53 results about "Chlorobenzoic Acids" patented technology

The invention belongs to the field of preparation of halogen-containing substituted benzoic acid, and particularly relates to a method for preparing o-chlorobenzoic acid through hydrogenation selective debromination. According to the invention, hydrogen is used as a reducing agent, a palladium catalyst is used as a catalyst, a methanol aqueous solution is used as a solvent, and 2-chloro-3-bromobenzoic acid, 2-chloro-5-bromobenzoic acid or a mixture thereof are used as raw materials to prepare o-chlorobenzoic acid. According to the method, debromination is controlled through selective hydrogenation instead of dechlorination, so that generation of a byproduct benzoic acid is inhibited. The scheme is reasonable in design, simple in process and mild in reaction condition, and a new thought is provided for the synthesis method of o-chlorobenzoic acid.

The present invention discloses a process for preparing m-chloroperbenzoic acid by using a molecular sieve catalyst, belonging to the technical field of chemical catalytic preparation, and comprising the following steps: S1, dissolving m-chlorobenzoic acid in an organic solvent, adding the molecular sieve catalyst, uniformly stirring, and then dropwise adding an aqueous oxidant solution with a mass fraction of 15% to 30% for an oxidation reaction; S2, after the oxidation reaction is completed, separating the molecular sieve by using a filter for the next reaction; S3, after separation, extracting and separating the organic phase, distilling and recovering the organic solvent to obtain m-chloroperbenzoic acid crystals. The present invention overcomes the defects and deficiencies in the existing process methods, such as low effective yield and serious wastewater pollution. A solid molecular sieve is used as the catalyst. The catalyst has stable properties, simple separation, the solvent can be recycled and reused in the process, the product yield is high, environmental problems caused by other oxidation methods are avoided, and it is beneficial to large-scale industrial production.

The invention relates to a dapagliflozin impurity and a preparation method thereof, 5-bromo-2-chlorobenzoic acid (IV) is used as a raw material, (5-bromo-2-chlorphenyl) (4-ethyoxyl phenyl) ketone (III) is prepared through chlorination and Friedel-Crafts acylation, (5-bromo-2-chlorphenyl) (4-ethyoxyl phenyl) methanol (II) is obtained through reduction, and the benzhydryl ether impurity (I) is obtained through condensation under the catalysis of iodine. The preparation method has the advantages of simple operation, low cost, easily available raw materials and good product purity.

The application belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of furosemide. The preparation method of furosemide comprises the following steps: chlorosulfonation: reacting chlorosulfonic acid and 2,4-dichlorobenzoic acid, hydrolyzing, filtering, and obtaining 2,4-dichloro-5-sulfonyl chlorobenzoic acid; amination: adding 2,4-dichloro-5-sulfonyl chlorobenzoic acid into ammonia water, reacting, neutralizing, filtering, purifying, and obtaining 2,4-dichloro-5-sulfonamidobenzoic acid; condensation: reacting 2-furfurylamine and 2,4-dichloro-5-sulfonamidobenzoic acid, and obtaining furosemide crude product; decolorization: adding the furosemide crude product into a saturated sodium bicarbonate solution, adding activated carbon for decolorization, neutralizing, and crystallizing, and thus furosemide product is obtained. The raw material used in the application is easy to obtain and low in price, the comprehensive reaction period is short, the amount of hazardous waste generated is small, the prepared furosemide is high in purity and high in total yield, the comprehensive cost of the whole preparation process is low, and the application is suitable for industrial production.

This invention belongs to the field of organic electrochemical synthesis and microchemical technology, and relates to a method for preparing 2-chlorobenzoic acid by electrochemical reduction debromination in a continuous flow microreactor. The method includes: dissolving 3-bromo-2-chlorobenzoic acid, a supporting electrolyte, and a proton source in a polar aprotic solvent to prepare a cathode reaction solution; continuously feeding this solution into the cathode channel of a microchannel electrochemical reactor using a metering pump, while simultaneously pumping the anolyte into the anode channel; connecting a DC power supply and conducting a selective electrochemical debromination reaction under set current density, reaction temperature, and material residence time conditions; and obtaining high-purity 2-chlorobenzoic acid from the outlet material through gas-liquid separation, neutralization, extraction, and recrystallization. This invention combines a continuous flow microreactor with electrochemical debromination technology, significantly enhancing mass and heat transfer, resulting in a shorter reaction time, higher conversion and yield, and the addition of a reducing agent, ease of scale-up, and intrinsic safety, demonstrating promising industrial application prospects.

The invention provides a method for recovering an effective ingredient in p-chlorobenzaldehyde wastewater, including the preparation, refinement and wastewater recovery process of p-chlorobenzaldehyde, wherein the preparation of p-chlorobenzaldehyde includes chlorination reaction, hydrolysis reaction and neutralization reaction, the oily substance after the neutralization reaction enters the p-chlorobenzaldehyde refining process, the wastewater after the neutralization reaction enters the recovery process, the wastewater after the p-chlorobenzaldehyde neutralization reaction is passed into an oxidation reactor in the recovery process, an active oxidant is provided in the oxidation reactor, the oxidant is instantly generated as the wastewater is passed, and the p-chlorobenzaldehyde in the wastewater is oxidized to p-chlorobenzoic acid. The wastewater of p-chlorobenzaldehyde is used for the production and preparation of p-chlorobenzoic acid, the p-chlorobenzoic acid in the wastewater is recovered, and the effective ingredient p-chlorobenzaldehyde therein is converted into p-chlorobenzoic acid simultaneously, reducing wastewater treatment pressure, reducing pollution to the environment, and avoiding waste of materials.

The application provides a preparation method of bumetanide, taking p-chlorobenzoic acid as a starting material, performing chlorosulfonation, nitration, and ammonolysis to obtain a key intermediate of 3-(N-(tert-butyl) sulfamoyl)-4-chloro-5-nitrobenzoic acid, then performing phenoxylation, nitro reduction, n-butylation, and tert-butyl removal, and finally obtaining the bumetanide. Compared with the synthesis process of the prior art, the method has less side reactions, low cost, high yield, high safety, and is beneficial to industrial production.

The invention relates to the fields of chemistry and chemical engineering, organic synthesis and medicinal chemistry, in particular to a method for synthesizing 5-bromo-2-chlorobenzoic acid by adopting a microchannel reaction device. The method comprises the following steps: I, mixing 2-chlorobenzoic acid and sulfuric acid to obtain a reaction solution A; mixing bromine, sodium periodate, liquid organic acid and water to obtain a reaction solution B; and II, feeding the reaction liquid A and the reaction liquid B into a micro mixer of a micro-channel reaction device for mixing, then feeding the mixture into a micro reactor of the micro-channel reaction device for contact reaction, and carrying out post-treatment on contact reaction effluent to obtain the 5-bromo-2-chlorobenzoic acid. The method has the advantages of high product selectivity, high yield, high purity, convenient process, low production cost, and less by-product and three-waste pollution.

The invention provides a system for separating p-chlorobenzaldehyde and p-chlorobenzoic acid. The system comprises a crystallization tank, a circulating material tank, a desublimation tank, a temperature control device and a finished product tank. A plurality of coil pipes are arranged in the crystallization tank, the outer wall is wrapped by a jacket, and the top and the bottom are respectively provided with an upper air inlet and a lower air inlet; a plurality of devitrification plates are arranged in the desublimation tank, and a discharge port is formed in the bottom; and the temperature control device is used for regulating and controlling the temperatures of the coil pipe, the jacket and the devitrification disc. Based on the system, the p-chlorobenzoic acid is crystallized from p-chlorobenzaldehyde at a proper temperature by utilizing the solidification and sublimation characteristics of p-chlorobenzaldehyde and p-chlorobenzoic acid, then the p-chlorobenzoic acid is sublimated to the desublimation tank for desublimation by heating according to the sublimation characteristic of p-chlorobenzoic acid, and the two materials are separated in such a manner, so that the quality of p-chlorobenzoic acid is improved, and the quality of p-chlorobenzoic acid is improved. The purity of p-chlorobenzaldehyde is improved, the purity of p-chlorobenzoic acid is high after separation, no water or other solvents are added, no other hazardous waste is generated, operation is easy and convenient, and the purpose of clean production is achieved.

The invention provides a preparation method of a 2-amino-3-methyl-5-chloro-benzoic acid compound, which comprises the following synthesis route: wherein the definitions of R1 and R2 are the same as those in the specification.

The invention discloses a continuous synthesis method of 1-(2-chlorphenyl)-2-(2-tetrazolyl) ethanone, which comprises the following steps: (1) introducing a trimethylsilylated diazomethane solution and a strong alkali solution into a micro-channel reactor 1 for reaction, introducing the obtained intermediate reaction solution and a 2-chloromethyl benzoate solution into a micro-channel reactor 2 for continuous reaction, the preparation method comprises the following steps: adding 2-chlorophenyl to generate 1-(2-chlorophenyl)-2-(2-tetrazolyl-trimethylsilane) ethanone; and (2) removing a TMS group from the 1-(2-chlorphenyl)-2-(2-tetrazolyl-trimethylsilane) ethanone, and then carrying out post-treatment to obtain the 1-(2-chlorphenyl)-2-(2-tetrazolyl) ethanone. The continuous synthesis method uses a fluid process, has the advantages of small amplification effect, high production efficiency and environmental protection, improves the selectivity of 2-tetrazole, and avoids partial sensitization of intermediates.

The application belongs to the technical field of medical intermediates, and relates to a production method of a clotrimazole intermediate (2-chlorophenyl)diphenylmethanol. In the method, 2-methyltetrahydrofuran or cyclopentyl methyl ether is used as a reaction solvent, an ethyl o-chlorobenzoate solution is added dropwise into a phenyl magnesium bromide solution with a concentration of 2.5-3.5 M under the conditions of 60-80 DEG C and inert atmosphere, the reaction is continuously carried out after the dropwise addition is completed, a water solution of a quenching agent is added after the reaction to quench, then, liquid separation is carried out, and the organic phase after the liquid separation is concentrated to obtain a crude product; the crude product is refined by using a reaction solvent and petroleum ether, and (2-chlorophenyl)diphenylmethanol is obtained. The production method can efficiently and stably produce high-quality (2-chlorophenyl)diphenylmethanol, reduces production cost and safety hazards, and can be used for large-scale industrial production.

The invention provides a novel N / P co-coordinated Co-Mn bimetallic monatomic catalytic ozonation water quality purification method, which comprises the following steps: mixing an N / P co-coordinated Co-Mn bimetallic monatomic catalyst with water to be treated, and carrying out ozone aeration, the N / P co-coordinated Co-Mn bimetal monatomic catalyst comprises a carrier and active sites loaded on the carrier, wherein the active sites comprise N / P co-coordinated Co-Mn bimetal monatomic sites. According to the method, rapid removal of various refractory organic micropollutants, such as acetaminophen, sulfamethoxazole, parachlorobenzoic acid and nitrobenzene, can be realized, and the retention time of the reaction can be reduced while the dosage of the ozone catalyst is reduced.

The invention discloses a method for preparing an S-isomer of montelukast sodium, which belongs to the technical field of chemical raw material medicines, and is characterized by comprising the following steps: dissolving a starting material montelukast sodium mother nucleus in an organic solvent, and carrying out configuration inversion under the action of an initiator and the catalysis of a composite catalyst to generate the S-isomer of the montelukast sodium mother nucleus; and adding 1-mercaptomethyl cyclopropyl acetic acid, reacting under the catalysis of a catalyst, filtering, cooling, growing crystal, carrying out suction filtration and drying to obtain the montelukast S-isomer. The preparation method has the beneficial effects that azodiisobutyronitrile is creatively used as an initiator, and under the catalysis of a composite catalyst tributylphosphine and m-chlorobenzoic acid, a montelukast mother nucleus is subjected to an isomerization reaction to obtain a montelukast mother nucleus S-isomer; and reacting with 1-mercaptomethyl cyclopropyl acetic acid under the catalysis of H < + >-montmorillonite to obtain the S-isomer of montelukast sodium.

The invention relates to application of m-chlorobenzoic acid in promoting growth of panax notoginseng and preventing and treating diseases. It is found that m-chlorobenzoic acid has a good pseudo-ginseng fusarium and rust rot fungus inhibiting effect, and therefore m-chlorobenzoic acid can be used for preventing and treating pseudo-ginseng root rot. In addition, the invention also finds that m-chlorobenzoic acid can promote the growth of beneficial bacteria such as trichoderma and penicillium. Therefore, after the metachlorobenzoic acid is applied to the panax notoginseng, the metachlorobenzoic acid can promote seedling storage of annual panax notoginseng, increase the dry weight of single plants of the overground part and the underground part of the panax notoginseng and promote growth of fibrous roots of the panax notoginseng.

The invention relates to the technical field of o-chlorobenzoic acid preparation, in particular to a method for preparing o-chlorobenzoic acid through electrochemical selective debromination. The method comprises the following steps: (1) taking a sulfuric acid aqueous solution as anolyte and a sodium hydroxide aqueous solution as catholyte; adding a reaction raw material chlorobromobenzoic acid into the cathode liquor, uniformly mixing, and carrying out electrolytic debromination; (2) adjusting the pH value of the reacted catholyte to be acidic, separating to obtain a solid and an acid solution, and washing and drying the solid to obtain a white filter cake, namely o-chlorobenzoic acid; and (3) carrying out electrodialysis dissociation on the obtained acid liquor to respectively obtain sodium hydroxide and recovered acid liquor. According to the method, chlorobromobenzoic acid is adopted as a raw material to carry out electrochemical selective debromination to prepare o-chlorobenzoic acid, and the raw material chlorobromobenzoic acid is only debrominated but not dechlorinated through accurate control of electrodes, electrolyte and electrolysis conditions.

The invention provides a preparation method of 4-chloro-6, 7-dihydro-5H-cyclopenta [B] pyridine-7-alcohol, and relates to the technical field of organic synthesis. A compound 1 and first m-chloroperoxybenzoic acid are subjected to a first oxidation reaction to obtain a compound 2 crude product, the compound 2 crude product and acid anhydride are directly subjected to a Boekelhede reaction to obtain a compound 3, the water solubility of the compound 3 is poor, the compound 3 is easily separated from a water-soluble byproduct m-chlorobenzoic acid, and a large amount of loss of the compound 3 in the subsequent separation process cannot be caused; the yield of the compound 3 is improved; and carrying out a second oxidation reaction on the compound 3 and second m-chloroperoxybenzoic acid, carrying out a chlorination reaction on the obtained compound 4 and phosphorus oxychloride, and carrying out a hydrolysis reaction on the obtained compound 5 to obtain the 4-chloro-6, 7-dihydro-5H-cyclopenta [B] pyridine-7-ol. According to the preparation method provided by the invention, the total yield of the 4-chloro-6, 7-dihydro-5H-cyclopenta [B] pyridine-7-alcohol is high.

The application discloses a synthesis process of chlorobenzoic acid, and the NiMo-Sb2O3 / TiO2-CeO2-MgO composite catalyst prepared by the method can better prepare ortho-chlorotoluene, has high selectivity and long service life, and has mild process conditions and small carbon deposition amount, so that the application has important significance for improving product quality, reducing production cost and promoting green development of the industry.

The present invention discloses the preparation and application of a cannabinoid monoclonal antibody, belonging to the field of biotechnology. The specific steps for the preparation of the cannabinoid monoclonal antibody include: (1) hapten preparation: reacting a cannabinoid molecule with methyl 4-chlorobenzoate to obtain the hapten; (2) complete antigen preparation: coupling the hapten with hemocyanin to obtain the complete antigen. The present invention prepares the complete antigens of tetrahydrocannabinol, cannabigerol or cannabidiol, further prepares the corresponding monoclonal antibodies, and then uses the prepared monoclonal antibodies to prepare a colloidal gold test strip. The prepared colloidal gold test strip has strong specificity and high sensitivity. The complete antigen is obtained by coupling a tetrahydrocannabinol, cannabigerol or cannabidiol molecule with hemocyanin.

The application discloses a high-temperature-resistant and salt-resistant polymer additive for oil drilling, which is prepared by the following method: S1, carrying out nucleophilic addition on ferrocene formaldehyde and 5-amino-2-chlorobenzoic acid; S2, adding a reducing agent to the system to reduce the intermediate 1; S3, adding a catalyst to carry out aromatic nucleophilic substitution reaction under the condition of strong base and high temperature; S4, finally, carrying out esterification reaction with methacryloyl chloride; and S5, carrying out reaction on the synthetic monomer, acrylamide monomer and alkenyl monomer to obtain the polymer. The application introduces the amphiphilic macromolecular benzene ring into the main chain by reasonably controlling the process, so that the prepared additive has the advantages of less by-product, stable performance, good filtration loss reduction effect, excellent temperature resistance and salt resistance.

The invention discloses a synthesis method of (R)-1-(2-bromine-4-chlorphenyl)-2, 2, 2-trifluoroethanol, and relates to the technical field of organic synthesis.The synthesis method comprises the steps that 2-bromine-4-chlorobenzoic acid methyl ester serves as a raw material, trifluoromethylation is conducted on the 2-bromine-4-chlorobenzoic acid methyl ester, and a 2-bromine-4-chlorphenyl trifluoroethanone acetal intermediate solution is obtained; the preparation method comprises the following steps: preparing a 2-bromo-4-chlorophenyl trifluoroethanone acetal intermediate solution, carrying out ketal deprotection on the 2-bromo-4-chlorophenyl trifluoroethanone acetal intermediate solution to obtain 2-bromo-4-chlorophenyl trifluoroethanone, and carrying out chiral reduction synthesis on the 2-bromo-4-chlorophenyl trifluoroethanone to obtain (R)-1-(2-bromo-4-chlorophenyl)-2, 2, 2-trifluoroethanol. The method is low in cost, easy to operate and implement, high in yield and stable in product property.

An antibiotic therapeutic composition or method of treatment includes administering a beta-lactamase inhibitor in combination with a beta-lactam antibiotic. The beta-lactamase inhibitor can be a boronic-acid, a boronic-ester beta-lactamase inhibitor, carboxyl-group beta-lactamase inhibitors, halogen-terminated heterocyclic group beta-lactamase inhibitors, or any pharmaceutically acceptable salts thereof. In combination, the beta-lactamase inhibitors and beta-lactam antibiotics can inhibit the growth of bacteria that are resistant to the beta-lactam antibiotics alone. According to additional embodiments, the effectiveness of various combinations of compounds including various antibiotics and compounds selected from the group consisting of 5-Carboxythiophene-2-boronic acid pinacol ester, 5-Carboxy-2-fluorophenylboronic Acid, 3-Amino-5-carboxylphenylboronic acid, 5-Carboxy-2-chlorophenylboronic acid, 3-Carboxy-2-fluorophenylboronic acid, 5-dehydroxyboryl-2-thiophenecarboxylic acid, and 5-Borono-2-chlorobenzoic acid is demonstrated. Particularly, when combined with certain antibiotics, each of these compounds demonstrates enhanced effectiveness against bacteria and bacterial infections even where the bacteria are known to be resistant to the beta-lactam antibiotics.

The utility model discloses equipment for producing o-chlorophenylacetic acid through carboxylation of o-chlorobenzyl chloride, and relates to the technical field of preparation of o-chlorophenylacetic acid. The device comprises a bottom box, a connecting ring plate is arranged over the bottom box, a heating opening is formed in the middle of the upper end face of the bottom box, a processing cylinder with the lower end located at the heating opening is arranged in the connecting ring plate, a containing ring is arranged between the connecting ring plate and the bottom box, and a plurality of notches annularly and evenly distributed along the circumferential side are formed in the circumferential side wall of the containing ring. Test tubes are arranged in the notches, and positioning rings are arranged at the upper ends of the test tubes above the placing rings in a sleeving manner. The plurality of test tubes are arranged on the peripheral side of the processing cylinder and used for containing different solvents, so that the different solvents can be conveniently put for reaction activities, and meanwhile, the upper end parts of the test tubes are limited by the positioning rings, so that the test tubes are stably placed.

The invention relates to the technical field of building materials, and particularly discloses a first-aid repair material for an emergency rescue channel and a preparation method of the first-aid repair material. The first-aid repair material for the emergency rescue channel disclosed by the invention specifically comprises the following components in parts by weight: 0.8-1.2 parts of a hydrophobic polyurethane material and 1-20 parts of aggregate, the hydrophobic polyurethane material is formed by mixing grease polyol, hydrophobic isocyanate, a catalyst, a plasticizer and a chain extender according to the weight ratio of 100: (50-150): (0.1-1.0): (5-50): (5-15); the chain extender is selected from one or more of 3, 5-diamino parachlorobenzoic acid isobutyl ester, ethanol amine and diethanol amine; the aggregate is selected from one or more of sand, stone and soil. According to the technical scheme, the emergency rescue channel repair material which is short in curing time, high in compression strength and high in bonding strength is obtained.

The invention discloses a tail gas treatment device for o-chlorobenzonitrile production, and relates to the technical field of waste gas treatment. According to the tail gas treatment device for o-chlorobenzonitrile production, through cooperation of the middle partition plates and the filter cartridges, when waste gas enters the machine body, spraying treatment can be carried out while the waste gas is conveyed along the multiple middle partition plates, large-particle impurities in the waste gas are removed, the contact uniformity of the waste gas and spraying water is improved, and the service life of the waste gas is prolonged. And in the use process, the replacement, desorption and drying operations of the filter cartridge and the filter module can be automatically completed, so that the treatment effect of the waste gas is improved while continuous operation is ensured, and the maintenance convenience of the equipment is improved.

The present invention discloses a diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry of formula 3 and its synthesis method and application in an asymmetric catalytic reaction, wherein C2-symmetry is lost by introducing different groups into the diphenylamine backbone to realize precise control of “electronic effect” of the ligand backbone. An anthranilic acid derivative and an orthochlorobenzoic acid derivative are used as starting materials to prepare a compound of formula 1, and then the compound of formula 1 is reacted with a chiral amino alcohol compound to prepare a β-bishydroxy amide compound of formula 2, and the compound of formula 2 is further subjected to condensation to obtain the diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry of formula 3. The present invention also provides an application of a catalyst formed by coordination of the diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry with copper salt, zinc salt, nickel salt, iron salt or rhodium salt, in an asymmetric catalytic reaction.

The invention relates to a preparation method of light-color 3, 5-diamino-4-chlorobenzoic acid isobutyl ester with stable storage, which comprises the following steps: carrying out hydrogenation reduction on 3, 5-dinitro-4-chlorobenzoic acid isobutyl ester under the conditions that noble metal is used as a catalyst and hydrogen is used as a reducing agent to obtain the 3, 5-diamino-4-chlorobenzoic acid isobutyl ester, filtering the hydrogenation catalyst and recycling, and carrying out solid-liquid separation to obtain the 3, 5-diamino-4-chlorobenzoic acid isobutyl ester. The preparation method comprises the following steps: filtering the raw materials to obtain a filtrate, distilling the filtrate out of a solvent, cooling and crystallizing to obtain a crude product of 3, 5-diamino-4-chlorobenzoic acid isobutyl ester, oxidizing the crude product by using an oxidizing agent / ultraviolet light, and distilling to finally obtain light-colored 3, 5-diamino-4-chlorobenzoic acid isobutyl ester. The preparation process is simple and convenient, and the 3, 5-diamino-4-chlorobenzoic acid isobutyl ester obtained by the method is light in color, is not easy to discolor in the storage process, and can be used for preparing light-color polyurethane workpieces.

The application discloses a preparation method of a quetiapine intermediate, which comprises the following steps: taking o-aminothiophenol potassium salt as a starting material, condensing with o-chlorobenzoic acid, then performing intramolecular cyclization, and refining to obtain a target compound, i.e. dibenzo[b,f][1,4]thiazepine-11-[10H] ketone. The application optimizes process operation steps, is more convenient to operate, is safer under milder reaction conditions, has fewer side reactions, improves yield, and has a total yield of more than 85%. The obtained product is high in purity, good in quality, friendly to environment, low in pollution, and low in production cost, and is more suitable for industrial production.

The invention provides a packaged urinary catheter comprising: a urinary catheter comprising a hollow polymeric tubular body comprising a base polymer and an amphiphilic lubricious additive, the additive comprising an A-B block copolymer comprising a hydrophobic hydrocarbon A-block and a hydrophilic B-block; and an aqueous liquid medium comprising at least one species that is independently chosen from: a citric acid or citrate buffer, polyvinylpyrrolidone (PVP), polypropylene, glycerol, lactic acid, itaconic acid, succinic acid, tartaric acid, carbonic acid, ethanoic acid, boric acid, sorbic acid, mandelic acid, malic acid, propionic acid, hippuric acid, benzoic acid, pyruvic acid, formic acid, glycolic acid, m-chlorobenzoic acid, and combinations thereof, wherein at least part of the catheter is in direct contact with the aqueous liquid medium.

The invention discloses a preparation method of 1-(2-chlorphenyl)-2-(2-tetrazolyl) ethanone, which comprises the following steps: (1) under the action of an ether solvent and a strong base, enabling methyl 2-chlorobenzoate to react with trimethylsilanized diazomethane to generate 1-(2-chlorphenyl)-2-(2-tetrazolyl-trimethylsilane) ethanone; and (2) removing a TMS group from the 1-(2-chlorphenyl)-2-(2-tetrazolyl-trimethylsilane) ethanone, and then carrying out post-treatment to obtain the 1-(2-chlorphenyl)-2-(2-tetrazolyl) ethanone. According to the synthesis method, by-product isomers are reduced, the selectivity of 2-tetrazole is improved, and the total yield is further improved.