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A compound probiotic for regulating blood sugar and preparation method thereof

A compound probiotic and blood sugar technology, which is applied in the direction of medical preparations containing active ingredients, bacteria, drug combinations, etc., can solve the problems of no ideal method, etc., and achieve the effect of simple process, wide source of raw materials, and easy operation of the process

Active Publication Date: 2018-06-29
张世敏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no ideal method for the treatment of this disease, so it is the dream of researchers to constantly find new ways of prevention and treatment, and they will continue to explore for this purpose

Method used

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  • A compound probiotic for regulating blood sugar and preparation method thereof
  • A compound probiotic for regulating blood sugar and preparation method thereof
  • A compound probiotic for regulating blood sugar and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A compound prebiotic (chewable tablet or capsule) for regulating blood sugar, which is made of the following raw materials in parts by weight:

[0041]

[0042]

[0043] The additive is composed of any one of milk essence, jujube essence, ethyl maltol, guar gum, and sucralose, or any mixture of two to five of them.

[0044] The Gordona terrae sq-5 (Gordona terrae sq-5) CCTCC NO: M2012390.

Embodiment 2

[0046] A preparation method of a compound prebiotic (chewable tablet or capsule) for regulating blood sugar, the steps are:

[0047] A, strain culture: slant seed culture medium Cha's medium, freeze-dried seeds Gordonia terrestris sq-5 (patent No.: ZL2013 1 0016059.5) was inoculated on the slant of eggplant bottle, 28 or 29 or 30 or 31 or Incubate at 32°C for 3 days. Check that there is no miscellaneous bacteria, the growth is robust and uniform, and transfer to the inoculation bottle with sterile water.

[0048] B. Seed tank cultivation: Transfer the seed from the inoculation bottle described in A to the seed tank, cultivate at 28 or 29 or 30 or 31 or 32°C, and ventilate at 1:0.6 or 0.7 or 0.8, add bubble enemy automatically, and cultivate for 30 Or 32 or 34 or 35h, take a sample for microscopic inspection, and reserve after passing the test.

[0049] C. Fermentation tank culture: inject the seed liquid of the seed tank in the above-mentioned B into the fermenter with an in...

Embodiment 3

[0055] The impact of Gordonia terrestris sq-5 whole cell powder on the immune function of mice, the steps are:

[0056] The experimental animals were 62 Kunming male mice with a body weight of 20±2g. They were randomly divided into four groups, 20 in the distilled water+feed group (CK), and 0.0001g, 0.001g, 0.01Gordonia terrestris powder were added to the feed respectively. g, 14 animals each, were fed continuously for 14 days. On the 15th day, spleen lymphocytes were transformed to induce the production of IL-2, TNF and thymus weight. The results are shown in Table 1 and Table 2.

[0057] Table 1 Effect of Gordonia terrestris sq-5 bacterial powder on transformation of splenic lymphocytes

[0058] group

Number of mice N

normal saline

conA-induced

CK

20

3800±437

11258±1713

0.0001

14

8343±402

18307±3143

0.001

14

11286±2317

24532±4315

0.01

14

12688±1302

29563±2811

[0059] The ratio of the thr...

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PUM

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Abstract

The invention discloses a complex probiotic for glucose regulation and a preparation method. The complex probiotic is composed of autochthonic gordonia powder, synanthrin, microcrystalline cellulose, xylitol, powdered milk, tartary buckwheat powder, oat powder, pumpkin powder, additives and citric acid. The preparation method comprises the steps that A, cultures are cultivated, specifically, the freeze-dried cultures, namely autochthonic gordonia sq-5, are inoculated into an eggplant-shaped bottle bevel surface, and then transferred into an inoculation bottle through sterile water; B, cultivation is conducted in a culture pot, specifically, the cultures in the inoculation bottle are transferred into the culture pot for cultivation; C, cultivation is conducted in a fermentation pot, specifically, culture liquid in the culture pot is injected into the fermentation pot, each thallus is in a single ball arm shape, the bacterial count is 108-1010 individuals / ml, and fermentation is stopped; D, the autochthonic gordonia powder is prepared, specifically, fermentation liquid is boiled, inactivated, concentrated and dried, thalluses are collected, and the autochthonic gordonia powder is obtained; and E, complex probiotic chewable tablets are prepared, specifically, the raw materials are blended and then subjected to wet granulating and tabletting. By adoption of the complex probiotic, toxin and fat can be effectively cleared away, the digestion function is enhanced, the insulin resistance is improved, and glucose and lipid are regulated.

Description

technical field [0001] The present invention relates to the fields of preventive medicine and microecology, and more specifically relates to a compound prebiotic (chewable tablet or capsule) for regulating blood sugar, and also relates to a preparation of a compound prebiotic (chewable tablet or capsule) for regulating blood sugar The method is suitable for regulating and stabilizing the normal blood sugar level of diabetic patients, and is also suitable for the prevention and adjuvant treatment of high-risk groups of diabetes. Background technique [0002] With the rapid development of the economy, people's pace of life is constantly accelerating, and people's diet structure has undergone great changes. Overnutrition and imbalanced proportions have led to a significant increase in the incidence of metabolic diseases, and diabetes is one of the most rapidly increasing incidences. A class of diseases. It is well known that diabetes is a disease that seriously threatens human...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K36/899A61P3/10A61P5/50A61P37/04A61K35/20A61K31/733A61K35/741
CPCA61K31/733A61K35/20A61K35/741A61K36/42A61K36/70A61K36/899A61K2300/00
Inventor 张素琴张世敏刘艳丽
Owner 张世敏