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Traditional Chinese medicine composition containing honeysuckle stems and leaves for preventing and treating constipation, preparation method and application

A technology for treating constipation and composition, which is applied in the direction of drug combination, application, and pharmaceutical formulation, etc., which can solve problems such as inability to substantially solve clinical problems, loss of self-defecation function, intestinal dependence on drugs, etc., and achieve improved intestinal Physiological environment, safe and reliable effect, effect of promoting intestinal peristalsis

Inactive Publication Date: 2017-05-10
河北京阳生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional western medicine often uses laxatives, intestinal motility-promoting drugs, probiotics and other interventional drug treatments, but they cannot substantially solve clinical problems
The reason is that some elderly people with long-term constipation take laxatives to promote defecation all the year round, which makes the intestinal tract dependent on drugs, weakens or loses the function of defecation by itself, and the result will further aggravate constipation

Method used

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  • Traditional Chinese medicine composition containing honeysuckle stems and leaves for preventing and treating constipation, preparation method and application
  • Traditional Chinese medicine composition containing honeysuckle stems and leaves for preventing and treating constipation, preparation method and application
  • Traditional Chinese medicine composition containing honeysuckle stems and leaves for preventing and treating constipation, preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0019] As an embodiment of the present invention, the traditional Chinese medicine composition contains 100% fine powder of honeysuckle stem and leaf, and the particle diameter of the fine powder of honeysuckle stem and leaf is less than 0.85 mm; or contains 50-100% by weight of honeysuckle stem and leaf water extract The water extract of stems and leaves of honeysuckle contains crude drug>3g per gram.

[0020] As an embodiment of the present invention, the dosage forms of the traditional Chinese medicine composition include granules, tablets, capsules, pills, dripping pills, oral liquids, effervescent tablets, extracts, syrups, sustained release agents, and controlled release agents. and targeted agents.

[0021] As an embodiment of the present invention, the traditional Chinese medicine composition also includes additives, and the additives include excipients, lubricants, antioxidants, preservatives, coloring agents, and sweeteners; the excipients include lactose , white su...

example 1

[0034] Example 1 Analysis of Active Components of Honeysuckle Stem and Leaf

[0035] Analytical instruments and raw materials:

[0036] Constant temperature drying oven Germany Memmert type

[0037] Electronic balance Sartorius BP211D, precision one hundred thousandth

[0038] Grinder Hangzhou Xionghuo Technology Co., Ltd.

[0039] Ultrapure water meter Merck millipore company

[0040] Analytical HPLC Dionex Ultimate 3000 Series

[0041] Low resolution mass spectrometer Bruker amazon SL ion trap mass spectrometer

[0042] The analytical chromatographic column is Phenomenex Gemini 5μC18 110A (5μm, 250×4.6mm)

[0043] Honeysuckle stems and leaves are provided by Julu Jingding Murad Honeysuckle Industrial Park

[0044] The active components of honeysuckle stems and leaves were analyzed by HPLC-MS method.

[0045]The preparation of the test solution is to get 0.5g of honeysuckle powder, honeysuckle leaf powder, and honeysuckle stem powder respectively, accurately weighed, p...

example 2

[0052] The preparation of example 2 Chinese medicine composition of the present invention

[0053] The traditional Chinese medicine composition of the present invention can be in two forms of micropowder and extract.

[0054] 2.1 Preparation of honeysuckle stem and leaf powder

[0055] The stems and leaves obtained when pruning honeysuckle plants in season are used as raw materials, washed, dried, and mechanically crushed into powder, the particle diameter of which is less than 0.85 mm (20 mesh), to obtain the fine powder of honeysuckle stems and leaves of the present invention.

[0056] It is also possible to add pharmaceutical excipients to the mechanically pulverized powder, and prepare it into dosage forms such as granules, tablets, capsules, or pills for clinical use.

[0057] 2.2 Preparation of honeysuckle stem and leaf water extract

[0058] The stems and leaves obtained when pruning honeysuckle plants in season are used as raw materials and prepared according to the ...

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating constipation. The raw materials of the traditional Chinese medicine composition comprise honeysuckle stems and leaves. The traditional Chinese medicine composition can be used for preparing drug or health-care food which is clinically used for promoting peristalsis and preventing and treating constipation, , and is used for preventing, controlling and treating diseases such as intestinal obstruction caused by poor peristalsis and constipation and colonic ulcer and complications of the diseases. The traditional Chinese medicine composition is simple in preparation process, low in energy consumption, pollution-free, safe and convenient and easy to store, has definite effects, and is easy to produce industrially.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for effectively improving clinical symptoms of constipation, belonging to the technical field of medicine and health. Background technique [0002] Constipation is one of the most common gastrointestinal symptoms in the elderly. Constipation can cause abdominal discomfort, anorexia, fatigue and other symptoms. The main complication is fecal impaction. Long-term constipation can also easily cause intestinal obstruction, colon ulcer and other diseases, which seriously affect the Health and quality of life in older adults. The etiology of constipation is currently unclear. Epidemiological investigations have shown that the onset of constipation presents a certain family trend, and there may be genetic factors. At the same time, constipation is also related to various factors such as diet, physiological conditions, social factors, mental state, and physical diseases. Reduced physical act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61P1/10A23L33/10A23L33/105A61K127/00A61K135/00
CPCA61K36/355A23V2002/00A23V2200/32A23V2250/20
Inventor 陈振兴栗原博
Owner 河北京阳生物医药科技有限公司
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