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Bone repairing biological ceramic support material prepared on basis of dry laying-sintering technology and preparation method thereof

A technology of scaffold materials and bioceramics, which is applied in medical science, prosthesis, coating, etc., can solve the problems of excessive strength of dense bodies, stress shielding, etc., and achieve the effect of fast fusion speed, appropriate pore size, and easy ingrowth

Inactive Publication Date: 2017-05-31
HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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Problems solved by technology

However, the excessive strength of the dense body also brings about the problem of stress shielding.

Method used

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  • Bone repairing biological ceramic support material prepared on basis of dry laying-sintering technology and preparation method thereof
  • Bone repairing biological ceramic support material prepared on basis of dry laying-sintering technology and preparation method thereof
  • Bone repairing biological ceramic support material prepared on basis of dry laying-sintering technology and preparation method thereof

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Embodiment Construction

[0057] The following is the canine lumbar vertebral body HA / ZrO 2 The bioceramic scaffold material is used as an example to illustrate the present invention in detail.

[0058] 1.1 Pretreatment of model organic foam materials

[0059] Polyurethane is used as the foam model material, because the polyurethane material has a network interlayer, and the existence of the interlayer makes it difficult for the slurry to enter the interior of the foam model, which will cause plugging, uneven distribution of the slurry, and poor porosity of the sintered foam ceramics. and poor mechanical properties. Therefore, it is necessary to open the membrane first, so that the organic foam forms a three-dimensional network structure. In addition, the organic foam model has poor hydrophilicity and small wetting angle, so the slurry is not easy to adsorb. In order to improve the slurrying performance of the foam model material, pretreatment is required. Cut the organic polyurethane foam material...

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Abstract

The invention relates to a preparation method of a biological ceramic support material. A preparation method of a bone repairing biological ceramic support material prepared on the basis of a dry laying-sintering technology comprises the following steps: (1) carrying out pretreatment on a polyurethane foam model material; (2) sintering ZrO2 ceramic; and (3) carrying out HA gradient coating, and preparing a bone defect biological ceramic repairing material. The preparation method provided by the invention has the advantages that nano ZrO2 particles are added in HA to enhance compressive strength and toughness of the support material, so that one bone repairing ceramic support with high porosity, high compressive strength and strong toughness is provided for bone defect healing. The bone repairing biological ceramic support material is high in porosity and appropriate in pore size, not only is hydroxyapatite easily degraded and absorbed, but also bone tissues can grow inside easily, fusion speed is high, combination with host bones is firm, obvious foreign body reaction can not be produced, and biological compatibility is good, and the biological ceramic in the invention can be used for bone tissue damage repairing and also can be used for cell culture in vitro.

Description

technical field [0001] The invention relates to a preparation method of a bioceramic support material. Background technique [0002] At present, it has become very common to treat patients with bone defects clinically by transplanting artificial bone. No matter what material the artificial bone comes from, the key to its successful transplantation is whether there is normal new bone tissue ingrowth in the grafted bone after surgery. It is mainly reflected in: 1. Whether sufficient amount of new bone is produced at the bone graft; 2. Whether there is a firm combination between the grafted bone and the normal bone tissue. It is worth noting that most of the bone grafts in clinical practice can only play the role of bone replacement, and cannot allow new bone to grow well into the graft and make it integrate. This also means that there is a risk of wear and aging of the grafted bone in the patient's body. Moreover, the healing of fractures after large-segment bone grafting i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/10A61L27/32A61L27/56
Inventor 全仁夫王拓谢尚举
Owner HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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