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Measuring method for N4-desoxymequindox, 3-methyl-2-acetyl-quinoxaline and MQCA in seawater

A technology of monooxyacetylmethaquine and dioxyacetylmethaquine, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effect of fast speed, low cost, and promotion of healthy development

Inactive Publication Date: 2017-02-22
山东省海洋资源与环境研究院
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AI Technical Summary

Problems solved by technology

[0006] At present, the three residual markers need to be determined separately by three different methods, and there is no precedent for one sample to measure the three residual markers at once.

Method used

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  • Measuring method for N4-desoxymequindox, 3-methyl-2-acetyl-quinoxaline and MQCA in seawater

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Experimental program
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Embodiment Construction

[0010] A kind of assay method of desoxyacetylmethaquine, desoxyacetylmethaquine and MQCA in seawater, it is characterized in that:

[0011] a) Instruments and reagents:

[0012] Ultra-high performance liquid chromatography-tandem mass spectrometer (Quattro Premier XE, Waters, USA), ultrapure water instrument (Milli-Q Gradient, Millipore, France), high-speed centrifuge (TGL-10C, Shanghai Anting Scientific Instrument Factory), Ultrasonic cleaner (KQ-600E, Kunshan Ultrasonic Instrument Co., Ltd.), nitrogen blowing instrument (N-EVAP TM 112, Organomation Associates, USA), automatic solid-phase extraction apparatus (ASPEC XL4+, GILSON, France); methanol (chromatographically pure), acetonitrile (chromatographically pure), formic acid (excellent grade), hydrochloric acid (excellent grade), acetic acid Ethyl ester (chromatographically pure), formic acid (excellent grade), sodium acetate (excellent grade), solid phase extraction cartridge (MAX 60mg 3mL, Waters, USA); acetylmethaquine ...

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Abstract

The invention discloses a measuring method for N4-desoxymequindox, 3-methyl-2-acetyl-quinoxaline and MQCA (3-methylquinoxaline-2-carboxylic acid) in seawater. The organism drug residue index is indirectly reflected with the measuring method. The measuring method includes the steps of instrument and reagent selecting and mixing, sample extracting and purifying and specific chromatographic condition and mass spectrum selecting. Compared with the prior art, the organism drug residue index is indirectly reflected with the measuring method for the N4-desoxymequindox content, the 3-methyl-2-acetyl-quinoxaline content and the MQCA (3-methylquinoxaline-2-carboxylic acid) content in seawater, the measuring method has the advantages of being high in speed, low in cost and free of damage to bred marine products, rapid and accurate data supporting is provided for the antibiotic abuse condition in current breeding industries, and healthy development of the breeding industries is facilitated.

Description

technical field [0001] The invention relates to the technical field of mariculture, in particular to a method for determining desoxyacetylmethaquine, desdiooxyacetylmethaquine and MQCA (3-methylquinoxaline-2-carboxylic acid) in seawater. Background technique [0002] The modern aquaculture industry tends to be large-scale and intensive, and the use of antibiotics, vitamins, hormones, metal trace elements, etc. has become an indispensable part of ensuring the development of the marine aquaculture industry. Unfortunately, due to the lack of scientific knowledge and the drive of economic interests, the phenomenon of drug abuse in farming is widespread. The situation is particularly serious in our country. The direct consequence of the abuse of veterinary drugs is the residue of veterinary drugs in animal food, which will affect human health after ingestion. The potential harm of veterinary drug residues in animal food to humans has attracted more and more attention. Only the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884Y02A50/30
Inventor 徐英江任传博田秀慧韩典峰薛敬林张华威邹荣婕罗晶晶黄会李佳蔚
Owner 山东省海洋资源与环境研究院