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A kind of Qingganjiedu tablet and preparation method thereof

A technology for clearing liver, detoxification and ointment, which is applied in the directions of antiviral agents, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of low bioavailability, long disintegration time, low dissolution rate, etc. Simple process, improved dissolution and bioavailability, and low production cost

Active Publication Date: 2020-06-30
恒拓集团广西圣康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention not only has good moisture-proof effect of the tablet, but also overcomes the defects of poor solubility, long disintegration time limit, slow effect, low dissolution rate and low bioavailability of the tablet, and is convenient to use, convenient to carry and store, stable in quality, The advantages of simple preparation process and low production cost

Method used

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  • A kind of Qingganjiedu tablet and preparation method thereof
  • A kind of Qingganjiedu tablet and preparation method thereof
  • A kind of Qingganjiedu tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] A preparation method of Qinggan Jiedu tablet includes the following steps:

[0077] (1) Weigh the raw materials according to the following parts by weight: 300 parts of Schisandra, 300 parts of Polygonum cuspidatum, 300 parts of Phyllanthus vulgaris, 300 parts of Gynostemma pentaphyllum, 300 parts of Salvia miltiorrhiza, 200 parts of Ganoderma lucidum, 200 parts of Fotan, 200 parts of rhubarb, Bupleurum 200 parts, 200 parts of Liu Shenqu, 200 parts of licorice, 500 parts of starch, 150 parts of sucrose, 30 parts of β-cyclodextrin, 90 parts of sucrose fatty acid ester, 150 parts of insect wax, 80 parts of gelatin syrup, simethicone 5 Parts, 200 parts of magnesium stearate and 5000 parts of ethanol.

[0078] (2) Take Schisandra, Danshen and Bupleurum spp. ethanol ultrasonic extraction twice. The amount of ethanol added for the first time is 7 times the weight of the medicinal material, and the amount added for the second time is 6 times the weight of ethanol. The ultrasonic fr...

Embodiment 2

[0083] A preparation method of Qinggan Jiedu tablet includes the following steps:

[0084] (1) Weigh the raw materials according to the following parts by weight: 300 parts of Schisandra, 300 parts of Polygonum cuspidatum, 300 parts of Phyllanthus vulgaris, 300 parts of Gynostemma pentaphyllum, 300 parts of Salvia miltiorrhiza, 200 parts of Ganoderma lucidum, 200 parts of Fotan, 200 parts of Rhubarb, Bupleurum 200 parts, 200 parts of Liu Shenqu, 200 parts of licorice, 600 parts of starch, 100 parts of sucrose, 20 parts of β-cyclodextrin, 100 parts of sucrose fatty acid ester, 100 parts of insect wax, 50 parts of gelatin syrup, 10 parts of simethicone Parts, 300 parts of magnesium stearate and 6000 parts of ethanol.

[0085] (2) Take Schisandra, Danshen and Bupleurum spp. ethanol ultrasonic extraction twice. The amount of ethanol added for the first time is 7 times the weight of the medicinal material, and the amount added for the second time is 6 times the weight of ethanol. The ul...

Embodiment 3

[0090] A preparation method of Qinggan Jiedu tablet includes the following steps:

[0091] (1) Weigh the raw materials according to the following parts by weight: 300 parts of Schisandra, 300 parts of Polygonum cuspidatum, 300 parts of Phyllanthus vulgaris, 300 parts of Gynostemma pentaphyllum, 300 parts of Salvia miltiorrhiza, 200 parts of Ganoderma lucidum, 200 parts of Fotan, 200 parts of Rhubarb, Bupleurum 200 parts, 200 parts of Liu Shenqu, 200 parts of licorice, 550 parts of starch, 200 parts of sucrose, 40 parts of β-cyclodextrin, 90 parts of sucrose fatty acid ester, 200 parts of insect wax, 100 parts of gelatin syrup, simethicone 8 Parts, 250 parts of magnesium stearate and 550 parts of ethanol.

[0092] (2) Take Schisandra, Danshen and Bupleurum spp. ethanol ultrasonic extraction twice. The amount of ethanol added for the first time is 7 times the weight of the medicinal material, and the amount added for the second time is 6 times the weight of ethanol. The ultrasonic fr...

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Abstract

The invention discloses liver clearing and toxin removing tablets and a preparation method thereof. The liver clearing and toxin removing tablets are prepared from the following raw materials in parts by weight: 300 parts of schisandra chinensis, 300 parts of polygonum cuspidatum, 300 parts of phyllanthus urinaria, 300 parts of gynostemma pentaphylla, 300 parts of salvia miltiorrhiza, 200 parts of lucid ganoderma, 200 parts of polygonum chinense, 200 parts of rheum officinale, 200 parts of radix bupleuri, 200 parts of medicated leaven, 200 parts of liquorice, 500-600 parts of starch, 100-200 parts of sucrose, 20-40 parts of beta-cyclodextrin, 80-100 parts of sucrose fatty acid ester, 100-200 parts of insect wax, 50-100 parts of gelatin syrup, 5-10 parts of dimeticone, 200-300 parts of magnesium stearate and 5,000-6,000 parts of ethanol. The liver clearing and toxin removing tablets disclosed by the invention not only realize a damp-proof effect, but also can overcome the defects of tablets of poor solubility, long disintegration time, slow effect, low dissolution rate and low bioavailability and have the characteristics of convenience in carrying, using and storing, simple preparation technology, low cost and high stability.

Description

Technical field [0001] The invention belongs to the technical field of Chinese patent medicines, in particular to a Qinggan Jiedu tablet and a preparation method. Background technique [0002] Liver-clearing and detoxifying drugs have clearing away heat and detoxification, removing dampness and relieving jaundice, and are suitable for auxiliary treatment of hypochondriac pain, jaundice, abdominal distension, nausea, nausea and vomiting, yellow urine, yellow fur and other symptoms caused by hepatitis B. Existing liver-clearing and detoxifying drugs are mainly based on B-Gan Qingre Jiedu Capsules. B-Gan Qingre Jiedu Capsules have been clinically used in China for many years. From the perspective of clinical use, its clinical efficacy has been affirmed. However, the capsule dosage form has the disadvantages of narrow applicable population, low bioavailability, poor drug stability, and susceptibility to moisture. Therefore, in order to promote the diversified development of traditio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/40A61K9/36A61K47/36A61K47/40A61K47/26A61K47/44A61K47/34A61K36/79A61K36/708A61P1/16A61P31/20
CPCA61K9/2013A61K9/2018A61K9/2036A61K9/205A61K9/2059A61K9/2826A61K9/2873A61K36/00A61K36/074A61K36/233A61K36/424A61K36/47A61K36/484A61K36/537A61K36/57A61K36/704A61K36/708A61K36/79A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 苏军峰
Owner 恒拓集团广西圣康制药有限公司