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Sofosbuvir dispersible tablet and preparation method thereof

A technology of dispersible tablets and mass percentage, applied in the field of medicine, can solve the problems of large volume, inconvenient taking, difficult treatment and the like, and achieve the effects of simple preparation process, convenient taking and high bioavailability

Inactive Publication Date: 2017-06-23
PEKING UNIV FOUNDER GRP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets are large in size, or often need to use multiple tablets (grains) at a time, and need to be taken with water, which is inconvenient to take, especially for the elderly, young and patients with swallowing dysfunction.

Method used

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  • Sofosbuvir dispersible tablet and preparation method thereof
  • Sofosbuvir dispersible tablet and preparation method thereof
  • Sofosbuvir dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 sample: 1001 mg / tablet, 6 tablets;

Embodiment 2

[0045] Example 2 sample: 1002 mg / tablet, 6 tablets;

Embodiment 3

[0046] Example 3 sample: 1001 mg / tablet, 6 tablets;

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Abstract

The invention discloses a sofosbuvir dispersible tablet and a preparation method thereof. The dispersible tablet consists of the following components in percentage by mass: 30-70% of sofosbuvir, which serves as a raw material, and 40-90% of adjuvants, wherein the adjuvants include a filler, a disintegrating agent and a lubricating agent; and the preparation method comprises processes of weighing the raw material and the adjuvants, mixing the raw material and the adjuvants and tableting an obtained mixture. The dispersible tablet prepared by the invention can be completely disintegrated rapidly, so that a time to peak is shortened and drug absorbency; the dispersible tablet has the characteristics of being convenient to take, rapid in efficacy release, high in bioavailability and the like; and the preparation method is simple in process, easy for control, convenient to operate and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a Sofosbuvir dispersible tablet and a preparation method thereof. Background technique [0002] Hepatitis C virus hepatitis C or hepatitis C for short, is a kind of viral hepatitis caused by hepatitis C virus (Hepatitis C Virus, HCV) infection, a group of systemic infectious diseases mainly based on liver damage, its dosage form Symptoms are not obvious during the infection period and tend to become chronic. Hepatitis C can lead to chronic inflammation, necrosis and fibrosis of the liver, and some patients can develop liver cirrhosis or even hepatocellular carcinoma. The successful listing of sofosbuvir, when used in the treatment of specific genotypes of chronic hepatitis C, can eliminate the need for traditional injections of interferon (IFN), reduce adverse reactions and improve patient compliance, and are widely considered It is a breakthrough drug for chronic hepatitis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7072A61K47/38A61P31/14A61P1/16
CPCA61K9/2054A61K31/7072A61K47/38
Inventor 易崇勤王海超冀蕾
Owner PEKING UNIV FOUNDER GRP CO LTD
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