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Process for preparing belladonna liquid extract by ultrasonic dynamic multi-stage countercurrent extraction

A belladonna flow extract and dynamic countercurrent technology are applied in the field of preparing the belladonna flow extract by using a tank assembly ultrasonic dynamic countercurrent method, which can solve the problem that oxalate impurities cannot be effectively removed, the percolation time is long, and it is not suitable for selection. and other problems, to achieve the effect of easy industrialization amplification, shortening extraction time, and improving biological activity.

Active Publication Date: 2017-05-10
CSPC JIANGXI GOLDEN LOTUS PHARMA CO LTD
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

⑤ It is not suitable for fresh and easy-to-swell medicinal materials and unorganized medicinal materials
These substances are decomposed at high temperature, so the low-temperature percolation method is more suitable for the extraction of such alkaloid components. However, considering the long percolation time and the inability to use water, the oxalic acid that affects the quality of belladonna extract Salt impurities cannot be effectively removed, which is another important reason for the improvement of the belladonna fluid extract preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take belladonna whole herb powder 3kg, put belladonna powder in 3 extraction tanks respectively, 1kg in each extraction tank. Add 15L of pure water to each extraction tank, heat them to 40°C, and keep for 1 hour; after that, drain the water under reduced pressure. Add 10L of petroleum ether to the three extraction tanks respectively, heat and reflux for 0.5 hour, reflux once, and recover petroleum ether under reduced pressure respectively. Add 10L of 85% ethanol to the three cans respectively, heat to 30°C, set the ultrasonic power to 200W, and perform the first ultrasonic extraction for half an hour. Add 8 and 9 liters of 85% ethanol for the second and third times respectively. The second and third cans are supplemented with 1 to 3 times the amount of solvent on the basis of the previous can of medicinal liquid; each can of medicinal materials is extracted 3 times in total, and each extraction time is For 0.5 hours, the ultrasonic power is 200W each time, and the ultr...

Embodiment 2

[0020] Weigh 3kg of belladonna whole herb powder, adopt a single tank to extract, put belladonna powder in the first extraction tank. Add 45L of pure water to each extraction tank, heat to 40°C respectively, and keep for 1 hour; after that, drain the water under reduced pressure. Then add 30L of petroleum ether, heat to reflux for 0.5 hour, reflux once, and recover petroleum ether under reduced pressure. Add 30L of 85% ethanol to the three tanks, heat to 30°C, set the ultrasonic power to 200W, and perform ultrasonic extraction three times, each time using 30L of 85% ethanol, each extraction time is 0.5 hours, and each ultrasonic power is 200W. Combine three extracts respectively in the concentration tank, carry out decompression concentration, be concentrated to no alcohol smell, get belladonna liquid extract 0.5kg, extractum clarity, alkaloid content is 0.21% in terms of hyoscyamine, alkaloid extraction rate 70%.

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Abstract

The invention discloses a new process for preparing a traditional Chinese medicine belladonna liquid extract. The belladonna liquid extract is a domestic widely-used plant intermediate and clinically mainly used for gastric acid duodenal ulcer, angina of gastrointestinal tract, kidney and gallbladder and the like and has functions of removing smooth muscle spasm, restraining glandular secretion and the like. Original medicinal materials of the belladonna liquid extract are belladonna herb, and the belladonna herb is whole herb of Atropa belladonna L. A current main preparation method of the belladonna liquid extract is a percolation method, and the percolation method is long in consuming time, more in solvent consumption and insufficient in effective component enrichment. The invention discloses a process for preparing the belladonna liquid extract by ultrasonic dynamic multi-stage countercurrent extraction based on the conditions. According to the process, effective plant components are sufficiently extracted by the aid of ultrasonic cavitation effect, the dynamic multi-stage countercurrent extraction saves energy, and organic solvents are circularly used, so that the belladonna liquid extract is rapidly and effectively prepared. According to the process, an ultrasonic method is used in a dynamic multi-stage countercurrent extraction system for the first time.

Description

technical field [0001] The invention relates to the field of extraction of effective components of traditional Chinese medicines, in particular to a new process for preparing belladonna liquid extract by adopting a tank assembly ultrasonic dynamic countercurrent method. Background technique [0002] The percolation method is a method in which the treated coarse powder of medicinal materials is placed in a percolator, and the solvent is continuously added from the upper part to collect the extracted components of the percolation liquid. According to the operation method, it can be divided into single percolation method, pressure percolation method, heavy percolation method and countercurrent percolation method. Its characteristics are: ①The solvent is from top to bottom, from thin to thick, constantly causing concentration differences. The percolation method is equivalent to countless immersions. It is a dynamic process that can be operated continuously and has high leaching...

Claims

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Application Information

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IPC IPC(8): A61K36/81B01D11/02B01J19/10
CPCA61K36/81A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/53B01D11/0265B01D2011/002
Inventor 黄丽莉陈金龙邓胜杨燕欢郜杰贺周扬
Owner CSPC JIANGXI GOLDEN LOTUS PHARMA CO LTD
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