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Preparation method for poly(glycidyl methacrylate) polymer microsphere

A technology of polymethacrylic acid and glycidyl ester, which is applied in the field of functional materials to achieve the effects of uniform appearance, low reaction temperature and simple reaction process

Inactive Publication Date: 2017-03-15
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above methods are not commonly used in the preparation of polymer microspheres, the technology of preparing high-performance polymer microspheres with uniform shape and controllable size is still a major difficulty and hot spot at present.

Method used

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  • Preparation method for poly(glycidyl methacrylate) polymer microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of PGMA microspheres with a particle size of 1.0 µm

[0032] (1) Add 90 mL of ethanol and 10 mL of distilled water into a four-neck flask, then add 0.5 g of PVP, and mix and stir until the PVP is completely dissolved.

[0033] (2) Dissolve 0.05 g of the initiator in 1 mL of glycidyl methacrylate, and quickly inject it into the mixed solution in step (1), protect it with nitrogen throughout the process, mix and stir for 0.5 h, and then raise the temperature to 70 oC , reacted for 12 h.

[0034] The initiator is a composite initiator composed of potassium sulfate and azobisisobutyronitrile, and the molar ratio of potassium sulfate and azobisisobutyronitrile is 1:1.

[0035] (3) The product of step (2) was separated by centrifugation, washed three times with distilled water, ethanol, and distilled water, and finally dried in a vacuum oven for 24 h to obtain PGMA microspheres.

[0036] Such as figure 1 As shown in (a), the PGMA microspheres prepared in this e...

Embodiment 2

[0038] Preparation of PGMA microspheres with a particle size of 1.5 µm

[0039] (1) Add 90 mL of ethanol and 10 mL of distilled water into a four-neck flask, then add 1.5 g of PVP, and mix and stir until the PVP is completely dissolved.

[0040] (2) Dissolve 0.1 g of the initiator in 3 mL of glycidyl methacrylate, and quickly inject it into the mixed solution in step (1), protect it with nitrogen throughout the process, mix and stir for 0.5 h, and then raise the temperature to 70 oC , Reaction 12h.

[0041] The initiator is a composite initiator composed of potassium sulfate and azobisisobutyronitrile, and the molar ratio of potassium sulfate and azobisisobutyronitrile is 1:1.

[0042] (3) The product of step (2) was separated by centrifugation, washed three times with distilled water, ethanol, and distilled water, and finally dried in a vacuum oven for 24 h to obtain PGMA microspheres.

[0043] Such as figure 1 As shown in (b), the PGMA microspheres prepared in this exampl...

Embodiment 3

[0045] Preparation of PGMA microspheres with a particle size of 1.8 µm

[0046] (1) Add 90 mL of ethanol and 10 mL of distilled water into a four-neck flask, then add 3.0 g of PVP, and mix and stir until the PVP is completely dissolved.

[0047] (2) Dissolve 0.2 g of the initiator in 6 mL of glycidyl methacrylate, and quickly inject it into the mixed solution in step (1), protect it with nitrogen throughout the process, mix and stir for 0.5 h, then raise the temperature to 70 oC , reacted for 12 h.

[0048] The initiator is a composite initiator composed of potassium sulfate and azobisisobutyronitrile, and the molar ratio of potassium sulfate and azobisisobutyronitrile is 1:1.

[0049] (3) The product of step (2) was separated by centrifugation, washed three times with distilled water, ethanol, and distilled water, and finally dried in a vacuum oven for 24 h to obtain PGMA microspheres.

[0050] Such as figure 1 As shown in (c), the PGMA microspheres prepared in this exampl...

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Abstract

The invention discloses a poly(glycidyl methacrylate) polymer microsphere, belonging to the technical field of functional materials. The monodisperse poly(glycidyl methacrylate) polymer microsphere with uniform morphology and a controllable size is prepared by using a precipitation polymerization method with KPS-AIBN as a composite initiator, PVP as a dispersing agent and a mixed solution of water and ethanol as a solvent through initiation of GMA polymerization under the protection of nitrogen. The preparation method is simple and has low reaction temperature; the prepared microsphere has uniform morphology and particle size and stable structure and can be stably stored in water and solvents like ethanol; the surface of the microsphere contains a great number of epoxy groups, which is beneficial for surface modification and further modification; and the microsphere has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a preparation method of polyglycidyl methacrylate polymer microspheres. Background technique [0002] Polymer microspheres refer to polymer aggregates whose diameter ranges from nanometers to micrometers and whose shape is spherical. On the one hand, polymer microspheres have the advantages of large specific surface area, strong surface adsorption performance, and designability of aggregate structure composition. At the same time, the particle size is controllable and the shape is diverse. It has broad application prospects in the fields of detection and separation, interaction with biomolecules, detection of cell activity, synthesis of polypeptide chemicals, and immobilization of antibodies or antigens. With the continuous development of polymer microsphere preparation technology, it has developed from traditional emulsion polymerization, suspension pol...

Claims

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Application Information

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IPC IPC(8): C08F120/32C08F2/06
CPCC08F120/32C08F2/06
Inventor 张其清王傲宋立岛游力军
Owner FUZHOU UNIV
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