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Oxygen bridge cycloalkene ether terpenoid and preparation method and application thereof

A technology of terpenoids and bridged iridoids, which is applied in the field of oxygen-containing bridged iridoids, can solve the problems of lack of effective treatment methods for neurodegenerative diseases and the like, and achieve the effect of clear drug efficacy

Active Publication Date: 2017-04-26
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is still no effective treatment for neurodegenerative diseases, and finding effective drugs for the treatment of neurodegenerative diseases is a challenge for the scientific community

Method used

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  • Oxygen bridge cycloalkene ether terpenoid and preparation method and application thereof
  • Oxygen bridge cycloalkene ether terpenoid and preparation method and application thereof
  • Oxygen bridge cycloalkene ether terpenoid and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1 Compound extraction and separation method of the present invention

[0042] 1. Experimental equipment and reagents

[0043] 1 experimental equipment

[0044] Youpu UPT series ultrapure water device (UPT-I-10T, Chengdu Ultrapure Technology Co., Ltd.), electronic balance (BS124S, Sartorius Scientific Instrument Co., Ltd.), rotary evaporator (R-201, Yarong Biochemical Instruments) Circulating water multi-purpose vacuum pump (SHB-III, Zhengzhou Great Wall Science and Technology Industry and Trade Co., Ltd.), superconducting nuclear magnetic resonance instrument (Bruker BioSpin GmbH400 and600, Bruker BioSpin Company), high performance liquid chromatography (LC-10AT, Japan Shimadzu Corporation) , chromatographic column (ZO RBAXSB-C18 reverse phase column, Waters Company). Clean bench (SW-CJ-2FD, Suzhou Antai Air Technology Co., Ltd.), phase contrast inverted microscope (AE2000, Motic), centrifuge (ALLEGER X-12, BECKMAN), enzyme-linked immunoassay instrument (va...

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Abstract

The invention provides oxygen bridge cycloalkene ether terpenoid. The oxygen bridge cycloalkene ether terpenoid is characterized in that the structural formula of the oxygen bridge cycloalkene ether terpenoid is as follows, wherein R1 is H or OH, R2 is -OH or OAc, R3 is CH2Cl, CH2OH or O-liv and R4 is -OMe or OEt. The invention furthermore provides application of the cycloalkene ether terpenoid. The cycloalkene ether terpenoid is used for resisting to cancer and neuroprotection and definite in medical effect and can be a lead compound candidate drug for cancer resistance and neuroprotection.

Description

technical field [0001] The invention relates to oxygen-containing bridged iridoid compounds and belongs to the field of medicines. Background technique [0002] Tumor is a disease that seriously endangers human life. Its mortality rate is second only to cardiovascular and cerebrovascular diseases, and its incidence is increasing year by year. Chemotherapy, as the main means of tumor treatment, has a good curative effect. However, it often causes side effects such as myelosuppression and low immune function, making it difficult for patients to adhere to treatment, and the drug resistance of chemotherapy drugs during treatment has become one of the difficult problems in current clinical treatment. Therefore, it is necessary to seek therapeutic methods and drugs with good curative effect and little side effects. Traditional Chinese medicine has the basis of thousands of years of human toxicity experiments, and has the advantages of a wide range of drug sources, low prices, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61K31/357A61P35/00A61P25/00
CPCC07D493/08
Inventor 谭玉柱张梅张海李鸿翔王茹静杨凡陈银李坤林撒勋皓
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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