Liquid bracket material for bone repair and preparation method thereof

Abstract

The invention discloses a liquid bracket material for bone repair and a preparation method thereof. The liquid bracket material is prepared from the following raw materials: calcium sulfate, calcium polyphosphate, calcium tantalate, strontium silicate, modified graphene, a polylactic acid-hydroxyacetic acid copolymer, palmitoyl pentapeptide, wollastonite, polyglycerol lactate, cactus seed oil, silk fibroin, acetic acid, urea, distilled water and glycerol. The liquid bracket material provided by the invention has a good mechanical property, the compressive strength of the liquid bracket material reaches 64.5-69.6MPa, and the degrading rate is moderate, and the compressive strength of the liquid bracket material which is degraded for 15 days and 30 days is still maintained a relatively high level, and meanwhile, the liquid bracket material is good in anti-washout property and has good biocompatibility, so that a healing effect of accelerating bone repair is facilitated.

Description

technical field [0001] The invention belongs to the technical field of biological application materials, and in particular relates to a liquid scaffold material for bone repair and a preparation method thereof. Background technique [0002] Calcium sulfate has good biocompatibility, degradability, bone conduction and certain osteoinductivity, and is one of the most widely used main scaffold materials in bone tissue engineering research. In vitro cell culture studies have confirmed that calcium sulfate has no toxic effect on osteoblasts, is conducive to the attachment of osteoblasts, can also stimulate the proliferation and differentiation of osteoblasts, and promote bone repair and healing. In addition, calcium sulfate also has good injectability, and can be used as a liquid scaffold for irregular bone defects, which can avoid pre-shaping in vitro, and is also conducive to the uniform distribution of cells or / and growth factors in it, which has a wide range of application pr...

AI Technical Summary

Problems solved by technology

However, the degradation rate of calcium sulfate is fast, and its mechanical strength is low, which cannot meet the performance requirements of clinical applications.

[0003] The current research on calcium sulfate scaffold materials mainly focuses on enhancing its mechanical strength and slowing down its degradation rate, but so far, no liquid scaffold materials with good comprehensive performance have been obtained for bone repair.