Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Circulation harmlessness treatment method of colistin fermentation bacterial residue

A harmless treatment, colistin technology, applied in the direction of microorganism-based methods, biochemical equipment and methods, fermentation, etc., can solve the problems of environmental pollution, high treatment costs, high incineration costs, etc., to reduce production costs, The effect of changing physical properties and simple process

Inactive Publication Date: 2017-02-22
HEBEI SHENGXUE DACHENG PHARMA
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2008, antibiotic residues were included in the "National Hazardous Waste List". According to regulations, they can only be disposed of by incineration and landfill. However, the related disposal costs are very high, which is unbearable for enterprises, and these disposal methods will also cause great harm to the environment. Pollution is not a long-term solution
[0005] Bacillus polymyxa is a Gram-positive bacterium belonging to the genus Paenibacillus. Compared with the fermentation residue of Streptomyces, its fermentation residue has higher viscosity, fluidity and moisture content, so the transportation cost of the residue High and transportation is extremely inconvenient, and the cost of incineration is also higher. The post-processing of fungus residue is a major problem that plagues the production of colistin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Circulation harmlessness treatment method of colistin fermentation bacterial residue
  • Circulation harmlessness treatment method of colistin fermentation bacterial residue
  • Circulation harmlessness treatment method of colistin fermentation bacterial residue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] a. 1 kg of fresh colistin wet fungus slag filtered by ceramic membrane in the extraction workshop, its water content is 77%, add 40g of bran, 40g of bran, and 50g of distiller's grain to the wet fungus slag, stir and mix evenly, after mixing Squeeze with plate and frame to obtain the premix of fungus residue.

[0036] The moisture content of the premix was determined to be 42%.

[0037] b. Carrying out the solid-state fermentation of the fungus residue premix in step a, the temperature of the fermentation process is controlled at 28-40° C., and the fermentation period is 158 hours to obtain a solid-state fermentation product.

[0038] No residue of colistin was found in the fermentation product.

[0039] c. The solid-state fermentation product of the fungus residue in step b is dried at 85-95° C., crushed, and passed through a 60-mesh sieve to obtain the fungus residue powder.

[0040] After testing, the protein content of the fungus residue powder is 38%, the fat con...

Embodiment 2

[0044] a. 1 kg of fresh colistin wet fungus residue filtered by ceramic membrane in the extraction workshop, and its moisture content is measured to be 73%. Add 30g of bran, 30g of bran and 40g of distiller's grains to the wet fungus residue, stir and mix evenly, after mixing Squeeze with plate and frame to obtain the premix of fungus residue.

[0045] The moisture content of the premix was determined to be 44%.

[0046] b. Carrying out the solid-state fermentation of the fungus residue premix in step a, the temperature of the fermentation process is controlled at 28-40° C., and the fermentation period is 171 hours to obtain a solid-state fermentation product.

[0047] No residue of colistin was found in the fermentation product.

[0048] c. The solid-state fermentation product of the fungus residue in step b is dried at 85-95° C., crushed, and passed through a 60-mesh sieve to obtain the fungus residue powder.

[0049] After testing, the protein content of the fungus residu...

Embodiment 3

[0053] a. 1 kg of fresh colistin wet fungus slag filtered by ceramic membrane in the extraction workshop, its water content is 75%, add 35g of bran, 35g of bran, and 45g of distiller's grain to the wet fungus slag, stir and mix evenly, after mixing Squeeze with plate and frame to obtain the premix of fungus residue.

[0054] The moisture content of the premix was determined to be 43%.

[0055]b. Carrying out the solid-state fermentation of the fungus residue premix in step a, the temperature of the fermentation process is controlled at 28-40° C., and the fermentation period is 169 hours to obtain a solid-state fermentation product.

[0056] No residue of colistin was found in the fermentation product.

[0057] c. Preparation of fungal residue powder: the solid-state fermentation product of fungal residue in step b is dried at 85-95° C., pulverized, and passed through a 60-mesh sieve to obtain fungal residue powder.

[0058] After testing, the protein content of the fungus re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a circulation harmlessness treatment method of colistin fermentation bacterial residue, and particularly relates to the field of antibiotic fermentation bacterial residue circulation utilization. The circulation harmlessness treatment method comprises: a, adding the mixture of an organic nitrogen source and an organic carbon source to colistin fermentation bacterial residue, uniformly mixing, and pressing to obtain a bacterial residue premix; b, carrying out solid-state fermentation on the bacterial residue premix in the step a; c, drying the bacterial residue solid-state fermentation product in the step b at a temperature of 85-95 DEG C, crushing, and screening with a 60 mesh sieve to obtain bacterial residue powder; and d, replacing 25-45% of bean meal powder in a colistin fermentation culture medium by using the bacterial residue powder obtained in the step c so as to recycle. According to the present invention, the circulation utilization of the colistin fermentation bacterial residue is achieved through the bacterial residue modification method, such that the partial raw material is saved, the difficult problem that the colistin residue is not easily treated is solved, and the advantages of simple and feasible process, low cost and no influence on the colistin fermentation effect and the like are provided.

Description

technical field [0001] The invention relates to the field of recycling antibiotic fermentation residues, in particular to a recycling and harmless treatment method for colistin fermentation residues. Background technique [0002] my country is a major producer of antibiotics, and the discharge of bacterial residues ranks first in the world. A large number of discarded antibiotic residues not only pollute the environment, but also become one of the important factors that seriously restrict the development of the antibiotic fermentation industry. Antibiotic residues have been widely used as animal protein feed and feed pharmaceutical additives since the 1950s, but the residual antibiotics will be enriched in animals, and enter milk and eggs through lactation and egg production, and further harm human beings. Produce toxicity and side effects, and cause the pathogenic bacteria in the human body to develop drug resistance. In February 2002, the Ministry of Agriculture, the Mini...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12P21/04C12R1/12
Inventor 徐珍
Owner HEBEI SHENGXUE DACHENG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com