Application of pulvis fellis suis-combined type cholic acid in preparing drug for treating bronchial asthma

A combination of pig bile powder and combination technology, which can be used in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems that have not been reported, and achieve the effect of regulating immune response and blocking damage

Inactive Publication Date: 2017-02-15
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As far as the inventor knows, the application of porcine bile powder-bound total cholic acid and taurohyodeoxycholic acid in the preparation of drugs for the treatment of bronchial asthma has not been reported yet.

Method used

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  • Application of pulvis fellis suis-combined type cholic acid in preparing drug for treating bronchial asthma
  • Application of pulvis fellis suis-combined type cholic acid in preparing drug for treating bronchial asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Taking pig gall powder 100 g as an example, the preparation method of pig gall powder-bound total cholic acid and taurohyodeoxycholic acid is as follows:

[0022] 1. Preparation of pig bile powder-bound total bile acid

[0023] Take 100 g of pig gall powder medicinal material, add 10 times its volume of ethanol with a mass fraction of 95%, ultrasonically extract to completely dissolve pig gall powder, let it stand for 12-14 hours, filter, and recover the solvent to obtain a brown-black extract. Take 5 g of extract, add 10 g of 100-160 mesh column chromatography silica gel to mix the sample, evaporate the solvent, grind into 80 mesh fine powder, and dry the fine powder and neutral alumina at a mass ratio of 1:15 for chromatography In the column, elute with ethanol with a mass fraction of 95%, collect the eluate, and spot the sample on a silica gel G thin-layer plate with a capillary tube. The volume ratio of ethyl acetate to methanol, water, and glacial acetic acid is 10...

Embodiment 2

[0027] The medicinal preparation porcine bile powder-bound total bile acid is prepared into tablets, taking the production of 1000 tablets as an example, the raw materials and auxiliary materials and their quality ratios are as follows:

[0028] Pork Gall Powder Bound Total Cholic Acid 50g

[0029] Dextrin 50g

[0030] Magnesium Stearate 2g

[0031] Add starch to 300g

[0032] Its preparation method is carried out according to the conventional method of pharmacy tablets, each tablet weighs 0.3 g, and each tablet contains 50 mg of porcine bile powder-bound total cholic acid.

[0033] The medicinal preparation taurohyodeoxycholic acid is prepared into tablets, taking the production of 1000 tablets as an example, the raw materials and auxiliary materials and their quality ratios are as follows:

[0034] Taurohyodeoxycholic Acid 10g

[0035] Dextrin 50g

[0036] Magnesium Stearate 2g

[0037] Add starch to 300g

[0038] Its preparation method is carried out according to the...

Embodiment 3

[0040] The medicinal preparation porcine bile powder-bound total bile acid is prepared into capsules, taking the production of 1000 capsules as an example, the raw materials and auxiliary materials and their quality ratios are as follows:

[0041] Pork Gall Powder Bound Total Cholic Acid 50g

[0042] Microcrystalline Cellulose 20g

[0043] Magnesium Stearate 1g

[0044] Add starch to 300g

[0045] Its preparation method is carried out according to the conventional method of pharmacy capsules, each capsule weighs 0.3g, and each capsule contains 50mg of pig bile powder-bound total cholic acid.

[0046] The medicinal preparation taurohyodeoxycholic acid is prepared into capsules, taking the production of 1000 capsules as an example, the raw materials and auxiliary materials and their quality ratios are as follows:

[0047] Taurohyodeoxycholic Acid 10g

[0048] Microcrystalline Cellulose 20g

[0049] Magnesium Stearate 1g

[0050] Add starch to 300g

[0051] Its preparation m...

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Abstract

The invention discloses the application of a pulvis fellis suis-combined type total cholic acid and taurohyodeoxycholic acid in preparing a drug for treating bronchial asthma. The result of the invention shows that, the pulvis fellis suis-combined type total cholic acid and taurohyodeoxycholic acid has an inhibiting effect on the increased content of immunoglobulin, interleukin 4 and interleukin 13 in a model mouse. Meanwhile, the pulvis fellis suis-combined type total cholic acid and taurohyodeoxycholic acid can inhibit the secretion of proinflammatory cytokine, regulate the immunoreaction and effectively prevent the damage of immunoreactivity to human bodies, so that the bronchial asthma can be treated. The prepared pulvis fellis suis-combined type total cholic acid and taurohyodeoxycholic acid is adopted as a raw material to prepare various types of common preparations, such as tablets, capsules, powders, pills, granules and the like.

Description

technical field [0001] The invention relates to the application of porcine bile powder-bound total cholic acid and taurohyodeoxycholic acid in the preparation of medicines for treating bronchial asthma. Background technique [0002] Bronchial asthma (asthma for short) is one of the common chronic respiratory diseases. It is a chronic airway inflammatory disease involving a variety of inflammatory cells and inflammatory mediators. This chronic inflammation leads to the development of airway hyperresponsiveness, usually with widespread and variable reversible airflow limitation, and causes recurrent episodes of wheezing, shortness of breath, chest tightness, or coughing, often at night and in the early morning. In recent years, due to changes in climate and environment, the incidence, prevalence and mortality of asthma have been increasing year by year. Asthma seriously affects the quality of life of patients and brings a heavy economic burden to patients, so the disease has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61P11/06A61K31/575
CPCA61K31/575A61K35/413A61K2300/00
Inventor 何姣王孜晔尹兵
Owner NORTHWEST UNIV(CN)
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