Degradable drug eluting stent and preparation method thereof
A technology for eluting stents and drugs, applied in medical science, surgery, coating, etc., can solve the problems of blood vessel loss of elasticity and easy fracture, and achieve the effect of increasing mechanical strength and hardness
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[0042] The invention provides a method for preparing a degradable drug-eluting stent, comprising the following steps:
[0043] A) After heating the degradable high molecular polymer pipe to the deformation temperature, expand the degradable high molecular polymer pipe in the radial and / or axial direction of the degradable high molecular polymer pipe to obtain the expanded Tube;
[0044] The wall thickness of the expansion tube is not less than 80 μm; the radial expansion rate of the degradable polymer tube is 400% to 800%;
[0045] B) cutting the expansion tube to obtain a bare stent;
[0046] C) Coating the bare stent with a degradable drug coating after surface treatment to obtain a degradable drug-eluting stent.
[0047] In the invention, the degradable drug-eluting stent is prepared by using the degradable high molecular polymer tubing as a raw material. The present invention has no special limitation on the source of the degradable polymer pipe, which can be a commerci...
Embodiment 1
[0090] A PLLA pipe 1 with a weight-average molecular weight of 30W and an inner diameter of 0.44mm is placed in a glass tube with a precisely controlled inner diameter, and the pipe 1 is heated to 70°C with a heating nozzle, and then in the radial and / or radial direction of the degradable polymer pipe. Or expand the pipe in the axial direction, the axial stretching speed is 0.1mm / s, the axial stretching pressure is 90gr, the radial stretching speed is 0.1mm / s, the radial stretching pressure is 190psi, and the inner diameter is 2.5mm and an expansion tube 2 with a wall thickness of 90 μm. The radial expansion ratio of the expansion tube is 509%. Finally, the expansion tube is cooled and shaped.
[0091] Insert expansion tube 2 according to figure 2 The stent pattern was laser cut, and after cutting, it was cleaned with high-purity argon, ultrasonically cleaned with 100% ethanol for 3 minutes, dried at 30°C, and static electricity was removed by a static elimination device to...
Embodiment 2
[0097] A PLLA pipe 1 with a weight-average molecular weight of 40W and an inner diameter of 0.50 mm is placed in a glass tube with a precisely controlled inner diameter, and the pipe 1 is heated to 80°C with a heating nozzle, and then in the radial direction and / or direction of the degradable polymer pipe Or expand the pipe in the axial direction, the axial stretching speed is 0.2mm / s, the axial stretching pressure is 90gr, the radial stretching speed is 0.2mm / s, the radial stretching pressure is 200psi, and the inner diameter is 3mm And an expansion tube 2 with a wall thickness of 100 microns. The radial expansion rate of the expansion tube is 540%. Finally, the expansion tube is cooled and shaped.
[0098] Insert expansion tube 2 according to figure 2 The stent pattern was laser cut, and after cutting, it was cleaned with high-purity argon, ultrasonically cleaned with 100% ethanol for 3 minutes, dried at 30°C, and static electricity was removed by a static elimination dev...
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