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Degradable self-locking cervical vertebra fusion cage and preparation method thereof

A cage, self-locking technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problem of swallowing foreign body sensation in the throat of patients, non-fusion between vertebral bodies, and subsidence of the cage, avoiding complications, strong initial The effect of mechanical stability and cost-saving treatment

Active Publication Date: 2016-11-30
花沐医疗科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that anterior plate fixation accelerates the degeneration of adjacent segments, which can easily lead to the occurrence of adjacent spondylosis, intervertebral disfusion, and cage subsidence, and the implanted plate or loose and slipped screws can cause Foreign body sensation in the patient's throat and difficulty in swallowing. In severe cases, the esophagus may be damaged and an esophageal fistula may occur.

Method used

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  • Degradable self-locking cervical vertebra fusion cage and preparation method thereof
  • Degradable self-locking cervical vertebra fusion cage and preparation method thereof
  • Degradable self-locking cervical vertebra fusion cage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 nanoscale β-tricalcium phosphate

[0048] 1) Prepare micron-sized β-TCP particles that meet the β-TCP standard for surgical implants as raw materials;

[0049] 2) Disperse micron-sized β-TCP particles in a diethylene glycol dispersion, use zirconia beads as the ball milling medium, and continuously ball mill at a speed of 1800r / min for 12 hours;

[0050] 3) Centrifuge to remove diethylene glycol dispersion;

[0051] 4) Rinse with dichloromethane, dry in vacuum, and store.

Embodiment 2

[0052] Embodiment 2 transmission electron microscopy and dynamic light scattering analysis verification

[0053] The particle size of the β-TCP particles prepared in Example 1 was observed by a H-7000 transmission electron microscope, and the acceleration voltage used was 75KV. The particle size of the prepared β-TCP particles was tested by dynamic light scattering. The Zetasizer Nano-ZS potential and particle size analyzer was used to determine the particle size and Zeta potential of polymer drugs. Particle size measurement parameters: He-Ne laser (wavelength 635nm), refractive index and viscosity are n=1.333 and η=0.933cp respectively, measurement temperature is 25°C. Potential measurement parameters: He-Ne laser (wavelength 635nm), scattering angle θ=14°, measurement temperature 25°C.

[0054] Observing the prepared nano-sized β-TCP particles by TEM, the particles are in irregular shape, and the particle size range is 20-160nm (such as figure 1 A, B). Observation by dyn...

Embodiment 3

[0055] The preparation of embodiment 3 polylactic acid / nanometer β-tricalcium phosphate composite material

[0056] 1) Weigh nano-sized β-TCP particles and PLA in proportion according to requirements, wherein the content of β-TCP is 10wt%, 30wt%, 50wt% respectively, prepare a composite solution with dichloromethane, stir and ultrasonically mix to obtain PLA / nano β-TCP complex solution, the solution is poured into a flat-bottomed glass dish, and vacuum-dried to obtain a PLA / nano β-TCP complex film;

[0057] 2) Take the PLA / nano β-TCP composite film, melt and press it at 110°C and 260MPa to form a cylindrical parison of 10×20mm (diameter of the bottom surface×height), and hot press molding (the schematic diagram of hot pressing processing is shown in image 3 As shown, wherein 1 is a composite film, and the rest are processing molds), rapid cooling, and demoulding, the rods of high-strength PLA / nanometer β-TCP composite materials of different proportions can be obtained.

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Abstract

The invention discloses a degradable self-locking cervical vertebra fusion cage and a preparation method thereof. The degradable self-locking cervical vertebra fusion cage is made by the high-strength composite materials made of polylactic acid and beta-tricalcium phosphate, and the biosecurity is high. The application of a self-locking insert can provide stronger initial mechanical stability after the implantation of the fusion cage and promote lumbar interbody fusion, thereby being beneficial to the repair of bone defects, and the self-locking insert can be filled into the bone defect part in the orthopaedic wounding, tumor, infection, and congenital malformation operations.

Description

technical field [0001] The invention belongs to the field of anterior cervical discectomy and intervertebral bone graft fusion, and relates to a degradable self-locking cervical fusion device, in particular to a polylactic acid / nano β-tricalcium phosphate degradable self-locking cervical fusion device and its Preparation. Background technique [0002] Anterior cervical discectomy and bone graft fusion was first reported in the 1950s, and has been widely used in the treatment of various cervical degenerative diseases. It is a classic surgery for cervical spondylosis. Autologous bone has good osteogenic activity, high fusion rate, and no problems such as immune rejection, and is considered the "gold standard" for bone graft fusion. However, the amount of autologous bone is limited, and taking autologous bone may easily lead to pain, hematoma, infection, secondary fracture, etc. in the donor area, and there may be absorption of autologous bone after implantation, collapse of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44A61L27/58A61L27/18A61L27/12
CPCA61F2/4455A61F2002/30004A61F2002/30062A61F2002/30426A61L27/12A61L27/18A61L27/58A61L2430/02C08L67/04
Inventor 董健曹露江立波陈谦李熙雷周晓岗殷潇凡
Owner 花沐医疗科技(上海)有限公司
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