Anal fistula patch or plug, as well as preparation method and application thereof

A technique for anal fistula and allogeneic body is applied in the field of tissue engineering of biomedical materials to achieve the effects of prolonging degradation and digestion, improving flexibility, good elasticity and toughness
CN106730008AActive Publication Date: 2017-05-31BEIJING JAYYALIFE BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING JAYYALIFE BIOTECH CO LTD
Publication Date
2017-05-31

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Abstract

The invention provides an anal fistula patch or plug, as well as a preparation method and application thereof. The anal fistula patch or the anal fistula plug is prepared from an acellular dermal matrix. The acellular dermal matrix is obtained by performing protein enzyme solution digestive treatment, surfactant-containing hypertonic saline acellular treatment, crosslinking treatment, DNA degradation treatment and amino acid nutritional treatment on allogenic skin. The invention further provides application of the anal fistula patch or the anal fistula plug to preparation of a biological material for treating anal fistula. The acellular dermal matrix derives from human skin tissue, special physicochemical and biochemical treatment is conducted, all the components which may cause immunologic rejection are removed, the fiber three-dimensional stent structure of the original tissue is retained integrally, new vessels and fibroblasts grow quickly after implanting, and a good clinical effect is achieved.
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Description

technical field

[0001] The invention belongs to the technical field of tissue engineering of biomedical materials, and in particular relates to an anal fistula patch or suppository, a preparation method and an application thereof. Background technique

[0002] Anal fistula is a chronic infective conduit connecting the perianal skin and the rectum / anal canal, and consists of three parts: the internal opening, the fistula, and the external opening. Most anal fistulas are primary anal fistulas, which arise from a nonspecific infection of the anal glands that develop after the formation of a perianal abscess. Anal fistula is clinically manifested as recurrent perianal infection, ulceration and pus, and perianal cancer may occur in patients who do not heal for a long time. Anal fistula is one of the common anorectal canal diseases. It can occur at any age, and it is more common in men aged 30-50, with a male:female ratio of 2:1. Sainio reports an annual incidence of 8.6 / 100,000...

Claims

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