High-efficiency hemostatic sponge
A hemostatic sponge and high-efficiency technology, applied in the field of medical and sanitary materials, can solve the problems of poor toughness, no pain relief and antibacterial effect, etc., and achieve the effects of strong toughness, strengthening platelet aggregation, and promoting the coagulation process.
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Embodiment 1
[0021] A high-efficiency hemostatic sponge, made of the following ingredients in parts by weight: konjac powder 12, collagen 30, chitosan 20, hydrogel 3, Humulus ethanol extract 0.2;
[0022] Described chitosan is through pretreatment:
[0023] ①Dissolve chitosan in a lysine solution with a mass fraction of 2.5% at a mass ratio of 1:35 to obtain acidified chitosan;
[0024] ②Dissolve tartaric acid in water at a mass ratio of 1:40 to obtain a tartaric acid solution;
[0025] ③ Drop tartaric acid solution and cyclic adenosine monophosphate into the acidified chitosan at a mass ratio of 2:0.2:13, and react for 18-20 hours to obtain a mixture. The mixture is ultrasonically treated with a frequency of 30KHz for 10s, and then the mixture is filtered , to obtain the filtrate, and then place the filtrate under vacuum for drying.
[0026] The collagen is extracted from squid skin, specifically: the squid skin is first cross-linked with EDC, then placed in a refrigerator at 0°C for 2 ...
Embodiment 2
[0033] A high-efficiency hemostatic sponge, made of the following ingredients in parts by weight: konjac powder 15, collagen 35, chitosan 25, hydrogel 6, Humulus ethanol extract 0.4;
[0034] Described chitosan is through pretreatment:
[0035] ①Dissolve chitosan in a lysine solution with a mass fraction of 3.2% at a mass ratio of 1:35 to obtain acidified chitosan;
[0036] ②Dissolve tartaric acid in water at a mass ratio of 1:40 to obtain a tartaric acid solution;
[0037] ③ Drop tartaric acid solution and cyclic adenosine monophosphate into the acidified chitosan at a mass ratio of 2:0.2:13, and react for 18-20 hours to obtain a mixture. The mixture is ultrasonically treated with a frequency of 30KHz for 10s, and then the mixture is filtered , to obtain the filtrate, and then place the filtrate under vacuum for drying.
[0038] The collagen is extracted from squid skin, specifically: the squid skin is first cross-linked with EDC, then placed in a refrigerator at 0°C for 2 ...
Embodiment 3
[0045] A high-efficiency hemostatic sponge, made of the following ingredients in parts by weight: konjac powder 14, collagen 32, chitosan 22, hydrogel 5, Humulus ethanol extract 0.3;
[0046] Described chitosan is through pretreatment:
[0047] ①Dissolve chitosan in a lysine solution with a mass fraction of 2.8% at a mass ratio of 1:35 to obtain acidified chitosan;
[0048] ②Dissolve tartaric acid in water at a mass ratio of 1:40 to obtain a tartaric acid solution;
[0049] ③ Drop tartaric acid solution and cyclic adenosine monophosphate into the acidified chitosan at a mass ratio of 2:0.2:13, and react for 18-20 hours to obtain a mixture. The mixture is ultrasonically treated with a frequency of 30KHz for 10s, and then the mixture is filtered , to obtain the filtrate, and then place the filtrate under vacuum for drying.
[0050]The collagen is extracted from squid skin, specifically: the squid skin is first cross-linked with EDC, then placed in a refrigerator at 0°C for 2 h...
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