Preparation method of medicine composition containing naproxen
A technology of naproxen and its composition, which is applied in the field of fluidized bed production of naproxen direct-pressed granules, can solve the problems of slow disintegration and dissolution of naproxen tablets, improve the dissolution rate of drugs, and solve the problem of slow disintegration and dissolution , good effect of compression formability
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[0032] Example 1
[0033] Naproxen 420g
[0034] Lactose monohydrate 60g
[0035] Microcrystalline cellulose 60g
[0036] Crospovidone 24g
[0037] Hypromellose 30g
[0038] Magnesium stearate 6g
[0039] The preparation method is as follows:
[0040] 1) Pass the naproxen raw material through a 120-mesh sieve; the remaining auxiliary materials pass through an 80-mesh sieve;
[0041] 2) Preparation of the adhesive: According to the ratio of the mass of the adhesive to the volume of purified water at a ratio of 6:100, a 6% solution is prepared and placed on the constant temperature heating stirrer 6 to continue stirring;
[0042] 3) Weigh the processed naproxen, lactose, and microcrystalline cellulose according to the prescribed amount, and weigh and mix crospovidone according to 50% of the prescribed amount;
[0043] 4) Open the fluidized bed program, lock the air valve 12 of the sealed chamber, start the fan, and suck the mixed raw and auxiliary materials into the fluidized bed through the va...
Example Embodiment
[0050] Example 2
[0051] Naproxen 480g
[0052] Starch 48g
[0053] Croscarmellose Sodium 15g
[0054] Sodium Carboxymethyl Starch 15g
[0055] Hydroxypropyl cellulose 36g
[0056] Magnesium stearate 6g
[0057] Refer to Example 1 for the operation process, and the differences are as follows:
[0058] 1) Pass the naproxen raw material through a 120-mesh sieve; the remaining auxiliary materials pass through an 80-mesh sieve;
[0059] 2) Preparation of the adhesive: a 5% solution is prepared according to the ratio of the mass of the adhesive to the volume of purified water of 5:100;
[0060] 3) Weigh and mix the processed naproxen, starch, and sodium carboxymethyl starch according to the prescribed amount;
[0061] 4) The mixed raw and auxiliary materials are sucked into the fluidized bed, and the adhesive is sprayed into the top spray to granulate. The parameters are as follows:
[0062] Air volume (m 3 / h): 70-80
[0063] Atomization pressure (kg / cm 2 ): 1.3-1.5
[0064] Inlet air temperature (...
Example Embodiment
[0068] Example 3
[0069] Naproxen 540g
[0070] Croscarmellose Sodium 12g
[0071] Low-substituted hydroxypropyl cellulose 12g
[0072] Povidone K30 31.2g
[0073] Colloidal silica 2g
[0074] Talc 2.8g
[0075] Refer to Example 1 for the operation process, and the differences are as follows:
[0076] 1) Pass the naproxen raw material through a 120-mesh sieve; the remaining auxiliary materials pass through an 80-mesh sieve;
[0077] 2) Preparation of the adhesive: According to the ratio of the quality of the adhesive to the volume of purified water of 8:100, it is formulated into an 8% solution;
[0078] 3) Weigh and mix the processed naproxen and low-substituted hydroxypropyl cellulose according to the prescription amount;
[0079] 4) The mixed raw and auxiliary materials are sucked into the fluidized bed, and the adhesive is sprayed into the top spray to granulate. The parameters are as follows:
[0080] Air volume (m 3 / h): 70-80
[0081] Atomization pressure (kg / cm 2 ): 1.3-1.5
[0082] Inl...
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