Injectable hydrogel, and preparation method

Abstract

The invention provides an injectable hydrogel, and a preparation method thereof. The injectable hydrogel is obtained via self-crosslinking reaction of arginine-modified chitosan with a structure represented by formula (I) with a cross-linking agent; the polymerization degree n of the arginine-modified chitosan is equal to or higher than 10, and is equal to or lower than 3200; the arginine substitution degree ranges from 0.1 to 80%; the cross-linking agent is oxidized dextran. Compared with the prior art, the injectable hydrogel possesses following advantages: the biocompatibility is high; in vivo in-suit formation, and in vivo degradation can be realized; it is beneficial for direct acting of drugs at diseased regions, and long lasting of drug effect; oxidized dextran is safe and notoxic as the cross-linking agent; environment pollution is reduced; the degradation products are amino acids and polysaccharides, and can be discharged out of human body via kidneys, so that the injectable hydrogel is harmless for human body.

Description

technical field [0001] The invention relates to the technical field of polysaccharide polymer materials, in particular to an injectable hydrogel and a preparation method thereof. Background technique [0002] Hydrogel material is a three-dimensional network structure formed by physical or chemical cross-linking. Hydrophilic residues combine with water molecules to connect water molecules inside the network, while hydrophobic residues swell with water. It has the advantages of high water content, strong water retention capacity, softness, certain viscoelasticity and shape, and good biocompatibility. Hydrogel materials have unique properties and are a new class of functional materials, which have become a research hotspot in the field of biomedical polymer materials. [0003] Injectable hydrogel exists in a solution state and can be mixed with drugs; when implanted in a solution state by injection, it can rapidly undergo a sol-gel phase transition and form a gel in situ; at t...

AI Technical Summary

Problems solved by technology

Among them, biocompatible hydrogel-loaded protein drugs (Chemical Society Reviews, 2012, 41, 4860-4883) can be directly injected into the lesion to achieve sustained release of the drug, prolong the half-life of the drug, and effectively relieve the pain of the patient. But faced with the problem of cumbersome preparation process

With the deepening of scientific research, researchers have prepared block polymer-based hydrogels (Journal of Controlled Release, 2002, 85, 51-59), which are temperature-sensitive, cytocompatible Good, however, such block polymers tend not to be biodegradable and difficult to be absorbed and utilized by the body or eventually excreted from the body

At present, although some hydrogels based on synthetic polymers have been continuously developed, many of these gels are not ideal in biocompatibility, have potential risks of triggering immune reactions or inflammation, and their preparation process is complicated. To a certain extent, the further application of this type of hydrogel is limited

Images