Liquid bracket material for bone repair and preparation method thereof

A scaffold material and bone repair technology, which is applied in the fields of pharmaceutical formulation, medical science, prosthesis, etc., can solve the problems of unsatisfactory performance requirements, lack of comprehensive performance liquid scaffold materials for bone repair, and low mechanical strength, so as to promote healing Good effect, good biocompatibility, good anti-collapse performance

Inactive Publication Date: 2017-05-10
苏州纳贝通环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation rate of calcium sulfate is fast, and its mechanical strength is low, which cannot meet the performance requirements of clinical applications.
[0003] The current research on calcium sulfate scaffold materials mainly focuses on enhancing its mechanical strength and slowing down its degradation rate, but so far, no liquid scaffold materials with good comprehensive performance have been obtained for bone repair.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A liquid scaffold material for bone repair, prepared from the following raw materials in parts by weight: 10 parts of calcium sulfate, 12 parts of calcium polyphosphate, 4 parts of calcium tantalate, 3-8 parts of strontium silicate, modified graphene 2 parts, 1 part of polylactic acid-glycolic acid copolymer, 1.6 parts of palmitoyl pentapeptide, 2 parts of wollastonite, 2 parts of polyglyceryl lactate, 1.2 parts of cactus seed oil, 1.6 parts of silk fibroin, 0.6 parts of acetic acid, 2.4 parts of urea, 70 parts of distilled water, 22 parts of glycerin.

[0020] The modified graphene is aminated graphene. The calcium tantalate is prepared from calcium phosphate, tantalum chloride, urea and sodium trimetaphosphate with a mass ratio of 3:1.8:14:4.2.

[0021] A preparation method of a liquid support material for bone repair, comprising the following steps:

[0022] Step 1. Ultrasonic disperse the modified graphene in 3 / 4 of the total weight of distilled water, then add ca...

Embodiment 2

[0026] A liquid scaffold material for bone repair, prepared from the following raw materials in parts by weight: 25 parts of calcium sulfate, 18 parts of calcium polyphosphate, 13 parts of calcium tantalate, 8 parts of strontium silicate, and 6 parts of modified graphene , 4.2 parts of polylactic acid-glycolic acid copolymer, 4.5 parts of palmitoyl pentapeptide, 6 parts of wollastonite, 5 parts of polyglyceryl lactate, 3 parts of cactus seed oil, 4.3 parts of silk fibroin, 3.5 parts of acetic acid, 5.6 parts of urea parts, 88 parts of distilled water, and 38 parts of glycerin.

[0027] The modified graphene is aminated graphene. The calcium tantalate is prepared from calcium phosphate, tantalum chloride, urea and sodium trimetaphosphate with a mass ratio of 3:1.8:14:4.2.

[0028] A preparation method of a liquid support material for bone repair, comprising the following steps:

[0029] Step 1. Ultrasonic disperse the modified graphene in 3 / 4 of the total weight of distilled ...

Embodiment 3

[0033] A liquid scaffold material for bone repair, prepared by the following raw materials in parts by weight: 12 parts of calcium sulfate, 14 parts of calcium polyphosphate, 6 parts of calcium tantalate, 3.5 parts of strontium silicate, 2.4 parts of modified graphene 1.6 parts of polylactic acid-glycolic acid copolymer, 1.8 parts of palmitoyl pentapeptide, 2.7 parts of wollastonite, 2.8 parts of polyglyceryl lactate, 1.6 parts of cactus seed oil, 1.9 parts of silk fibroin, 0.8 parts of acetic acid, urea 2.7 parts, 74 parts of distilled water, 26 parts of glycerin.

[0034] The modified graphene is Tween 60 modified graphene. The calcium tantalate is prepared from calcium phosphate, tantalum chloride, urea and sodium trimetaphosphate with a mass ratio of 3:1.8:14:4.2.

[0035] A preparation method of a liquid support material for bone repair, comprising the following steps:

[0036] Step 1. Ultrasonic disperse the modified graphene in 3 / 4 of the total weight of distilled wat...

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Abstract

The invention discloses a liquid bracket material for bone repair and a preparation method thereof. The liquid bracket material is prepared from the following raw materials: calcium sulfate, calcium polyphosphate, calcium tantalate, strontium silicate, modified graphene, a polylactic acid-hydroxyacetic acid copolymer, palmitoyl pentapeptide, wollastonite, polyglycerol lactate, cactus seed oil, silk fibroin, acetic acid, urea, distilled water and glycerol. The liquid bracket material provided by the invention has a good mechanical property, the compressive strength of the liquid bracket material reaches 64.5-69.6MPa, and the degrading rate is moderate, and the compressive strength of the liquid bracket material which is degraded for 15 days and 30 days is still maintained a relatively high level, and meanwhile, the liquid bracket material is good in anti-washout property and has good biocompatibility, so that a healing effect of accelerating bone repair is facilitated.

Description

technical field [0001] The invention belongs to the technical field of biological application materials, and in particular relates to a liquid scaffold material for bone repair and a preparation method thereof. Background technique [0002] Calcium sulfate has good biocompatibility, degradability, bone conduction and certain osteoinductivity, and is one of the most widely used main scaffold materials in bone tissue engineering research. In vitro cell culture studies have confirmed that calcium sulfate has no toxic effect on osteoblasts, is conducive to the attachment of osteoblasts, can also stimulate the proliferation and differentiation of osteoblasts, and promote bone repair and healing. In addition, calcium sulfate also has good injectability, and can be used as a liquid scaffold for irregular bone defects, which can avoid pre-shaping in vitro, and is also conducive to the uniform distribution of cells or / and growth factors in it, which has a wide range of application pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/36A61L27/22A61L27/18A61L27/12A61L27/08A61L27/02
CPCA61L27/025A61L27/08A61L27/12A61L27/18A61L27/227A61L27/36A61L27/50A61L27/58A61L2300/412A61L2400/06C08L67/04C08L71/02C08L89/00A61L2430/02
Inventor 潘明华
Owner 苏州纳贝通环境科技有限公司
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