Perilla leaf extract and application of perilla leaf extract composition to preparation of drugs or foods used for reducing blood uric acid

A perilla leaf extract and perilla leaf technology are applied in drug combinations, medical preparations containing active ingredients, food science, etc., and can solve the major side effects of drugs, clinical application limitations, and perilla extracts to reduce blood uric acid, etc. To achieve the effect of inhibiting the synthesis of uric acid in the body, promoting the excretion of uric acid in the body, and inhibiting the activity of xanthine oxidase

Inactive Publication Date: 2017-03-08
国药集团健康产业研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Although a variety of drugs for the treatment of hyperuricemia have been developed clinically, these drugs have relatively large side effects, and their clinical application is limited; new therapeutic drugs found from natural plants or Chinese medicinal materials have good development prospects. Invented in China Patent CN104162063 reports a traditional Chinese medicine compound preparation for the treatment of hyperuricemia and its preparation method, using natural

Method used

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  • Perilla leaf extract and application of perilla leaf extract composition to preparation of drugs or foods used for reducing blood uric acid
  • Perilla leaf extract and application of perilla leaf extract composition to preparation of drugs or foods used for reducing blood uric acid

Examples

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Embodiment 1

[0033] Preparation of Perilla Leaf Extract Capsules

[0034]Weigh 100 grams of perilla leaves, add 500ml of mineral water or deionized water, soak for 2 hours, heat and reflux for extraction for 2 hours, take out the extract; add 500ml of water and extract once again, combine the extracts, concentrate under reduced pressure to a slurry Add microcrystalline cellulose according to the ratio of 1:1, mix, dry, pulverize, add 1% stearic acid, pack hard capsules, obtain the perilla leaf extract capsule of embodiment 1.

Embodiment 2

[0036] Preparation of Perilla Leaf Extract Capsules

[0037] Weigh 50 grams of perilla leaves, add 1500ml of mineral water or deionized water, soak for 2 hours, heat and reflux for extraction for 2 hours, take out the extract; add 1500ml of water and extract once again, combine the extracts, concentrate under reduced pressure to a slurry thing; add microcrystalline cellulose according to the ratio of 1:1, mix, dry, pulverize, add 1% stearic acid, pack hard capsule, obtain the perilla leaf extract capsule of embodiment 2.

Embodiment 3

[0039] Preparation of Perilla Leaf Extract Tablets

[0040] Weigh 50 grams of perilla leaves, add 2500ml of mineral water or deionized water, soak for 2 hours, heat and reflux for extraction for 2 hours, take out the extract; add 2500ml of mineral water or deionized water to extract again, combine the extracts and concentrate under reduced pressure To the slurry, add microcrystalline cellulose according to the ratio of 1:1, mix, dry, pulverize, add disintegrant and other auxiliary materials, mix evenly, granulate, compress into tablets, and obtain the Perilla leaf extract of Example 3 tablet.

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Abstract

The invention relates to a traditional herbal medicine-perilla leaf and a novel application of a traditional Chinese medicine composition of the perilla leaf. Through a mechanism of inhibiting xanthine oxidase activity and a mechanism of promoting uric acid to be discharged from urine, the concentration of uric acid in the blood of a body is reduced and the purposes of reducing uric acid and treating gout are achieved, so that perilla leaf extract and a traditional Chinese medicine composition of the perilla leaf extract can be applied to the preparation of drugs or foods used for preventing and treating the disease such as hyperuricemia, gout or the like. The perilla leaf extract and other traditional herbal medicines in the composition can be subjected to heating extraction by using water or hydrous ethanol as a solvent, the extraction is performed for 1-3 times, medicine residues are removed, the solvent is removed by reduced pressure concentration, powder is obtained through spray drying or freeze drying, and auxiliary materials are added to prepare a traditional Chinese medicine preparation or a food, particularly, a dosage form such as capsules, tablets, oral solutions, solid beverages or the like.

Description

technical field [0001] This patent relates to a perilla leaf extract and its composition for reducing uric acid in the blood, especially for the prevention or treatment of clinical hyperuricemia or hyperuricemia population. Background technique [0002] Perilla (scientific name: Perilla frutescens), ancient name Eren, also known as Su, Baisu, Guiren ("Er Ya"), Erzi, Chisu, Red Su, Fragrant Su, Black Su, White Perilla, Green Su , wild sage, suma, sage, Tang basil, wrinkled leaf sage, chicken sage, stinky stinky stalk, big basil, false basil, water cohosh, wild huoma, deaf ear hemp, zizhu, Xing Pasha karma ( Tibetan), etc., is the only species under the genus Perilla in Lamiaceae, an annual herb. Perilla leaf is also called Su Ye. It has the functions of relieving exterior cold, promoting qi and harmonizing stomach. It is mainly used for cold, cough, fullness of chest and abdomen, nausea and vomiting. Therapeutic effect, has expelling cold and relieving exterior syndrome, cl...

Claims

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Application Information

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IPC IPC(8): A61K36/535A61K36/8994A61P19/06A23L33/00A23L2/39A61K36/899A61K36/489A61K36/488
Inventor 吴春珍文雯陈静袁淑清周斌刘英胡海峰
Owner 国药集团健康产业研究院有限公司
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