Synthetic process for 2-hydrazinylpyridine derivative
A synthetic process, the technology of hydrazinopyridine, applied in the direction of organic chemistry, can solve the problems of low product yield, no safety protection, and many steps, so as to improve selectivity and reaction rate, ensure selectivity and efficiency, and react The effect of mild conditions
Active Publication Date: 2017-04-26
江苏富比亚化学品有限公司
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Abstract
The invention discloses a synthetic process for a 2-hydrazinylpyridine derivative. The process includes the steps that a pyridine halide A, hydrazine hydrate and a solvent I are mixed for a reaction; and after the reaction and aftertreatment, a reaction product, namely the 2-hydrazinylpyridine derivative P is obtained. According to the process, the pyridine halide A can be obtained through a hydrogen substitution reaction of a precursor compound B under the conditions of bases and catalysts. N,N-dimethylpropanolamine in the solvent I plays the role of an acid-binding agent to a certain extent, and the reaction is promoted to the product generating direction; and in the hydrogen substitution reaction, the mixed catalysts are combined with compounding use of the strong base and the weak base, so that the selectivity of the hydrogen substitution reaction is improved, and the reaction speed of the hydrogen substitution reaction is increased.
Application Domain
Organic chemistry
Technology Topic
SolventSubstitution reaction +6
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