A kind of mefenamic acid and its synthesis process

A technology of mefenamic acid and synthesis process, applied in the field of porous mefenamic acid and its synthesis process, can solve the problems of low yield, long reaction time, irritation and the like of the synthesis process, and achieves high bulk density and improved yield , reduce the effect of hydrolysis

Active Publication Date: 2018-07-03
西安利君精华药业有限责任公司
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Problems solved by technology

The synthesis process yield is low, and the reaction time is long, the dioxane used is an explosive liquid, the explosion limit in air is 2-22%, and the preparation process is irritating to the skin and lung mucous membranes, which can cause severe poisoning. liver, kidney damage

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  • A kind of mefenamic acid and its synthesis process
  • A kind of mefenamic acid and its synthesis process

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Embodiment Construction

[0049] The present invention will be further described in detail below in conjunction with the embodiments, so that those skilled in the art can implement it with reference to the description.

[0050] It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0051] The present invention provides a kind of mefenamic acid, and this mefenamic acid is reactant with o-chlorobenzoic acid and 2,3-dimethylaniline, and is used as acid-binding agent in the catalysis of copper catalyst and weak basic salt Under the condition of , it is obtained by C-N condensation reaction, and its reaction equation is:

[0052]

[0053] Wherein, the copper catalyst is copper 8-hydroxyquinolate. Copper catalyst can improve the selectivity of C-N condensation reaction. And the weakly basic salt is sodium acetate.

[0054] For said mefenamic acid, the present invention...

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Abstract

The invention discloses a mefenamic acid. The mefenamic acid is prepared by the following steps: taking o-chlorobenzoic acid and 2,3-dimethylaniline as the reactants and weakly alkaline salt as the acid binding agent, and then carrying out C-N condensation reactions in the presence of a copper catalyst. The invention also provides a synthesis technology of mefenamic acid. The synthesis technology comprises the following steps: adding 2,3-dimethylaniline, strongly acidic cation exchange resin, o-chlorobenzoic acid, sodium bicarbonate, a copper catalyst, sodium acetate, and sodium ethyl benzene sulfonate into a condensation reaction tank to synthesize a first reaction liquid; then sequentially adding o-chlorobenzoic acid, sodium bicarbonate, and a copper catalyst into the first reaction liquid, dropwise adding liquid alkali to synthesize a second reaction liquid, adjusting the pH value of the second reaction liquid to obtain a condensation liquid, and finally subjecting the condensation liquid to filtering, decoloring, and purification to obtain mefenamic acid. The provided mefenamic acid synthesis technology has the advantages of few byproducts, high yield, safety, environment-friendliness, energy saving, improved efficiency, and simple operation.

Description

technical field [0001] The invention relates to the technical field of mefenamic acid, more specifically, the invention relates to a porous mefenamic acid and a synthesis process thereof. Background technique [0002] Mefenamic acid, also known as: mefenamic acid, flutter. The chemical composition is N-[(2,3-xylyl)amino]-benzoic acid, molecular formula: C 15 h 15 NO 2 , has analgesic, antipyretic and anti-inflammatory effects, used for mild and moderate pain, such as pain after dental, obstetric or orthopedic surgery, etc., widely used in various departments of hospitals, but the existing mefenamic acid There are many problems in the synthesis process, such as harsh pH requirements leading to easy decomposition of raw materials, low reaction selectivity resulting in many by-products, a large amount of jelly in the cooking process after the condensation reaction is over, and low yield due to clogging of the bottom of the tank. The refined section adopts water-refined prod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/08C07C229/58
CPCC07C227/08C07C229/58
Inventor 王锋怀
Owner 西安利君精华药业有限责任公司
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