Polysaccharide hydrogel with double responses of pH and oxidation reduction as well as preparation method and application of polysaccharide hydrogel

A dual-response, hydrogel technology, applied in non-active ingredients medical formulations, aerosol delivery, liquid delivery, etc., can solve the uncertainty of synthetic polymer biocompatibility, limit the application of hydrogel, High economic cost, to achieve the effect of good biocompatibility, low price and extensive resources

Active Publication Date: 2017-06-27
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the stimuli-responsive hydrogels are mainly prepared based on synthetic polymers as raw materials. The preparation of synthetic polymers is affected by raw materials and preparation processes, and there are

Method used

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  • Polysaccharide hydrogel with double responses of pH and oxidation reduction as well as preparation method and application of polysaccharide hydrogel
  • Polysaccharide hydrogel with double responses of pH and oxidation reduction as well as preparation method and application of polysaccharide hydrogel
  • Polysaccharide hydrogel with double responses of pH and oxidation reduction as well as preparation method and application of polysaccharide hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1) Deionized water was used to prepare a 2 wt% acetoacetate wood pulp cellulose solution and a 10 wt% cystamine dihydrochloride solution. At room temperature, 0.1965g of 10wt% cystamine dihydrochloride solution was added to 2g of 2wt% cellulose acetoacetate solution, after mixing uniformly on a vortex shaker, let stand for 40min to form a gel ( figure 1 ).

Embodiment 2

[0031] 1) The preparation process and raw materials of multiple responsive polysaccharide hydrogels are the same as in Example 1

[0032] See figure 2 , the hydrogel ( figure 2 a), add high concentration hydrochloric acid solution (8M, 100μL) to the gel, and shake it on a vortex shaker, the gel will become a sol within 10min ( figure 2 b). Then, an equimolar amount of sodium hydroxide solution (8M, 100 μL) was added to the sol, and the sol transformed into a gel state again within 3 min ( figure 2 c), then add a high-concentration hydrochloric acid solution (8M, 100 μ L), and convert it into a sol ( figure 2 d).

Embodiment 3

[0034] 1) The preparation process and raw materials of multiple responsive polysaccharide hydrogels are the same as in Example 1

[0035] See image 3, the hydrogel in Example 1 ( image 3 a), add 100 μL, 10wt% DTT solution to the gel, shake and mix evenly on a vortex shaker to realize the transformation from gel to sol ( image 3 b), the required time is 30-60min, then add equimolar aqueous hydrogen peroxide solution (30wt%) in the gained sol, realize from sol to gel ( image 3 c), the required time is 10-30min.

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PUM

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Abstract

The invention relates to polysaccharide hydrogel with double responses of PH and oxidation reduction as well as a preparation method and application of the polysaccharide hydrogel. The polysaccharide hydrogel is prepared from the following raw material components: a cystamine dihydrochloride solution and a cellulose acetoacetate solution. The preparation method comprises the following steps: under the condition of room temperature, adding the cystamine dihydrochloride solution into the cellulose acetoacetate solution, oscillating, uniformly mixing and standing to obtain a finished product. The preparation method disclosed by the invention has the advantages of simple process, safe operation, mild reaction conditions and suitability for most polysaccharide derivatives; meanwhile, cellulose is used as a natural green material, and has the characteristics of abundant resources, good biocompatibility and biodegradability. With unique responsiveness and biocompatibility, the hydrogel has good application potential and a broad market prospect in the field of drug carrier release.

Description

technical field [0001] The invention belongs to the field of functional hydrogel and its preparation and application, in particular to a polysaccharide hydrogel with dual response to pH and redox and its preparation and application. Background technique [0002] Hydrogels are a class of polymers with a three-dimensional network structure that can absorb water and swell but are insoluble in water. It can absorb a large amount of water and swell significantly in water, and can continue to maintain its original structure without being dissolved after significant swelling. It is widely used in biological drug loading, cell culture, tissue engineering and other fields. Environmental stimulus-responsive hydrogels are a class of smart materials whose structure and properties can change with changes in the external environment. It can sense small changes in external stimuli, such as temperature, pH value, ionic strength, electric field, magnetic field, etc. Changes in structure or ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08B3/00C08B3/22C08L1/10A61K9/06A61K47/20A61K47/38
CPCA61K9/0002A61K9/06A61K47/20A61K47/38C08B3/00C08B3/22C08J3/075C08J2301/10
Inventor 隋晓锋荣立夺刘宏臣毛志平徐红张琳萍钟毅
Owner DONGHUA UNIV
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