Methyl p-tolyl sulfone and preparation method

Abstract

The invention discloses methyl p-tolyl sulfone and a preparation method. Methyl p-tolyl sulfone is prepared from components of raw and auxiliary materials in parts by weight as follows: 200 parts of water, 29 parts of sodium carbonate, 33 parts of anhydrous sodium sulfite, 45 parts of paratoluensulfonyl chloride, 1 part of activated carbon, 3 parts of sodium hydroxide and 16 parts of chloromethane. The preparation method comprises steps as follows: a) water is added to a salt formation kettle in proportion, stirring is started, sodium carbonate, anhydrous sodium sulfite and paratoluensulfonyl chloride are added once in proportion after heating, and the materials naturally react after a manhole is tightly closed; b) steam is introduced, heating and thermal insulation are performed, and a paratoluensulfonyl chloride solution is prepared; c) activated carbon is added in proportion during stirring, hot filtration is performed during stirring, and the mixture is subjected to direct replacement and then enters a methylation reaction kettle; d) steam is introduced, heating is performed, a chloromethane pipeline valve is opened for a methylation reaction; a methylation reduction reaction is performed again after thermal insulation; e) sodium hydroxide is sucked once for a neutralization reaction; f) the mixture is transferred into a centrifugal machine to be spin-dried and then transferred into an oven to be dried.

Description

technical field [0001] The invention relates to p-thymphenyltoluene and a preparation method thereof, and belongs to the technical fields of medicine, veterinary medicine, pesticide, dyestuff, raw material intermediate and preparation. Background technique [0002] P-thymphenyltoluene is an important intermediate of new medicine, veterinary medicine, pesticide and dyestuff promoted by the state. Appearance white crystal, melting point 86°C-88°C, insoluble in water, soluble in common organic solvents. It is designated as the intermediate of the new broad-spectrum antibiotic thiamphenicol, and also the intermediate of fluprofen, mesotrione, and sulcotrione. In foreign countries, it is widely allowed to be used in immunosuppressive state antibiotics, as well as food and feed additives, etc., and the market demand is increasing year by year. [0003] At present, the domestic production of p-thiamphenicol toluene as raw materials for medicine, veterinary drugs and pesticides is...

AI Technical Summary

Problems solved by technology

To prepare p-thymphenyltoluene, because p-thymphenyltoluene is a highly toxic drug, which is extremely harmful to the body and the environment, so it is not suitable for manual operation; with the strict control of highly toxic drugs, the price is also gradually rising. Therefore, the original traditional three process preparation methods have been gradually replaced by new production processes; such as the Chinese invention patent application with the application number 2008101626197 and the name "production process of p-thiamphenyl toluene", the p-thiamphenyl toluene produced by it The toluene product yield is 65%-70%, and the content is 99%. Quality: light brown powdery crystal; its disadvantages are: low content, low yield, poor quality, high impurity content, large consumption of raw and auxiliary materials, energy consumption ( Electricity, steam) high, long production cycle

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