust the pH value to 7-10, stir evenly and prepare a gel; (4) combine the step (3) The prepared gel is subpackaged and sterilized to obtain the medical composite chitosan gel.

[0061] The prepared amorphous gel is suitable for acute incisions, chronic wounds (various decubitus ulcers, vascular lesion ulcers, osteomyelitis, sinus tracts, etc.), dry wounds and wounds with less exudate, and can provide wound healing environment, and play a rol...

Embodiment 2

[0063] Prescription of medical complex chitosan gel containing wound healing drugs - sheet gel:

[0064]

[0065] Preparation:

[0066] (1) Isobutyl chitosan, carboxymethyl chitosan, sodium carboxymethyl cellulose and glycerin that take the recipe amount are placed in an appropriate amount of purified water, stirred and mixed, and swollen; (2) phenytoin that takes the recipe amount Add sodium to the product prepared in step (1), stir and mix evenly, and let it stand for defoaming; (3) adjust the pH value of the product prepared in step (2) to 6-9 with sodium hydroxide / hydrochloric acid; (4 ) forming the obtained gel on the backing material by salivating, drying to form a film, combining the protective film, cutting, sterilizing, and subpackaging to obtain the medical composite chitosan gel.

[0067] The prepared sheet gel is suitable for acute incisions, chronic wounds (various decubitus ulcers, vascular lesion ulcers, osteomyelitis, sinus tracts, etc.), dry wounds and wou...

Embodiment 3

[0069]Prescription for Medical Complex Chitosan Gel Containing Wound Healing Drugs - Spray Gel:

[0070]

[0071] Preparation:

[0072] (1) Add phenytoin sodium to the sodium hydroxide solution, add propylene glycol and poloxamer to mix and dissolve; (2) add purified water, mix well, add carboxymethyl chitosan, and keep stirring until a gel is formed; ( 3) Use sodium hydroxide / hydrochloric acid to adjust the pH to 8-11, add purified water to the full amount; (4) Sterilize, put it into a sprayer under aseptic conditions, and get ready.

[0073] The prepared spray gel can form a layer of soft protective film after being sprayed on the wound, which plays the role of isolating the wound, protecting the wound surface, providing a moist healing environment for the wound, promoting wound healing and controlling infection.

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Abstract

The invention discloses a medical composite chitosan gel containing medicines promoting wound healing. The medical composite chitosan gel comprises the following compositions in parts by weight: 0.5-10 parts of chitosan high-molecular material, 0.1-8 parts of a medicine promoting wound healing, 0-10 parts of a thickening agent, 1-25 parts of a moisturizing agent, 0-30 parts of a co-solvent / solubilizer, 17-98.4 parts of purified water. The medical composite chitosan gel containing medicines promoting wound healing is capable of effectively keeping the wet environment of a wound, promoting generation of granulation tissue, accelerating wound healing and alleviating wound pain. By employing the chitosan high-molecular material as a matrix and the medicine promoting wound healing as an auxiliary material, the wound dressing combines the advantages that the chitosan high-molecular material is capable of absorbing moisture, keeping moisture, inhibiting bacteria, stopping bleeding and the like and the effect that the medicine promoting wound healing is capable of promoting generation of granulation tissue, accelerating wound healing and alleviating pain, and the gel with excellent performances is prepared.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a medical compound chitosan gel containing wound-healing-promoting medicine. Background technique [0002] The skin and mucous membranes of the human body are the barriers to maintain the stability of the human body environment and prevent the invasion of microorganisms. Damage to the skin and mucous membranes caused by ulcers, trauma, burns and inflammation will cause a series of problems in the body, such as bacterial infection, increased metabolism, Excessive water and protein loss, endocrine and immune system dysfunction, etc., may be life-threatening in severe cases. When the skin and mucous membrane are injured, a suitable dressing should be selected to cover the wound. It can maintain a moist environment for the wound, absorb secretions, relieve pain and control bleeding, thereby promoting rapid wound healing. [0003] The use of dressings is an important means of...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0061A61L26/0066A61L2300/216A61L2300/402A61L2300/412A61L2400/04C08L5/08
Inventor 莫始奎
Owner SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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