Preparation method of polyelectrolyte sponge wound dressing based on carboxymethyl chitosan

A carboxymethyl chitosan and polyelectrolyte technology, which is applied in the fields of medical science, absorbent pads, bandages, etc., can solve problems such as the inability of hemostatic drugs to meet the requirements, achieve good biocompatibility and biodegradability, and achieve liquid absorption. Powerful, fast-absorbing effect

Inactive Publication Date: 2017-03-08
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

[0008] The object of the present invention is to provide a kind of preparation method of the polyelectrolyte sponge wound dressing based on carboxymethyl chitosan, the obtained polyelectrolyte sponge wound d

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  • Preparation method of polyelectrolyte sponge wound dressing based on carboxymethyl chitosan

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[0028] In specific embodiment, the preparation method of the polyelectrolyte sponge wound dressing based on carboxymethyl chitosan of the present invention, at first appropriate amount of carboxymethyl chitosan and biocompatible anionic polyelectrolyte or amphoteric polyelectrolyte are dissolved in Deionized water is then poured into the mold. By reducing the pH value of the polyelectrolyte mixture aqueous solution, the amino group of the carboxymethyl chitosan molecule is protonated, and interacts with anionic polyelectrolyte or amphoteric polyelectrolyte to form a complex and gradually gels. The polyelectrolyte complex gel was freeze-dried to obtain a spongy wound dressing. The specific steps are:

[0029] 1) Prepare an aqueous polyelectrolyte mixture solution containing carboxymethyl chitosan and anionic polyelectrolyte or amphoteric polyelectrolyte. Anionic polyelectrolytes or amphoteric polyelectrolytes are biocompatible polyelectrolytes containing -COO - 、-SO 3- 、-O-...

Embodiment 1

[0035] 8 grams of carboxymethyl chitosan, 13 grams of sodium polyacrylate and 1 g of gluconolactone were dissolved in 1 liter of deionized water, and then injected into a 10 cm × 100 cm × 30 cm rectangular glass mold. After incubation at 50°C for 10 hours, the solution formed a gel. Gels were frozen at -18°C for 24 hours. After vacuum-drying for 60 hours under a vacuum degree of 5 Pa in a vacuum drying oven, a spongy carboxymethyl chitosan polyelectrolyte wound dressing was obtained. Such as figure 1 Shown, carboxymethyl chitosan polyelectrolyte sponge wound dressing photo, the wound dressing of the present embodiment shows excellent hemostatic function and moisture absorption and water retention performance, can effectively control the exudate that wound produces, provides moisture for dry type wound, Accelerates wound healing and is easy to remove from the wound. The measurement of coagulation index in vitro in this embodiment shows that the coagulation index in vitro is ...

Embodiment 2

[0037] 8 grams of carboxymethyl chitosan, 10 grams of hyaluronic acid and 1 g of gluconolactone were dissolved in 1 liter of deionized water, and then poured into a 10 cm × 100 cm × 30 cm rectangular glass mold. After incubation at 50°C for 10 hours, the solution formed a gel. Gels were frozen at -18°C for 24 hours. After vacuum-drying for 60 hours under a vacuum degree of 5 Pa in a vacuum drying oven, a spongy carboxymethyl chitosan polyelectrolyte wound dressing was obtained. The wound dressing of this example exhibits excellent hemostatic function and moisture absorption and water retention performance, can effectively control the exudate produced by the wound, provide moisture for dry wounds, accelerate the healing speed of the wound, and is easy to remove from the wound. The measurement of coagulation index in vitro in this embodiment shows that the coagulation index in vitro is <50%; the hemostatic effect test result of the rabbit ear artery bleeding model shows that th...

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Abstract

The invention belongs to the field of biomedical material preparation, and relates to a preparation method of a polyelectrolyte sponge wound dressing based on carboxymethyl chitosan. According to the preparation method, a proper amount of carboxymethyl chitosan and biocompatible anionic polyelectrolyte/amphoteric polyelectrolyte are dissolved in deionized water, and then the solution is injected into a mould. By reducing the pH value of the water solution of the polyelectrolyte mixture, the amino group of carboxymethyl chitosan molecules is protonated, thus the carboxymethyl chitosan will interact with anionic polyelectrolyte/amphoteric polyelectrolyte through Coulomb force to form compounds, and gelation happens gradually. The compound gel is freeze-dried to obtain a sponge like wound dressing. The obtained polyelectrolyte sponge wound dressing has an excellent hemostatic function, water-absorbing performance and moisturizing property, can effectively control the exudates generated by the wounds, provides water for the dry wounds, accelerates the healing speed of wounds, and can be easily removed from the wounds. At the same time, the preparation technology is simple and can be applied to industry easily.

Description

technical field [0001] The invention belongs to the field of preparation of biomedical materials, and relates to a preparation method of polyelectrolyte sponge wound dressing based on carboxymethyl chitosan. Background technique [0002] Modern medical theory proves that wound healing is a continuous dynamic process of cell-to-cell, cell-to-cell matrix, and soluble media interactions. The wound repair process is related to the interaction of local tissue nutrition, microenvironment, growth factor content, microcirculation, hypoxic conditions, infection and other factors, and medical dressings can play a key role. As a main theoretical basis of high-tech medical dressings, the "wet therapy" discovered by British scientists in 1962 believes that when the surface of the wound is maintained in a moist microenvironment, the migration of epithelial cells is significantly accelerated, and the healing speed of the wound is faster than that of wounds. Fast in dry conditions. [000...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/32A61L15/42
Inventor 赵岩张劲松
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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