Novel plasma purification system and application thereof
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A purification system and plasma technology, applied in the medical field, can solve the problems of too much fresh plasma, high price, and many complications, and achieve the effects of wide indications, reduction of complication rate, and reduction of the amount of antibodies
Inactive Publication Date: 2016-11-30
张小曦
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Therefore, such patients need long-term and regular plasma purification to ensure that the pathogenic factors are cleaned up in time. In addition, plasma purification therapy requires a lot of fresh plasma, high frequency, high price, and many complications: hypotension, allergic reactions, hemolysis, Hypertension, arrhythmia, etc.
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Embodiment 1
[0050] Embodiment 1 Plasma purification system of the present invention
[0051] Please refer to Figure 3-Figure 8 , image 3 is a schematic diagram of the carrier structure of the present invention, Figure 4 It is a schematic diagram of the pathogenic factor of the present invention through ligand-1 adsorption carrier, Figure 5 It is the working principle diagram of the present invention, Figure 6 It is a sectional view of the plasma adsorption and purification device of the present invention, Figure 7 is a sectional view of the adsorption column of the present invention, Figure 8 It is a sectional view of the adsorption column of the present invention.
[0052] The plasma purification system includes a carrier and an in vitro plasma purification device, the surface of the carrier adsorbs specific ligand-1 and specific ligand-2, the specific ligand-1 maintains its immunological activity, and the ligand-1 part Embedded on the surface of the carrier, it can specific...
Embodiment 2
[0058] Embodiment 2 myasthenia gravis plasma purification system
[0059] Taking the plasma purification treatment of myasthenia gravis as an example, the ligand-1 is 4-mercaptoethylpyridine, which can specifically adsorb the pathogenic factor (4), that is, the anti-acetylcholine receptor antibody (AchRab). First, an artificial carrier is prepared, and the carrier is composed of 4-mercaptoethylpyridine, polymer gel particles, and an envelope. The raw materials of polymer particles can be polyacrylamide gel, polyisopropylacrylamide, agar, alginate, chitosan, dextran, nitrocellulose, etc., with polyvinyl alcohol (PVA) hydrogel as the example.
[0060] (1) PVA can be prepared by radiation cross-linking, chemical agent cross-linking, repeated freezing and thawing and other methods: weigh PVA in proportion, take deionized water, stir together with PVA, and place it at a constant temperature of 85-90°C to dissolve completely , placed in a -20°C refrigerator for 24 hours, and then ...
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Abstract
The invention relates to a novel plasma purification system. The novel plasma purification system comprises a specific ligand-1 (immunoadsorbent) (1), a tissue compatibility carrier (3), a ligand-2 (2) and a plasma purification device. The specific ligand-1 still keeps the immunological activity, part of the ligand-1 is embedded into the surface of the carrier, the ligand-1 can be specifically combined with specific pathogenic factors (antibodies) in blood, therefore, a large quantity of the pathogenic factors keep a combined state, and only a few of pathogenic substances are dispersed in plasma in a free state. Carrier protein and the pathogenic factors are together removed regularly by specifically combining the plasma purification device with the ligand-2. According to the novel plasma purification system, the pathogenic factors in the blood can be specifically combined to enable the pathogenic factors to be in the combined state, therefore, the free-state pathogenic factors keep a low-concentration state for a long term, the tissue involvement degree is decreased, an 'immune storm' in a body is interrupted, the plasma purification frequency of a patient is decreased, and the complication incidence rate is decreased.
Description
technical field [0001] The invention relates to the field of medical technology, in particular to a novel plasma purification system and its application. Background technique [0002] Plasma purification therapy mainly refers to the removal of a large number of pathogenic substances in plasma in a short period of time, improving the clinical symptoms of patients, so as to achieve the purpose of treating diseases. At present, many technologies for selective filtration or adsorption removal of different pathogenic substances have been developed on this basis, including plasma exchange, double-filtration plasmapheresis (DFPP), cold filtration, thermal Filtration method, heparin-induced LDL precipitation method, plasma adsorption technology (plasmaabsorption, PA) and so on. The scope of technology application has also been expanded to hundreds of diseases in various systems. Patients with rheumatic immune diseases often have a variety of autoantibodies, complements, immune com...
Claims
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