Sustained release preparation used for treating alzheimer's disease, and preparation method thereof

A technology of sustained-release preparations and sustained-release materials, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and pill delivery, etc. smooth and complete effect
CN106166142AInactive Publication Date: 2016-11-30INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Publication Date
2016-11-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a sustained release preparation, and a preparation method thereof. The sustained release preparation contains 0.1 to 0.5% of nitric acid-2-(4-methylthiazole-5-yl) ethyl ester hydrochloride or nitric acid-2-(4-methylthiazole-5-yl) ethyl ester maleate as the main drug; and a main sustained-release material is prepared from hydroxypropyl methyl cellulose, a filling agent, a lubricating agent, and a binding agent or a wetting agent. The nitric acid-2-(4-methylthiazole-5-yl) ethyl ester hydrochloride or nitric acid-2-(4-methylthiazole-5-yl) ethyl ester maleate sustained release preparation is prepared via wet granulation; influences of gastrointestinal peristalsis speed on the release behavior of the sustained release preparation are few; sustained release is realized; relatively stable blood concentration can be maintained; action time is relatively long; less toxic and side effect is caused; and the sustained release preparation is convenient to use. The sustained release preparation is used for preventing and / or treating alzheimer's disease.
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Description

Technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and specifically relates to 2-(4-methylthiazol-5-yl) ethyl nitrate hydrochloride or 2-(4-methylthiazol-5-yl) ethyl nitrate maleic acid Salt sustained-release preparation and preparation method thereof. Background technique

[0002] Known compound 2-(4-methylthiazol-5-yl)ethyl nitrate:

[0003]

[0004] With such as NMDA receptor and gamma-aminobutyric acid type A (GABA A ) Receptors and other amino acid neurotransmitters interact with receptors. The compound is also known to stimulate soluble uridine acyl cyclase (GCase) in the brain. Therefore, this compound is suitable for neuroprotection and realization of cognitive enhancement. See, for example, U.S. Patent No. 6,310,052. It has been found that the new solid form of 2-(4-methylthiazol-5-yl)ethyl nitrate can be prepared as the maleate salt form. See Chinese Patent No. 201180041035.4. The patent describes two formulations of sustained-...

Claims

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