Men's health care composition containing folic acid zinc gluconate and its preparation method

Abstract

The invention provides a male health composition containing folic acid and zinc gluconate, and a preparation method of preparations thereof. The health composition contains folic acid and zinc gluconate, and also contains sodium bicarbonate and a pharmaceutically acceptable auxiliary material; and a weight part ratio of folic acid to zinc gluconate to sodium bicarbonate is 0.2-0.8:35-70:100-500. The health composition can be used for preparing oral solid preparations not limited to a tablet, a capsule and a powder, improves the dissolution rate and the dissolution degree of folic acid and zinc gluconate, substantially reduces zinc gluconate induced gastrointestinal bad reaction, and improves the bioavailability of zinc gluconate.

Description

technical field [0001] The invention relates to a male health care composition containing zinc folic acid gluconate and a preparation method thereof, in particular to a health care composition with fast dissolution rate, high dissolution rate, small gastrointestinal adverse reactions and good bioavailability, belonging to the field of health care products . Background technique [0002] Premature ejaculation is a common sexual dysfunction disease, which not only affects the quality of sexual life of the patient, but also affects the normal life of the couple over time, causing mental anxiety, tension, and fear in the patient. Bad mental state will further aggravate premature ejaculation, and gradually make patients lose confidence and lack of energy, which seriously affects their quality of life and work. A number of research results at home and abroad have shown that the serum folic acid level of premature ejaculation patients is significantly lower than that of normal men...

AI Technical Summary

Problems solved by technology

Folic acid tablets usually have the problem of low dissolution rate. Therefore, in the 2010 edition of the Chinese Pharmacopoeia, the dissolution rate is only stipulated to be no less than 75% in 45 minutes. As we all know, the dissolution rate of active ingredients directly affects its bioavailability in vivo. affect the final outcome

Zinc gluconate tablets usually have nausea, vomiting and other gastrointestinal adverse reactions, and the clinical compliance is poor, which is related to the production of zinc chloride by zinc gluconate in the stomach; at the same time, the biological effects of zinc gluconate cannot be ignored. Utilization problem, usually the bioavailability of the active ingredient zinc to the human body is about 15%, resulting in a large loss of active ingredients in clinical applications, which cannot be effectively utilized by the human body

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