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Preparation method of medicine composition containing naproxen

A technology of naproxen and its composition, which is applied in the field of fluidized bed production of naproxen direct-pressed granules, can solve the problems of slow disintegration and dissolution of naproxen tablets, improve the dissolution rate of drugs, and solve the problem of slow disintegration and dissolution , good effect of compression formability

Inactive Publication Date: 2017-02-01
JIANGSU ZHONGBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention improves production efficiency, improves drug dissolution rate, and solves the problem of slow disintegration and dissolution of naproxen tablets

Method used

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  • Preparation method of medicine composition containing naproxen
  • Preparation method of medicine composition containing naproxen
  • Preparation method of medicine composition containing naproxen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Naproxen 420g

[0034] Lactose monohydrate 60g

[0035] Microcrystalline Cellulose 60g

[0036] Crospovidone 24g

[0037] Hypromellose 30g

[0038] Magnesium Stearate 6g

[0039] The preparation method is as follows:

[0040] 1) Pass the naproxen bulk drug through a 120-mesh sieve; pass the remaining auxiliary materials through an 80-mesh sieve;

[0041] 2) Preparation of the adhesive: prepare a 6% solution according to the volume ratio of the mass of the adhesive to the purified water of 6:100, and place it on the constant temperature heating stirrer 6 to continue stirring;

[0042] 3) weigh the processed naproxen, lactose, and microcrystalline cellulose according to the prescription quantity, and weigh and mix crospovidone according to 50% of the prescription quantity;

[0043] 4) Start the fluidized bed program, lock the air valve 12 in the sealing chamber, start the fan, and suck the mixed raw and auxiliary materials into the fluidized bed through the vacuum s...

Embodiment 2

[0051] Naproxen 480g

[0052] Starch 48g

[0053] Croscarmellose Sodium 15g

[0054] Sodium carboxymethyl starch 15g

[0055] Hydroxypropyl Cellulose 36g

[0056] Magnesium Stearate 6g

[0057] Operation process with reference to embodiment 1, difference is as follows:

[0058] 1) Pass the naproxen bulk drug through a 120-mesh sieve; pass the remaining auxiliary materials through an 80-mesh sieve;

[0059]2) Preparation of adhesive: prepare a 5% solution according to the volume ratio of the mass of adhesive to purified water of 5:100;

[0060] 3) The processed naproxen, starch, sodium carboxymethyl starch are weighed and mixed according to the prescription quantity;

[0061] 4) Inhale the mixed raw and auxiliary materials into the fluidized bed, spray the adhesive into the granulation by top spraying, the parameters are as follows:

[0062] Air volume (m 3 / h): 70-80

[0063] Atomization pressure (kg / cm 2 ): 1.3-1.5

[0064] Inlet air temperature (℃): 75-80

[0065...

Embodiment 3

[0069] Naproxen 540g

[0070] Croscarmellose Sodium 12g

[0071] Low-substituted hydroxypropyl cellulose 12g

[0072] Povidone K30 31.2g

[0073] Colloidal silicon dioxide 2g

[0074] Talc powder 2.8g

[0075] Operation process with reference to embodiment 1, difference is as follows:

[0076] 1) Pass the naproxen bulk drug through a 120-mesh sieve; pass the remaining auxiliary materials through an 80-mesh sieve;

[0077] 2) Preparation of the adhesive: prepare an 8% solution according to the volume ratio of the mass of the adhesive to the purified water of 8:100;

[0078] 3) weigh and mix the processed naproxen and low-substituted hydroxypropyl cellulose according to the prescription quantity;

[0079] 4) Inhale the mixed raw and auxiliary materials into the fluidized bed, spray the adhesive into the granulation by top spraying, the parameters are as follows:

[0080] Air volume (m 3 / h): 70-80

[0081] Atomization pressure (kg / cm 2 ): 1.3-1.5

[0082] Inlet air te...

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Abstract

The invention discloses a preparation method of a medicine composition containing naproxen and relates to the field of pharmacy. According to a prescription, the medicine composition is composed of naproxen raw material medicine and medicinal auxiliary materials such as a diluting agent, a disintegrating agent, adhesive and a lubricating agent, through a method that spraying granulating is carried out on a fluidized bed, the three procedures of mixing, granulating and drying in a traditional technology are completed at a time, in this way, production efficiency is improved, and produced particles are even in particle size and good in flowability and compression forming; the particles produced through the fluidized bed are pressed into tablets, and therefore compared with a wet-method granulating technology, the medicine dissolution rate of the tablets is obviously increased.

Description

technical field [0001] The invention relates to the field of pharmacy, discloses a pharmaceutical composition containing naproxen, and also discloses a fluidized-bed production method of direct-pressing granules of naproxen. Background technique [0002] Naproxen is a non-steroidal anti-inflammatory analgesic, which has strong antipyretic, analgesic and anti-inflammatory effects, and can inhibit the synthesis of prostaglandins to exert anti-inflammatory and analgesic effects. It is clinically applicable to the treatment of fever and pain caused by various reasons. It is often used to treat rheumatism and rheumatoid arthritis, gastric arthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis and other diseases. It can also be used to relieve muscle pain. Pain from bone sprains, bruises, injuries, and dysmenorrhea. The peak plasma concentration is reached 15 minutes after intravenous injection, and the half-life is 12-14 hours. Its notable feature is its low toxicity...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/192A61K47/38A61K47/32A61P29/00
CPCA61K9/2095A61K9/2027A61K9/2054A61K31/192
Inventor 徐强夏彬许林菊杨健王飞
Owner JIANGSU ZHONGBANG PHARMA
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