A kind of phytosterol ester and its low-temperature preparation method

A technology for phytosterol ester and phytosterol, which is applied in the field of phytosterol ester and low-temperature preparation thereof, can solve problems such as singleness, and achieve the effects of mild conditions, high conversion rate and low boiling point

Active Publication Date: 2019-01-01
NINGBO DAHONGYING BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved by the present invention is to provide a low-temperature preparation method of phytosterol esters, to overcome the influence of too high reaction temperature on phytosterols in the chemical catalytic synthesis method (chemical method), and to overcome the problem of biocatalytic synthesis method (enzymatic method) during preparation. singleness problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Get raw material phytosterol 100g (total plant sterol content 95%), soybean fatty acid 70g, add solvent methylene chloride 300ml, dissolve raw material phytosterol, then add catalyst p-toluenesulfonic acid 1g, esterification reaction temperature is 42 ℃, react 6h, During the reaction, the solvent was evaporated at 42°C, condensed and then refluxed to remove water. After the reaction, 2g of calcium oxide was added to neutralize the catalyst and excess fatty acid, the insoluble solids were removed by filtration, and the solvent was evaporated to dryness in vacuo to obtain 163g of phytosterol esters. The phytosterol esters had a purity of 97.3% as measured by GC-MS.

Embodiment 2

[0046] Get raw material phytosterol 100g (total phytosterol content 90%), soybean fatty acid 70g, add solvent sherwood oil 800ml, dissolve raw material phytosterol, then add catalyst p-toluenesulfonic acid 1g, esterification reaction temperature is 30 ℃, react 10h, react During the process, the solvent was evaporated at 30°C, and after condensation, the water was removed and refluxed. After the reaction, 2g of calcium oxide was added to neutralize the catalyst and excess fatty acid, the insoluble solids were removed by filtration, and the solvent was evaporated to dryness in vacuo to obtain 164g of phytosterol esters. The phytosterol esters had a purity of 96.6% as measured by GC-MS.

Embodiment 3

[0048] Get raw material phytosterol 100g (total phytosterol content 90%), linoleic acid 70g, add solvent methylene chloride 500ml, dissolve raw material phytosterol, then add catalyst p-toluenesulfonic acid 0.1g, esterification reaction temperature is 42 ℃, reaction 15h, the solvent was evaporated at 42°C during the reaction, and the water was removed and refluxed after condensation. After the reaction, 2g of calcium oxide was added to neutralize the catalyst and excess fatty acid, the insoluble solids were removed by filtration, and the solvent was evaporated to dryness in vacuo to obtain 163g of phytosterol esters. The phytosterol esters had a purity of 96.7% as measured by GC-MS.

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Abstract

The invention discloses phytosterol esters and a low-temperature preparation method thereof; the low-temperature preparation method comprises the steps of (1) esterifying, to be specific, adding a solvent to dissolve phytosterol and fatty acid that act as raw materials, and adding a catalyst to esterify at 30-65 DEG C, wherein the solvent is evaporatively condensed and is then dehydrated and refluxed; (2) carrying out acid-alkali neutralization, to be specific, after esterifying in step (1), adding a neutralizing agent to neutralize the catalyst and the redundant fatty acid, removing insoluble solid by filtering, and vacuum-drying by distillation to obtain phytosterol esters. The phytosterol esters are prepared through low-temperature catalytic reaction, both efficient reaction time in chemical synthesis and mild reaction conditions in enzymatic preparation are provided, singleness in enzymatic preparation is overcome, energy consumption is reduced, and industrial production is facilitated. The purity of the phytosterol esters prepared herein is up to 95% and above.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a phytosterol ester and a low-temperature preparation method thereof. Background technique [0002] Phytosterols, also known as phytosterols, are steroidal compounds, a class of natural active substances with cyclopentane polyhydrophenanthrene as the skeleton (also known as steroid nucleus), widely present in various vegetable oils, nuts and plant seeds, It also exists in other plant foods and vegetables and fruits, and there are many kinds, mainly including β-sitosterol, stigmasterol, campesterol and brassicasterol, of which β-sitosterol has the highest content, accounting for about 50-90% of the total sterols , is the main component of oil unsaponifiable matter. [0003] Phytosterols are one of the top ten functional nutritional ingredients recommended by the International Society of Nutrition in the future. As a natural plant food additive, in the small intestine of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00C07J75/00
CPCC07J9/00C07J75/00
Inventor 王嘉磊肖翔章生陶高峰魏国华
Owner NINGBO DAHONGYING BIO ENG
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