75 results about "Oxygen bridge" patented technology

Electrical cable having at least one conducting element, at least one polyolefin-based insulating covering layer, in which said insulating covering layer has at least one voltage stabilizer, said voltage stabilizer being a benzophenone substituted with at least one group selected from alkyl, arylalkyl and alkylaryl wherein said group: a) is linked to a phenyl ring of the benzophenone directly or via an oxygen bridge (-O-); b) contains, optionally, one or more oxygen bridges (-O-); and c) is optionally linked to a phenyl ring of at least one or other benzophenone group, provided that when said at least one group is an alkyl, optionally substituted, the carbon atom of said alkyl which is directly linked to a phenyl ring of said benzophenone is tertiary. A polyolefin-based insulating composition having at least one voltage stabilizer as described above.

The invention provides a rubiaceae-type cyclopeptide taken as a novel Hedgehog signal channel inhibitor as well as a preparation method and an application of the rubiaceae-type cyclopeptide in preparation of a medicine for treating and preventing relevant cancers activated by the abnormity of Hedgehog signal channels. The rubiaceae-type cyclopeptide is prepared by the condensation of one D-alpha-alanine, one L-alpha-alanine, three substituted N-methyl-L-alpha-tyrosines and one L-alpha-amino acid of another type via peptide bonds, wherein six amino acids are condensed into an eighteen-membered rings; and benzene rings between two adjacent tyrosines are connected via an oxygen bridge so as to form a fourteen-membered ring.

A method is proposed for improving the adhesion between a diffusion barrier film and a metal film. Both the diffusion barrier film and the metal film can be deposited in either sequence onto a semiconductor substrate. A substrate comprising a first film, which is one of a diffusion barrier film or a metal film, with the first film being exposed at least at part of the surface area of the substrate, is exposed to an oxygen-containing reactant to create a surface termination of about one monolayer of oxygen-containing groups or oxygen atoms on the exposed parts of the first film. Then the second film, which is the other one of a diffusion barrier film and a metal film, is deposited onto the substrate. Furthermore, an oxygen bridge structure is proposed, the structure comprising a diffusion barrier film and a metal film having an interface with the diffusion barrier film, wherein the interface comprises a monolayer of oxygen atoms.

The invention discloses a synthesis method of 16α, 17α-epoxy-4-pregnene-3, 20-dione. The process steps are: 10.0 parts of oxygen bridge, 70-80 parts of n-heptane and 35-40 parts of Mix 6-7 parts of cyclohexanone, heat and stir with water; after cooling down, add aluminum isopropoxide catalyst, reflux vigorously for 4 hours, cool down; add 6-7 parts of 30% NaOH solution dropwise, reflux for 20 minutes, add 2 % NaOH solution 20-25 parts, reflux for 30min, and remove alkaline water; then add 1% NaOH solution 20-25 parts, distill until no oil drops, suction filter, wash, dry; then dissolve with absolute ethanol, Reflux, freezing, suction filtration, Dewas oxide. The consumption of solvent, oxidant and catalyst of the present invention is less, only needs twice alkali washing, has simplified technology, has reduced production cost, and the content of Wo Shi oxidation reactant can reach 98.2%, and productive rate is more than 80%; The use of toluene reduces environmental pollution.

Antimicrobial compounds, compositions and methods of treatment administering same, of 2-aryloxyphenol derivatives having a heterocyclic or polar functional substitution attached through a N—C or C—C bond at the position para or ortho relative to oxygen bridge on non-phenolic phenyl ring, as well as methods for their preparation and formation, wherein the compounds are generally of Formula 1 and Formula 2:

The invention belongs to the technical field of medicines, and particularly discloses an oxygen-bridge bicyclo-[2.2.1]-heptylene compound comprising N-hydroxy-N'-phenyloctanediamide (SAHA) or a like structure, wherein the oxygen-bridge bicyclo-[2.2.1]-heptylene compound has an activity of resisting breast cancer. 3-(4-hydroxy penyl)-4-octanedioic acid monoanilide-furan and a vinyl sulphonate derivative are taken as raw materials and are reacted without a solvent or a catalyst at the temperature of 90 DEG C for 3 hours to further prepare the oxygen-bridge bicyclo-[2.2.1]-heptylene compound comprising the octanedioic acid monoanilide, and then the compound is reacted with oxammonium hydrochloride to obtain the oxygen-bridge bicyclo-[2.2.1]-heptylene compound comprising the N-hydroxy-N'-phenyloctanediamide. The experiments in vitro show that the oxygen-bridge bicyclo-[2.2.1]-heptylene compound has a great inhibitory activity on an MCF-7 cell in comparison to an existing anti-breast-cancer medicine tamoxifen.

The invention belongs to the preparation technical field of chemical compounds and in particular relates to a luminous transition metal organic skeleton structure compound and a preparation method thereof; the structural formula of the compound is (Zn5 (mu3-OH) (BTC) 3 (phen) 4).5H2O, wherein the mu3 is oxygen bridge link; BTC is 1, 3, 5-trimesic acid (C9H6O6); the phen is 1, 10-o-phenanthroline (C12H8N2), the molecular formula of the crystal is C75 H52 N8 O24 Zn5, and the molecular weight thereof is 1776.1, the crystal belongs to a monoclinic system and a C2 / c space group, the cell parameter Beta = 91.05(2) degrees, and the unit cell volume Z=8, Dc=1.673g / cm3. In the invention, cheap and nontoxic zinc acetate or zinc chloride is used as reactants, organic matters-trimesic acid and o-phenanthroline are used as ligands, so as to obtain Zn-MOFs material with a three-dimensional metal organic skeleton structure, the preparation process and equipment are simple, the heat stability of the material is high, the temperature can reach more than 400 DEG C, and the luminous transition metal organic skeleton structure compound can be widely applied to fluorescence labeling objects of organic bodies.

The invention belongs to the technical field of medicine and discloses a preparation method of an oxygen bridge dicycloheptene compound containing a resveratrol group. One of a 3-(4-hydroxyphenyl)-4-(((E)-3, 5-dihydroxystyryl)phenyl)furan compound and a 3, 4-bis(4-hydroxy-phenyl)furan compound and one of a vinylsulfonate and a vinylsulfonate derivative as raw materials undergo a reaction without a catalyst at 90 DEG C for 8h to produce the oxygen bridge dicycloheptene compound containing a resveratrol group. The oxygen bridge dicycloheptene compound has an action method different from that of the existing anti-breast cancer drug tamoxifen. The oxygen bridge dicycloheptene compound can effectively inhibit growth of breast cancer cells MCF-7 and triple-negative breast cancer cells MDA-MB-231, has good anti-inflammatory activity and has an application prospect in breast cancer treatment.

The invention discloses a dithienyl ethylene-trinaphthalene diphenyl imide near-infrared-fluorescence molecular switch, and a compounding method and application thereof. Multiple dithienyl ethylene are conjugated with single trinaphthalene diphenyl imide through oxygen bridge bonds, so that the defect that switching of a fluorophore cannot be controlled completely by the single trinaphthalene diphenyl imide can be overcome, and fluorescence switching speed and quenching efficiency can be enhanced effectively. The efficient butterfly dithienyl ethylene-trinaphthalene diphenyl imide is created, wherein the dithienyl ethylene is photochromic units and used for controlling illuminating and quenching of near infrared fluorescence clusters, and the trinaphthalene diphenyl imide is a fluorescence cluster used for emitting 650-800nm near infrared fluorescence, so that the obvious defects, such as low light stability, high compounding complexity, low fluorescence quantum yield and slow photoresponse, of near infrared diarylethene fluorescent molecular switches in the prior art are overcome.

The invention belongs to technical field of medicines and specifically relates to an oxygen bridge bis-heptylene sulfonamide compound containing a suberic acid monoanilide group as well as a synthesizing method, application and an anti-breast cancer drug composition of the oxygen bridge bis-heptylene sulfonamide compound. The oxygen bridge bis-heptylene sulfonamide compound containing the suberic acid monoanilide group is prepared by one-step reaction of the following raw materials: 3-(4-hydroxyphenyl)-4-suberic acid monoanilino-furan and an ethenyl sulfonamide derivative at the temperature of 90 DEG C for 3 without a solvent or a catalyst. The oxygen bridge bis-heptylene sulfonamide compound is different from the existing anti-breast cancer drug tamoxifen in action modes and is an anti-breast cancer compound acting on an estrogen receptor and histone histone deacetylase dual target sites.

The invention discloses a preparation method of a double-perovskite ferroelectric (FET)-antiferromagnetic (AFM) compound molecule with an oxygen bridge. In the invention, a method for compounding an FET molecule with an AFM molecule with different physical properties is described. A chemically-synthesized AFF (Antiferromagnetism-ferroelectrics) material can form an ABO3 double-perovskite compound structure with an oxygen bridge Bafm-O-Bfet. A method for compounding BaTiO3 serving as an FET typical material with NdBaMnO3 serving as an AFM typical material is taken as an example in the invention.

The invention discloses an oxygen bridge bicyclo-[2.2.1]-heptene compound containing different functional side chain structures, as well as preparation and application thereof. The preparation comprises the following steps that furan derivatives which contain different functional side chain structures (2,3-glycol butyl, N,N-diethoxy ethylamino, 2-pyrrolidinyl ethyl, 2-piperidine ethyl and alkyl acid) and are synthesized from 3,4-bis(4-methyoxy-phenyl)furan reacts with vinyl sulfonamide derivatives at 90 DEG C for 12 hours in one step without solvent or catalyst to prepare the oxygen bridge bicyclo-[2.2.1]-heptene compound containing basic side chains and other functional side chain groups. In-vitro experiments indicate that, compared with an existing anti-breast cancer drug tamoxifen, thenovel sulfamide type oxygen bridge bicyclo-[2.2.1]-heptene compound has stronger inhibiting activity on MCF-7 cells, and has excellent protein degrading activity and equivalent degrading performance as that of existing drug fulvestrant.

The invention provides an application of rubiaceous cyclopeptide RA-V (1) as a Hippo-YAP signal pathway inhibitor, a preparation method of the rubiaceous cyclopeptide and an application of the rubiaceous cyclopeptide to preparation of drugs for treating and preventing YAP abnormal activation related cancers. The rubiaceous cyclopeptide provided by the invention is formed by condensation of peptide bonds of one alpha-D-alanine, one alpha-L-alanine, three substituted N-methyl-alpha-L-tyrosine and one alpha-L-amino acid of other types, and six amino acids are condensed to form an eighteen-membered ring, wherein a benzene ring between two vicinal tyrosines is connected through an oxygen bridge to form a fourteen-membered ring. Compared with the prior art, the preparation method provided by the invention can be used for rapidly separating and purifying the target compound RA-V (1) and has the advantages of high efficiency, strong purposiveness, few separation step, convenience in operation, good controllability and repeatability, recyclable solvent, low cost and suitability for industrial production.

The invention discloses an ethylene tetramer catalyst composition which is characterized by comprising an oxygen bridge-containing cyclohexane ligand compound, a transition metal compound and an activator, wherein the oxygen bridge-containing cyclohexane ligand compound is a compound of a formula I shown in the description, and in the formula, R is selected from hydrogen, alkyl, alkoxyl or halogen. When the catalyst composition disclosed by the invention is adopted for an ethylene tetramerization reaction, a 1-octylene product can be produced with high selectivity, and the selectivity of 1-octylene can be up to 74% or greater.

The invention provides a trinuclear rare earth complex based on a schiff base ligand as well as a solvent thermal preparation method and application of the trinuclear rare earth complex. Schiff base formed by 4-aminoantipyrine and aromatic aldehyde with one hydroxyl group respectively at an ortho-position and a meta-position is taken as the ligand; the schiff base ligand is enabled to react with rare earth metal ions for 48-72h in a closed way under the conditions of low temperature and a mixed organic solvent, and is then subjected to coordination in a closed high pressure environment, so that the trinuclear rare earth complex which is clear in structure and stable in properties can be formed; from the view of the structure of the complex, the two hydroxyl oxygen adjacent atoms, which are respectively positioned at the ortho-position and the meta-position of the aromatic aldehyde, not only participate in the coordination, but also form an oxygen bridge so as to link three rare earth metal ions, so that the stability of the complex is improved. The solvent thermal preparation method of the trinuclear rare earth complex is simple and easy to control and convenient in purification, can be used for rapidly obtaining complex crystal, and facilitates structural analysis and performance study; furthermore, antibacterial experiments prove that the trinuclear rare earth complex based on the schiff base ligand has candida species resistance, thus being applied to inhibition of candida species as a bacteriostatic agent.

An anti-tumor activated ferric complex and preparation method thereof relate to complex preparation technique field. Dipyridylmethyl amine and 2-chrolomethylpyridine are used as materials, and react under the temperature condition of 20-80 DEG C for 1-3hours in acetonitrile solution according to 1:1 molar ratio between dipyridylmethyl amine and 2-chrolomethylpyridine, to prepare tripyridylmethyl amine (ligand L), then the combined tripyridylmethyl amine (L) is mixed with ferric trichroride and sodium tetraphenylborate in methanol solution and the molar ratio of tripyridylmethyl amine: ferric trichroride: sodium tetraphenylborate is 1: 1: 1, and stirred under the condition of 20-60 DEG C for 0.5-2 hours, finally oxygen-bridged dinuclear Fe(III) complex is synthesized : [LFeClOFeClOL]BPh4. The novel Fe (III) complex synthesized by the invention has excellent inhibitory effect to liver cancer.

The invention discloses a resin-based immobilized rhodium-phosphine complex catalyst as well as a preparation method and an application of the catalyst. A resin polymer is taken as a carrier and modified with a phosphine ligand and bonded with a rhodium complex, and the immobilized rhodium-phosphine complex catalyst is synthesized. According to the catalyst, the rhodium-phosphine complex is immobilized on the surface of carrier resin through oxygen bridged bonds, accordingly, a rhodium-phosphine coordination catalytic active center with higher catalytic activity and selectivity is formed on the surface of the carrier, so that the catalyst has the characteristics of mild reaction condition, good selectivity, stable catalytic performance, easiness in separation, recyclability and the like and can be used for catalysis of a 1-octene hydroformylation reaction.

The poly metal acid salt compound has molecular formula as Na14[MoVI126MoV28O462H14(H2O)68]íñca.300H2O, belongs to orthorhombic crystal system with space group as Cmca and single cell parameters as aú¢50.6844(4)ú¼bú¢56.3056(1)(cú¢30.6337(1)ú¼Vú¢87422.9(8)(3)ú¼Zú¢4. This product uses elementary huge-wheel ring shape as basic unit and Oxygen Bridge to link into two-dimension layer structure of calandria form, which can be used in adsorption material or solid fuel cell.

The invention belongs to the technical field of preparation of chemical compounds, and particularly provides a novel MOF (metal-organic framework) structure compound and a preparation method thereof. The structural formula of the compound is [Fe3(mu3-O)(C21O6H11)2(C3N2H4)3], wherein mu3 represents oxygen bridging; C21O6H11 is [1,1'3'1'] terphenyl-4,5',4'-tricarboxylic acid; C3N2H4 is imidazole; a structural unit of the compound belongs to a trigonal system and a R3 space group, a molecular formula of the compound is Fe3C51H31O13N6, molecular weight is 1536.54, lattice parameters are as follows: a=27.696(5) angstrom, b=27.696 angstrom, c=72.829(13) angstrom, alpha=90 degrees, beta=90 degrees and gamma=120 degrees, crystal cell volume is 48382(20) angstrom<3>, and Z=18. Fe3 cluster (Fe3(mu3-O)(COOCH3)6) is prepared from sodium acetate, ferric nitrate and ferrous sulfate, the MOF structure compound is prepared from (Fe3(mu3-O)(COOCH3)6), [1,1'3'1'] terphenyl-4,5',4'-tricarboxylic acid and imidazole and has a three-dimensional microporous structure formed by metal organic coordination, and proton conductivity is high. The preparation technology and equipment are simple, and heat stability of the material is high.

The invention discloses conductive nano-paper. The conductive nano-paper is composed of the following components in parts by weight: 30-55 parts of a polymer, 10-18 parts of clay, 15-30 parts of graphene, 2-4 parts of a stabilizer, 1-3 parts of a surfactant, 50-70 parts of a conductive active substance, and 10-20 parts of nano cellulose. The conductive nano-paper utilizes natural resources, is friendly to ecological environment, and acquires high value-added economic benefits; oxygen-containing groups on the surface of the graphene form a large amount of hydrogen bonds or are dehydrated to form oxygen bridges in a drying carbonization process, combination of the polymer, the conductive active substance and the graphene is promoted, and then through an alternated deposition process, the polymer and the conductive active substance act as the role of fibers and play a role in improving the toughness of the graphene-containing nano-paper; and through reasonable design of the structure and composition of the conductive paper, the prepared conductive paper has good flexibility and good conductivity, and can be widely applied in flexible electronic products.

The invention relates to an analyzer producing the polylactic and the producing process of producing the polylactic adopting the analyzer , characterized in that it is composed by the composite containing the strontium and the aluminium namely the compound system of the bimetal o-oxo bridge alkoxylating compound and the benznene sulfonic acid; the mol content of the said bimetal o-oxo bridge alkoxylating compound is 40-90 percent; the process of producing the polylactic adopting the analyzer : (1)the lactide of the melting range of 92-108 degree is embedded in the reactor and chilled, heated up; (2) it is vacuumized to dewater fully on the N2 condition; (3) the definite proportion of the composite catalyst mixing agent of the Sr and aluminium are added and mixed equably; (4) the air of the reactor is displaced by the highly pure nitrogen gas in order to keep the positive pressure; (5) It is mixed and heated up and the reaction can be finished within 4-16 hours. Because of adopting the analyzer to the production, the puzzle of the high purify requirement of the gathering monocase lactide needed by the existing ring-opening polymerization; so the reaction time is shortened, the producing rate is improved and the producing cost is reduced.

The invention discloses a method for synthesizing 3beta-hydroxy-16alpha,17alpha-epoxy-5-pregnene-20-ketone, which comprises the following steps of: adding 348.8 weight parts of methanol into 7.0 weight parts of diene, and heating to the temperature of 40 DEG C with stirring; reducing the temperature to be between 26 and 27 DEG C, and adding 68.7 weight parts of 30 percent H2O2, 34.3 weight parts of 10 percent NaOH, 22.9 weight parts of 30 percent H2O2 and 11.4 weight parts of 10 percent NaOH slowly; controlling the temperature to be between 28 and 30 DEG C in the process of adding liquid, raising the temperature to be between 34 and 35 DEG C, keeping the temperature, reacting for 3 to 4 hours, and distilling under reduced pressure to obtain a white solid; and washing the white solid, performing suction filtration, leaching, and drying at the temperature of 105 DEG C to obtain a high-purity oxygen-bridged object. In the method, a synthetic process is short in time, oxygen-bridged reaction is complete, a melting point of the product is stabilized between 189.5 and 191.2 DEG C, the content of the product is 99.3 percent, and the yield of the product is between 98.5 and 99.1 percent. The method is suitable for industrial production.

The invention discloses oxygen-bridged bicyclo-[2.2. 1]-heptene compounds containing different covalent warhead structures and preparation and application thereof, and belongs to the technical field of targeted drugs. The structure of the compounds disclosed by the invention is shown as a general formula (I) or a general formula (II), and a furan derivative and a vinyl sulfonamide derivative or a vinyl sulfonate derivative containing different covalent warheads are subjected to Diels-Alder reaction to prepare the compounds disclosed by the invention. The compounds provided by the invention can be used for preparing anti-breast cancer medicines, medicines for degrading estrogen receptors and medicines for mutant estrogen receptors. Compared with the existing anti-breast cancer drug tamoxifen, the compounds provided by the invention have stronger inhibitory activity on MCF-7 cells and have the ability to down-regulate the level of an estrogen receptor, and the activity of the compounds on a mutant estrogen receptor is 5-10 times that of 4-hydroxytamoxifen.

The invention discloses an application of an eight-membered oxygen bridge heterocyclic compound as a synergist of a bee selective insecticide. The structure of the eight-membered oxygen bridge heterocyclic compound is as shown in a formula I, and the definition of each substituent group in the formula is as shown in the specification and claims. The eight-membered oxygen bridge heterocyclic compound as shown in the formula I can significantly increase the insecticidal effect of the insecticide, shows selectivity to bees, and does not increase the toxicity of the insecticide to bees.

The invention provides a method for producing oxygen bridge material, which comprises the following steps of pumping methanol in a retort, adding dehydropregnenolone, stirring and heating to completely dissolve the materials, and preparing and adding aqueous sodium hydroxide solution into a sodium silicate complexing agent during lowering temperature; 30-35 min later, dropwise adding hydrogen peroxide and stirring; 30-35 min later, dropwise adding water containing soda and controlling temperature and reacting for 30 min; about 60 min later, dropwise adding hydrogen peroxide and reacting for 30 min; 60-90 min later, dropwise adding water containing soda and controlling the temperature to be 28-30 DEG C during dropwise adding; raising the temperature to be 36-40 DEG C naturally after the dropwise adding, and reacting for 6 hours within the temperature range of 36-40 DEG C; and confirming the material is qualified if the content of hydrogen peroxide is detected to be within the range of 0.5-0.8 percent after the reaction. The temperature can be controlled during the processing of dropwise adding just by using an explosion-proof mat and a headspace exhaust plant without the need of the protection of nitrogen, thereby achieving safer reaction.

The invention relates to application of an eight-membered oxygen-bridge heterocyclic compound as a pesticide synergist. Specifically, the invention discloses a compound with a structural formula as shown in (1) which is described in the specification. The compound can substantially reduce the LD50 or LC50 of pesticides under the condition of a low concentration and exerts strong synergistic effect on prevention and treatment of a plurality of pests like rice hoppers, whiteflies, cotton aphids, America periplaneta and houseflies.

The invention relates to a fluorite mine flotation agent, in particular to a fluorite mine flotation collecting agent. The fluorite mine flotation collecting agent comprises, by weight, 10 parts to 30 parts of 4-oxygen-bridge palmitic acid, 30 parts to 60 parts of oleic acid sulfation soap, 10 parts to 35 parts of terpenic oil, and 5 parts to 15 parts of octaphenyl polyoxyethyiene. The fluorite mine flotation collecting agent is good in selectivity and collection capacity, the grade of fluorite mine can be obviously improved, the recovery rate of fluorite mine can be obviously increased, the fluorite mine flotation collecting agent is suitable for the beneficiation process of lean ore and refractory ore, flotation froth is stable in property, the fluorite mine flotation collecting agent is resistant to hard water and low temperature, good in water solubility and dispersity, and agent consumption is substantially reduced.

The present invention relates to compositions comprising an epoxy resin; a reagent selected from the group of cationic compounds or compounds which are capable to form cationic compounds or mixtures of those; at least one compound with two aromatic rings and at least one central cyclic oxygen bridged ring and the use of such compositions in adhesives, sealants and coatings.

A method of processing an optical fiber of the invention includes: a determination step of determining at least an ambient temperature of conditions of a diffusion treatment that causing an optical fiber to be subjected to an non-oxygen bridging atmosphere; an exposure step of exposing the optical fiber to a gas including an oxygen bridging element that is capable of processing the Non-Bridging Oxygen Hole Centers by being bonded to a non-bridging oxygen in the optical fiber, and causing the oxygen bridging element to infiltrate into the optical fiber; and a diffusion step of subsequently causing the optical fiber to be subjected to the non-oxygen bridging atmosphere in the exposure ambient temperature which is determined by the determination step and at which the optical fiber is subjected to the non-oxygen bridging atmosphere, and thereby diffusing the oxygen bridging element into the optical fiber.