Pharmaceutical composition containing sugar reducing medicine, aspirin and folic acid

An aspirin and composition technology, which is applied in the directions of drug combinations, medical preparations containing active ingredients, active ingredients of heterocyclic compounds, etc., can solve the problems of ignoring the early intervention of diabetic complications and the like

Inactive Publication Date: 2017-01-11
SHENZHEN AUSA PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Most of the anti-diabetic drugs currently on the market, no matter single or compound, focus on hypoglycemic treatment, while largely ignoring the early intervention of composite risk factors that lead to diabetic complications (such as diabetic vascular disease)

Method used

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  • Pharmaceutical composition containing sugar reducing medicine, aspirin and folic acid
  • Pharmaceutical composition containing sugar reducing medicine, aspirin and folic acid
  • Pharmaceutical composition containing sugar reducing medicine, aspirin and folic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Preparation of Compound Glimepiride / Aspirin / Folic Acid Tablets (1000 Tablets)

[0053] formula:

[0054]

[0055] Preparation:

[0056] The raw and auxiliary materials are crushed through an 80-mesh sieve, and dried for later use. Take the prescribed amount of glimepiride, aspirin, and folic acid and mix them uniformly according to the method of equal increase, add sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively according to the prescription amount, and mix uniformly according to the method of equal increase to obtain powder A ,spare. Dibasic calcium phosphate and lactose were passed through a 100-mesh sieve and dried at 75°C for 2 hours. Mix powder A with the mixed calcium hydrogen phosphate and lactose in equal increments. Add appropriate amount of povidone K30 aqueous solution binder to make soft material, granulate with 20-mesh sieve, dry at 40-45°C; dry granules are granulated with 20-mesh sieve. Add 1% magnes...

Embodiment 2～17

[0057] Examples 2-17 : the preparation of the compound tablet of different content proportioning (1000 pieces quantity)

[0058] The preparation method of Examples 2-17 is the same as that of Example 1, and the granules obtained according to the formula shown in Table 1 are made into tablets.

[0059] Table 1 embodiment 2~9 tablet formula composition

[0060]

[0061] Continuation of table 1 embodiment 10~17 tablet formula composition

[0062]

[0063]

Embodiment 18

[0064] Example 18 Preparation of Sitagliptin / Aspirin / Folic Acid Capsules (1000 Capsules)

[0065] formula:

[0066]

[0067] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 50g of sitagliptin, 75g of aspirin, and 0.8g of folic acid and mix them uniformly according to the equal increase method, add calcium hydrogen phosphate, lactose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively, and mix evenly according to the equal increase method , use povidone ethanol solution to make soft material, granulate with 20 mesh sieve, dry at 40°C for about 2 hours, granulate with 18 mesh sieve, control the water content of the granules to 2-3%, mix the dried granules with micro-powder silica gel Uniform, semi-finished products are tested, the content is measured, and filled into hollow capsules. Pay attention to avoiding light during the preparation process, and the prepared capsules nee...

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing a sugar reducing medicine, aspirin and folic acid, wherein the sugar reducing medicine is one of biguanide, sulfonylurea, thiazolidinedione, alpha-glycoside inhibitor or dipeptidyl peptidase IV (DPP-4) inhibitor medicines; and the aspirin content is preferably 50-150mg while the folic acid content is preferably 0.4-1.2mg. The invention also relates to an application of the composition in preparing a diabetes treatment medicine. A medicine prepared from the pharmaceutical composition provided by the invention has the beneficial effects of preventing or relieving vascular complications of diabetes on the basis of effectively reducing blood sugar, and thus is a more suitable anti-diabetic medicine.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing hypoglycemic drugs, aspirin and folic acid, which is used for treating diabetes and preventing diabetic vascular complications. The invention belongs to the field of medicine. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disease characterized by chronic hyperglycemia accompanied by disturbances in sugar, fat and protein metabolism caused by insufficient insulin secretion and / or action defects. According to epidemiological surveys, the prevalence of diabetes in my country is as high as 9.7%, and it is estimated that the total number of adult diabetic patients in the country is 92.4 million [Yang W, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010; 362: 1090-1101], type 2 diabetes mellitus (T2DM) accounts for more than 90%. In addition, according to the statistics of the International Diabetes Federation (IDF), there were...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/7036A61K31/64A61K31/616A61P3/10A61P9/10A61P7/02A61P13/12A61K31/519A61K31/4439A61K31/133A61K31/155A61K31/40A61K31/4985
CPCA61K45/06A61K31/133A61K31/155A61K31/40A61K31/4439A61K31/4985A61K31/519A61K31/616A61K31/64A61K31/7036A61K2300/00
Inventor 张磊于多徐希平刘平田敏卿
Owner SHENZHEN AUSA PHARM CO LTD
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