Preparation device of polymer-coated nano drugs and preparation method thereof

Abstract

The invention discloses a preparation device of polymer-coated nano drugs and a preparation method thereof and relates to the preparation of the nano drugs. The preparation device of the polymer-coated nano drugs comprises a differentiating solvent bottle, a first peristaltic pump, a fiber filament bundle crystallizer, a drug dissolving bottle, a second peristaltic pump and a vacuum filtering system, wherein the fiber filament bundle crystallizer is provided with an outer tube and an inner tube; the inner tube is arranged inside the outer tube; the differentiating solvent bottle is connected with the inlet of the first peristaltic pump; the outlet of the first peristaltic pump is connected with the inlet of the inner tube of the fiber filament bundle crystallizer; the outlet of the inner tube of the fiber filament bundle crystallizer is sealed; the drug dissolving bottle is connected with the inlet of the second peristaltic pump; the outlet of the second peristaltic pump is connected with the inlet of the outer tube of the fiber filament bundle crystallizer; the outlet of the outer tube of the fiber filament bundle crystallizer is connected with the vacuum filtering system; the inner tube of the fiber filament bundle crystallizer is formed by hollow porous fiber filament bundles. The preparation method of the polymer-coated nano drugs comprises the following steps: firstly preparing a fiber filament bundle crystallizer, then preparing nano drugs and coating the nano drugs with coating polymer, and carrying out aftertreatment to obtain products.

Description

technical field [0001] The invention relates to the preparation of nano-medicine, in particular to a polymer-coated nano-medicine preparation device and a preparation method using a micron-scale hollow porous fiber bundle crystallizer. Background technique [0002] In recent years, with the continuous development of nanotechnology, the unique properties of nanomedicine preparations developed based on nanotechnology have gradually been understood by researchers, such as passive targeting and enhanced osmotic retention effects. However, the direct use of nano-drug crystals is difficult to be directly applied to actual treatment due to various reasons, and they are often recognized and engulfed by macrophages in the immune system before reaching the effective part of the human body and fail. The use of degradable polymers (such as PLGA, PEG, etc.) to coat nanoparticles with polymer nano-loaded particles has many advantages: such as improving drug effectiveness, controlling rele...

AI Technical Summary

Problems solved by technology

However, these coating methods have some problems

The O / W-based nanoemulsion method is prone to soft agglomeration in the solution due to the unique properties of nanoparticles (high specific surface energy, strong van der Waals force) during the preparation process, and the produced polymer coats multiple nanoparticles and The resulting hard agglomerates cannot be separated; supercritical CO 2 The large-scale production of drugs is limited due to the low solubility of polymers or drug particles; spray drying technology requires high energy consumption conditions such as high temperature, and has limitations on the size of prepared nanoparticles, making it difficult to prepare particles smaller than 10nm; and Most of the preparation methods at this stage are batch production (batch process), resulting in low production efficiency, and the quality of each batch is uneven, making it difficult to effectively control in practical applications

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