Skin disease medicine composition, preparation method and application thereof

A composition and skin disease technology, applied in the direction of drug combination, skin disease, pharmaceutical formula, etc., can solve the problems of long treatment time, poor curative effect, easy recurrence, etc., and achieve the effect of simple preparation method, good curative effect, and simple operation

Inactive Publication Date: 2017-04-26
贺敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the external medicines used by western medicine to treat skin diseases are anti-inflammatory and antibacterial, such as oxytetracycline ointment, or corticosteroid ointment, such as piyanping, dacryline, etc., which not only have poor curative effect, long treatment time, but also tend to relapse after stopping the medicine
Moreover, a large amount or long-term use of antibiotics is likely to cause drug resistance and flora imbalance; long-term use of corticosteroids is prone to various side effects such as skin roughness, atrophy, steroid dermatitis, and rebound

Method used

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  • Skin disease medicine composition, preparation method and application thereof
  • Skin disease medicine composition, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Formulating Dermatological Sprays

[0032] The formula is as follows:

[0033] 90% alcohol 50ml

[0034] Fluconazole sodium chloride injection (sodium chloride content 8.5g / L, fluconazole content 1.5g / L) 7ml

[0035] Dexamethasone sodium phosphate injection (1ml: 1mg) 4ml.

[0036] The above three solutions were mixed evenly, stirred at an ambient temperature of 15° C. for 10 min, and then left to stand at a room temperature of 25° C. The standing time is 12h. Afterwards, the mixed liquid medicine is obtained for spraying.

Embodiment 2

[0038] Formulating Dermatological Sprays

[0039] The formula is as follows:

[0040] 95% alcohol 50ml

[0041] Fluconazole sodium chloride injection (sodium chloride content 9.5g / L, fluconazole content 1.5g / L) 3ml

[0042] Dexamethasone sodium phosphate injection (1ml: 5mg) 0.5ml.

[0043] Mix the above three solutions evenly, stir for 10 min at an ambient temperature of 20°C, and then stand still at a room temperature of 25°C. The standing time is 24h. Afterwards, the mixed liquid medicine is obtained for spraying.

Embodiment 3

[0045] Formulating Dermatological Sprays

[0046] The formula is as follows:

[0047] 95% alcohol 50ml

[0048] Fluconazole sodium chloride injection (sodium chloride content 9g / L, fluconazole content 1g / L) 4ml

[0049] Dexamethasone sodium phosphate injection (1ml: 2mg) 1ml.

[0050] The above three solutions were mixed evenly, stirred for 7 minutes at an ambient temperature of 20°C, and then left to stand at a room temperature of 25°C. The standing time is 20h. Afterwards, the mixed liquid medicine is obtained for spraying.

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PUM

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Abstract

The invention provides a skin disease medicine composition. The composition is prepared from an alcohol-water solution with concentration exceeding 90%, fluconazole and sodium chloride injection and dexamethasone sodium phosphate injection in a volume ratio of 50:3-7:0.5-4. The chlorine content in the fluconazole and sodium chloride injection is 8.5-9.5g / L, and the content of the fluconazol is 1.5-2.5g / L. The type of the dexamethasone sodium phosphate injection is 1ml:1mg, 1ml:2mg or 1ml:5mg. A method and an application of the skin disease medicine composition are further provided. Preferably the diseases include mycosis ungualis, tinea of feet and hands, itching skin and pruritus of perineum.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for skin diseases and its preparation method and application. Background technique [0002] Tinea pedis and tinea unguium are caused by a variety of different fungal infections. Tinea pedis and onychomycosis are very difficult diseases to cure. At present, there are many western medicines and Chinese medicines for treating tinea manus and onychomycosis. However, some western medicines are highly irritating, easily cause skin allergies, and are volatile. The big deficiency of side effect; Some Chinese medicines have the defects of poor permeability and long medication time. Some medicines for external use can cure the symptoms but not the root cause and are easy to relapse. Some liquids for external use dry out shortly after being applied to the affected area, and the efficacy of the medicine can not be balanced and act on the affected area for a long time. ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61K31/4196A61K31/661A61K31/343A61K31/513A61K31/7048A61P17/00A61K33/26A61K9/12A61P31/02A61P31/10
CPCA61K31/045A61K9/12A61K31/343A61K31/4196A61K31/513A61K31/661A61K31/7048A61K33/26A61K2300/00
Inventor 张跃平
Owner 贺敏
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