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Application of ozonization oil to cancer prevention

A technology for ozonation of oil and cancer, applied in medical preparations containing active ingredients, non-active ingredients of oil/fat/wax, drug delivery, etc., can solve the problem of unclear specific mechanism, difficulty in ensuring the effective concentration of gas entering the body, recurrence Problems with high probability of transfer

Inactive Publication Date: 2017-01-04
侯建生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The function of ozone gas may be realized through the following three ways: (1), ozone generates substances similar to active oxygen through biochemical reactions in the body (hydroxyl radical OH - , superoxide anion O 2 - etc.), extensively affects the redox system of the body; (2), ozone can cause the aggregation of endothelial progenitor cells and promote the generation of nitric oxide (NO), which can relax blood vessels; (3), ozone can induce bone marrow stem cells to At the site of vascular injury, it promotes the repair and reconstruction of damaged blood vessels, but the specific mechanism is still unclear
[0003] There are many defects in the above route of administration: contact with too many substances along the way, it is difficult to ensure the effective concentration of gas entering the body
Using surgery and radiotherapy, the side effects of the treatment are large, the probability of recurrence and metastasis is very high, and the survival rate is low
The problem is that surgery, chemotherapy, radiotherapy, biological therapy, etc., have unsatisfactory curative effects. At present, there are no effective western medicines and Chinese patent medicines. Chemically synthesized medicines have relatively large side effects, and the long-term curative effect is not good, so it is not easy to take them for a long time

Method used

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  • Application of ozonization oil to cancer prevention
  • Application of ozonization oil to cancer prevention
  • Application of ozonization oil to cancer prevention

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of ozonated olive oil enteric-coated capsules

[0030] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0031] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0032] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0033] 3. Put 3kg of olive oil into the reactor; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0034] 4. The obtained ozonated olive oil has a concentration of 40 mg / L and can be stored stably for ten months at 25°C.

[0035] 5. Preparation of ozonated olive oil enteric-coated capsules.

[0036] (1) Preparation of capsule material: Weigh water, gelatin, glycerin and glutinous rice flo...

Embodiment 2

[0039] Preparation of enteric-coated capsules of embodiment 2 ozonated olive oil, soybean oil and peanut oil mixed oil

[0040] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0041] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0042] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0043] 3. Put 1kg of olive oil, 1kg of soybean oil and 1kg of peanut oil into the reaction kettle; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0044] 4. The concentration of the obtained ozonated mixed oil is 40mg / L, and it can be stored stably for ten months at 25°C.

[0045] 5. Preparation of ozonated mixed oil enteric-coated capsules. ...

Embodiment 3

[0049] Example 3 Preparation of ozonated olive oil enteric-coated capsules containing surfactant

[0050] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0051] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0052] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0053] 3. Put 3kg of olive oil into the reaction kettle, slowly add 20mL of sorbitan monooleate polyoxyethylene ether (Tween 80), mix well, and use ozone at 150m 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0054] 4. The obtained ozonated olive oil has a concentration of 40 mg / L and can be stored stably for ten months at 25°C.

[0055] 5. Preparation of ozonate...

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Abstract

The invention relates to ozonization oil for cancer prevention and treatment and a combination drug with an anti-cancer drug. Particularly, the ozonization oil is used for preventing and treating liver cancer, lung cancer, stomach cancer, colorectal cancer, rectal cancer, esophagus cancer, breast cancer, cervical cancer, prostatic cancer, skin cancer and nasopharyngeal cancer by means of oral administration.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to administration of ozonated oil through oral route and administration by intraperitoneal injection, enema, gavage, intravenous injection, subcutaneous injection, intramuscular injection and suppository, which can be used for the preparation of prevention and treatment of various Drugs for cancer (cancer is selected from breast cancer, sarcoma, lung cancer, prostate cancer, colon cancer, rectal cancer, kidney cancer, pancreatic cancer, blood cancer, neuroblastoma, glioma, head cancer, neck cancer, thyroid cancer , liver cancer, ovarian cancer, vulvar cancer, cervical cancer, endometrial cancer, testicular cancer, bladder cancer, esophageal cancer, gastric cancer, nasopharyngeal cancer, buccal cancer, oral cancer, gastrointestinal stromal tumor, skin cancer, multiple myeloma) and in combination with other anticancer drugs. Background technique [0002] Velio Bocci in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/66A61K47/44A61P35/00
CPCA61K9/0019A61K9/0053A61K9/4808A61K9/4816A61K9/4858A61K33/00A61K47/44
Inventor 李新平侯建生
Owner 侯建生
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