68results about How to "The preparation method is simple and gentle" patented technology

The invention discloses a method for preparing a porous polymer micro needle by using a template method and an application thereof. The method comprises the following steps of: (1) dissolving a polymer and a template agent in a solvent to prepare a polymer solution; (2) filling the polymer solution into a micro needle mould; (3) removing the solvent in the obtained micro needle mould to obtain a solid micro needle; (4) removing the template agent in the obtained solid micro needle to obtain the porous polymer micro needle. By improving the overall process flow design of the preparation method,the method can solve the technical problems of a complex preparation process, harsh conditions, a complicated process, high price, difficult control of the pore structure and size, difficult large-scale production and application and the like of the porous polymer micro needle, the obtained porous polymer micro needle can be used for tissue fluid extraction and transdermal administration, such asskin tissue fluid and blood extraction and transdermal administration of proteins, polypeptides and small molecular drugs in cosmetic, hair growth, immunity, treatment and other applications.

The invention relates to a boron nitride / epoxy resin composite material. The boron nitride has a three-dimensional network structure, and the composite material comprises, by mass, 5-50% of boron nitride, 0.5-2% of sodium carboxymethylcellulose, 35-80% of epoxy resin, 10-30% of a curing agent and 0.1-10% of a catalyst. Boron nitride nanosheets in the composite material form a highly-ordered three-dimensional heat conduction network in a matrix, so the interface heat resistance is effectively reduced, and the heat conduction performance of the composite material is improved.

The invention relates to a method for treating osteoarthritis by stem cells and a composition. Particularly, the invention relates to a cell treatment composition for treating osteoarthritis and cartilage defects. The composition includes mesenchyma stem cells, hyaluronic acid or pharmaceutical salt, sodium chloride and water. The invention also relates to a method for preparing the composition. The cell treatment composition has the excellent properties.

The invention provides a multifunctional cigarette cracking capsule based on a liquid marble and a preparation method of the multifunctional cigarette cracking capsule, and belongs to the fields of colloid and interface science and micro-nano encapsulating. The multifunctional cigarette cracking capsule has a structure as shown below. The preparation method of the multifunctional cigarette cracking capsule comprises the following steps: I. dropwise adding liquid drops above a stabilizing agent which is hydrophobic powder, and preparing the liquid marble by virtue of a rolling dropping method; and II. immersing the liquid marble in a photo-curable coating which contains an initiating agent or spraying the photo-curable coating containing the initiating agent outside the liquid marble, and curing through ultraviolet radiation, so that a microcapsule is obtained. The multifunctional cigarette cracking capsule based on the liquid marble disclosed by the invention is simple and mild in preparation process, and is excellent in stability, water retention and moisture preserving properties, and disinfecting property; harmful ingredients in inhaled gas of a cigarette can be removed and cigarette taste can be enhanced; therefore, the multifunctional cigarette cracking capsule has broad application prospect.

The invention provides self-cured microspheres, which are prepared from a temperature-sensitive material with a lower critical soluble temperature, wherein the average particle size of the self-cured microspheres is in the range of 50nm to 100 microns, and the particle size distribution coefficient of the self-cured microspheres is smaller than 20%. The self-cured microspheres are prepared by thefollowing steps of: 1) providing a solution of the temperature-sensitive material added with bioactive substances or functional components as a dispersed phase; 2) providing emulsifying agent dissolved solvents which are dispersed and are insoluble with each other as continuous phases; 3) dispersing the dispersed phase in step 1) into the continuous phases in step 2) to obtain a pre-emulsion; 4) enabling the pre-emulsion in step 3) to pass through a microporous membrane for one time or a plurality of times under a pressure to obtain an emulsion; 5) heating the emulsion in step 4) to above thelower critical soluble temperature of the adopted temperature-sensitive material, so that liquid drops are cured to obtain the microspheres. The self-cured microspheres is suitable for serving as carriers of bioactive substances.

The invention provides a preparation method of modified phenolic resin base activated carbon. Oxidized graphene is added into phenolic resin to be uniformly dispersed, and the oxidized graphene is reduced into graphene in the follow-up activation and reduction treatment process, so that the activated carbon has the high conductivity, and a carbon material internal resistor is lowered; due to the phenolic resin foaming technology, the carbon material has the high porosity and can be easily mixed with base to be uniform, the application amount of the base is effectively lowered, and meanwhile the obtained activated carbon has the superhigh specific surface area; the phenolic resin is attached to an oxidized graphene sheet layer in the foaming curing process, generation of a mesoporous is promoted due to obstruction of oxidized graphene, and therefore the rate of the mesoporous of activated carbon is increased; the preparation method is simple, mild and suitable for large-scale industrial production.

The invention relates to a preparation method of an aerogel composite adsorbent for efficient removal of indoor formaldehyde. The method specifically includes the steps of: adding graphite oxide into an aqueous solution, and conducting uniform ultrasonic dispersion to obtain an graphene oxide aqueous solution; adding graphene carbon nanodots into the prepared graphene oxide aqueous solution, conducting uniform ultrasonic dispersion, then adding a reducing agent and ammonia water in order, and stirring the mixture fully to obtain a mixed solution; soaking a sponge into the mixed solution, performing sealing, then placing the product in constant temperature water bath to carry out water bath reaction; at the end of the water bath reaction, removing redundant solution, and carrying out freeze drying so as to obtain the adsorbent. Compared with the prior art, the preparation method provided by the invention is simple, mild, green and environment-friendly, and has no secondary pollution, the raw materials are easily available, and the prepared aerogel composite material has significantly improved formaldehyde adsorption performance uo to 22.81mg / g, and the longest penetration time is 7500min / g. Thus, the aerogel composite adsorbent has good application prospects.

The invention provides a method for preparing a titanium dioxide photocatalysis multi-layer film with an interface defect, which belongs to the technical field of titanium dioxide catalysts. On a low-temperature plasma film, a defect is introduced into a TiO2 double-layer film which is already prepared by a technique; by repeating the step for many times, the photocatalysis multi-layer film has the very good photoinduced hydrophilicity of the prepared TiO2 and very good photocatalysis activity and can carry out a photocatalysis reaction effectively. Furthermore, the multi-layer film has wide application range, low cost, convenient use and easy separation and recovery.

The invention relates to a boron nitride nanotube-nano-cellulose fiber composite material. The composite material is prepared from the following materials in percentage by mass: 5 to 40 percent of boron nitride nanotube, and 60 to 95 percent of nano-cellulose fiber. The invention further relates to a preparation method of the boron nitride nanotube-nano-cellulose fiber composite material. The preparation method comprises the following steps: mixing the boron nitride nanotube with a nano-cellulose fiber aqueous solution; performing ultrasonic treatment; performing solid-liquid separation to obtain the boron nitride nanotube-nano-cellulose fiber composite material. By adopting the composite material, the interface thermal resistance and phonon scattering action are reduced effectively, the heat-conducting property of the composite material is improved, and high dimension stability is achieved; the composite material is biodegradable. The preparation method is simple and mild, and can be applied to industrial production.

The invention relates to the field of biology and medicines, and especially relates to an adipose-derived stem cell preparation and a preparation method thereof. The adipose-derived stem cell preparation comprises adipose-derived stem cells, hyaluronic acid, alhumin and normal saline. The adipose-derived stem cells can maintain good survival rate and activity, and do not differentiate under the protection of hyaluronic acid, alhumin and normal saline in the adipose-derived stem cell preparation. The preparation method of the adipose-derived stem cell preparation provided by the invention can avoid damages of the adipose-derived stem cells, and improves the survival rate of the adipose-derived stem cells in the preparation. Experiments show that the adipose-derived stem cell preparation can maintain the survival rate of the adipose-derived stem cells above 99%, and allows the cells to have uniform size and shuttle-shaped form. After the adipose-derived stem cells are preserved at 0-4DEG C for 72h, the cells still maintain good form and have no volume enlargement or other abnormal phenomena, the survival rate still maintains above 95%, and the adipose-derived stem cells still maintain the characteristics of stem cells, and do not differentiate.

The invention provides solid perfume based on a liquid marble and a preparation method thereof and belongs to the field of colloid and interface science and cosmetics. The solid perfume is provided with a structure shown as follows. The method for preparing the solid perfume comprises the steps of taking hydrophobic powder as a stabilizing agent, adding liquid drops above the stabilizing agent dropwise, and preparing the liquid marble, namely the solid perfume, through a rolling dripping method. The preparation process of the long-acting slow-release solid perfume based on the liquid marble is simple and mild, the solid perfume has excellent stability, slow-release performance and gas permeability, can keep the air fresh effectively for a long time and have wide application prospects.

The invention provides a fluorescence chemical sensor for detecting 2,4,6-trinitrophenol and a preparation method of the fluorescence chemical reactor, belonging to the technical field of preparation and chemical analysis of functional high polymer materials. The fluorescence chemical sensor has a chemical structure shown in the specification. The preparation method of the fluorescence chemical sensor comprises the following steps: (1), in the presence of an acid-binding agent, performing condensation polymerization in an organic solvent by using phosphonitrilic chloride trimerl and curcumin to obtain a solution; (2), separating a solid product in the solution, washing and drying to obtain the fluorescence chemical sensor. The fluorescence chemical sensor based on ring-crosslinking type polyphosphazene, disclosed by the invention, is simple and mild in preparation process, has excellent thermal stability, chemical stability and fluorescence characteristics, can be used for realizing specific identification and detection of 2,4,6-trinitrophenol in a liquid phase, is high in sensibility, is suitable for the fields of trace explosive detection and environment monitoring, and is favorable for realizing industrial production.

The invention provides a preparation method of an Ag-Ag2O hetero-structure silver material, which aims at solving the problems of high cost and complex operation existing in the conventional hetero-structure silver material preparation method. The preparation method comprises the following steps of: one. preparing a mixed solution; two. preparing a silver nitrate solution; three. preparing silver nanoparticles; four. preparing a nanoparticle dispersion liquid; five. preparing a silver nanoparticle substrate; and six. oxidizing, thus obtaining the Ag-Ag2O hetero-structure silver material. The Ag-Ag2O hetero-structure silver material prepared by the method has good ball-like morphology and can be applied to the field of catalysis, photoelectricity and the like. The Ag-Ag2O hetero-structure silver material prepared by the method has the diameter of about 20mm and good dispersity and is uniform in distribution. The preparation method disclosed by the invention has the advantages of being mild and simple, easy to operate and environment-friendly and the like and having low requirements on experimental conditions. The method can be used for preparing the Ag-Ag2O hetero-structure silver material.

The invention relates to a tumor antigen loaded polydopamine nanoparticle, and a preparation method and an application thereof. The tumor antigen loaded polydopamine nanoparticle is prepared by covalently connecting a tumor antigen to the surface of a polydopamine nanoparticle through Michael addition and Schiff base reaction, wherein the tumor antigen comprises, but is not limited to, one or moreselected from the group consisting of a specific tumor antigen peptide fragment, a tumor cell lysate, a specific tumor antigen DNA fragment and an adjuvant CpG. The tumor antigen loaded polydopaminenanoparticle prepared by using the method provided by the invention has good biocompatibility, can effectively activate in-vivo anti-tumor immunity, significantly inhibits the growth of tumor cells, can improve the tumor immunosuppressive microenvironment, further enhances the anti-tumor activity of the human body, can be used for immune treatment of tumors, and is simple and pollution-free in preparation method.

The invention discloses a method for preparing a porous polymer microneedle based on a phase separation technology and application of the method. The method comprises the following steps that 1, a polymer is dissolved into a solvent A to obtain a polymer solution; 2, the polymer solution is put into a microneedle mould; 3, the microneedle mould is placed in a poor solvent B, so that phase separation of the polymer in the microneedle mould is facilitated; 4, the poor solvent B is removed, and then the porous polymer microneedle can be obtained. Through the simple and mild phase separation technology, the porous polymer microneedles can be prepared on a large scale, and therefore, the technical problems can be solved that the preparation process of the porous polymer microneedle is complicated, the conditions are harsh, the technology is tedious, the price is high, the pore structure, the size and the distribution are difficult to control, and it is difficult for large-scale production and application. The prepared porous polymer microneedle can be used for interstitial fluid extraction and transdermal drug delivery.

The invention relates to a method for a preparing porous titanium dioxide ball. The method comprises the following steps that 1), a titanium dioxide precursor is added into dispersion liquid of an m-aminophenol formaldehyde resin ball, after the mixture is stirred for several hours, centrifugal separation is conducted, and a compound of the m-aminophenol formaldehyde resin ball and the titanium dioxide precursor is obtained; 2), the obtained compound of the m-aminophenol formaldehyde resin ball and the titanium dioxide precursor in the step one is placed in an oven for standing for some time,and thermal treatment is conducted; 3) after thermal treatment, the compound of the m-aminophenol formaldehyde resin ball and the titanium dioxide precursor is placed in a nitrogen atmosphere for hightemperature carbonization and further roasted to remove carbon, and the porous titanium dioxide ball is obtained; compared with the prior art, the preparation method is simple and mild, the size of titanium dioxide holes can be adjusted by adjusting the concentration of the titanium dioxide precursor, the cost is low, the period is shorter, and the yield is higher.

The invention discloses a preparation method of quercetin-loaded nano-selenium. The quercetin-loaded nano-selenium comprises the following raw materials: a reducing agent, a reaction solution and a selenium source, wherein quercetin is used as the reducing agent, sodium selenite (Na2SeO3) is used as the selenium source, the reaction solution contains a stabilizer and a mixed solvent of methanol and water, and the stabilizer is gum arabic (As). The preparation method comprises the following specific steps: preparing nano selenium particles for loading quercetin, firstly preparing the reaction solution containing the stabilizer, adding quercetin and sodium selenite substance into the reaction solution, stirring and reacting for a period of time at room temperature, then adding a proper amount of tween 80, continuously stirring, removing methanol by rotary evaporation, and freeze-drying to obtain the quercetin-loaded nano-selenium. The invention further discloses application of the quercetin-loaded nano-selenium in treating Alzheimer's disease. The invention aims to provide a preparation method and application of a medicament for treating Alzheimer's disease.

The invention provides a gemcitabine-loaded polyethylene glycol (PEG) peptide dendrimer targeting drug-delivery system and a preparation method thereof to solve the problem of anti-cancer specificity of a dendrimer drug-delivery system. The drug-delivery system is characterized by being a conjugate of an anti-cancer drug gemcitabine, a targeted functional factor gly-phe-leu-gly (GFLG) and a PEG polypeptide dendrimer, and the gemcitabine is connected with the PEG peptide dendrimer through the GFLG to form a functional dendrimer. The same dose of drug achieves a significant antitumor effect when good biocompatibility is obtained.

The invention discloses a palladium-copper gold nanometer spinous oxygen reduction catalyst and a preparation method thereof. The preparation method comprises the following steps: respectively preparing a sodium tetrachloropalladate solution, a copper chloride solution and a chloroauric acid solution which have the concentration of 1 to 30 mM, a hydrochloric acid solution with the concentration of1 to 10 M and an ascorbic acid solution with the concentration of 0.01 to 0.5 M; mixing the sodium tetrachloropalladate solution, the copper chloride solution and the chloroauric acid solution of which the total volume is 4.5 mL, then adding 0.1 to 0.5 mL of the prepared hydrochloric acid solution, adding 0.1 to 0.5 g of potassium bromide and F127, and mixing uniformly; finally adding 1 to 10 mLof the ascorbic acid solution; after the solutions are fully mixed, placing the mixture in an oil bath pan, heating to 70 to 130 DEG C, reacting for 0.1 to 3 hours, and performing washing, centrifuging and drying to obtain the palladium-copper gold nanometer spinous electrocatalyst. The preparation method has the advantages of simple preparation process, and short reaction time. The material prepared at normal temperature and under normal pressure has superior electrochemical oxidation reduction performance.

The invention provides an epoxy resin / ordered boron nitride composite material and a preparation method thereof. The composite material comprises the following components by mass: 5%-60% of boron nitride; 30%-80% of epoxy resin; 5%-30% of a curing agent; and 0.1%-10% of a catalyst. Specifically, by adjusting the hot-pressing technological parameters, boron nitride microchips form in-plane directional arrangement in the epoxy resin matrix. The composite material has excellent in-plane orientation, thereby acquiring good heat conductivity coefficient; the preparation method of the epoxy resin / boron nitride composite material is simple and mild, and can be used for large-scale industrial production.

The invention aims to solve the problem about the anticancer specificity of a PEGylated dendrimer drug delivery system and provides a preparation method of a GFLG-based PEGylated peptide dendrimer drug delivery system. The preparation method is characterized in that the drug delivery system is a conjugate of the PEGylated peptide dendrimer, a targeted functionality factor GFLG and an anticancer therapeutic factor; GFLG is adopted to connect the therapeutic factor and the PEGylated peptide dendrimer to form a functionality dendrimer, so that excellent biocompatibility is obtained, and the remarkable anticancer curative effect is achieved by using medicine of the same or lower dosage.

The invention provides a multifunctional sun cream based on liquid beads and a preparation method of the multifunctional sun cream and belongs to the field of colloid and interface science and cosmetics. The multifunctional sun cream is of a structure shown as follows. The preparation method includes following steps: adding hydrophobic powder and a functional liquid into a stirrer according to a certain proportion; stirring at a high speed for a certain time to obtain fluffy liquid beads, namely the multifunctional sun cream. The multifunctional sun cream is simple and mild in preparation process, has excellent stability and water retaining, moisture preserving and sun screening characteristics, can effectively block ultraviolet rays and timely replenish moisture of skin and is conducive to industrialized production.

A boron-doped silver nano spongy catalyst for electrochemical ammonia synthesis is prepared by the following method: preparing an N,N-dimethylformamide (DMF) solution and aqueous solution of silver nitrate with a concentration of 0.01-1.0 M, and preparing a DMF solution and aqueous solution of sodium borohydride with a concentration of 0.01-1.0 M; adding 1.0 mL of the DMF solution and aqueous solution of silver nitrate with the concentration of 0.01-1.0 M into 5.0 mL of the DMF solution and aqueous solution of sodium borohydride with the concentration of 0.01-1.0 M, separately carrying out stirring for reacting for 1.5-2.5 hours under an ice-water bath condition and under a normal temperature condition, and carrying out washing, centrifuging and drying to obtain the boron-doped silver nanospongy catalyst. The invention also provides a preparation method of the boron-doped silver nano spongy for electrochemical ammonia synthesis. The preparation process is simple, the reaction time isshort, and the prepared material has excellent electrochemical nitrogen reduction performance at low temperature and normal pressure.

The invention discloses a palladium-ruthenium nano-thorn assembly catalyst and a preparation method thereof. Sodium tetrachloropalladate and ruthenium chloride solution of which the concentration is 1-30mM, hydrochloric acid solution of which the concentration is 1-10M and ascorbic acid solution of which the concentration is 0.01-0.5M are independently prepared; the sodium tetrachloropalladate andruthenium chloride solution of which the total volume is 3.0mL is independently taken for mixing, then, 0.1-0.5mL of prepared hydrochloric acid solution is added, and 0.1-0.5g of potassium bromide and F127 can be added to be evenly mixed; finally, 1-10mL of ascorbic acid solution is added; and after solution is fully mixed, the mixture is heated in an oil bath pan to 70-130DEG C to react for 0.1-3h, and washing, centrifugation and drying are carried out to obtain the palladium-ruthenium nano-thorn assembly catalyst. The preparation technology is simple, reaction time is short, and the prepared material has an excellent electrochemistry formic acid oxidation property at a normal temperature under normal pressure.

The invention discloses a preparation method of a double-targeting acid-sensitive prussian blue drug delivery system and an application thereof, which can effectively solve the problems of leukemia drug resistance and liver and spleen infiltration. According to the technical scheme, the preparation method comprises the following steps: firstly, adsorbing acid-sensitive polyethylene glycol-polyethyleneimine macromolecules on the surfaces of Prussian blue nanoparticles through electrostatic interaction and hydrogen-bond interaction; secondly, the CXCR4 antagonistic polypeptide (E5) and hyaluronic acid are connected with polyethyleneimine molecules on the surfaces of the prussian blue nanoparticles through chemical bonds; thirdly, daunorubicin is adsorbed to the surfaces of the prussian bluenanoparticles through hydrogen bond interaction. The preparation method is simple and mild, materials are safe and easy to obtain, good biocompatibility is achieved, a prepared carrier has the blood long-circulation capacity, the tumor cell double-targeting capacity, the lysosome escape capacity and the acid-sensitive drug release capacity, the mouse leukemia treatment effect can be effectively enhanced, and bone marrow homing and liver and spleen infiltration are inhibited.

The invention discloses a method for compositing a radial selenium nanotube at the room temperature, the method includes the following steps of 1) dissolving PVP in water, adding a selenium source, adding ascorbic acid while magnetic stirring, and performing centrifugal washing to obtain formless selenium nanoparticles; 2) dispersing the obtained formless selenium nanoparticles in absolute ethyl alcohol, and performing centrifugal washing to obtain the radial selenium nanotube, the method put forward for the first time has the advantages of simplicity, moderate reaction condition, high productyield, low cost of raw materials, easiness in raw material acquisition, safety, environment protection, dimensional uniformity of the prepared selenium nanotube, and wide application prospect in thenew energy and photovoltaic industry.

The invention relates to a gold-copper-boron porous network structure electrocatalyst. The gold-copper-boron porous network structure electrocatalyst is produced through a method which comprises the following steps: (1) producing N,N-dimethylformamide solutions, with concentrations of 1-40 mM, of copper chloride and chloroauric acid respectively; (2) taking the N,N-dimethylformamide solutions of the copper chloride and the chloroauric acid respectively according to the total volume of 4 mL for mixing, and then under conditions of room temperature and intense stirring, adding 20 mL of a fresh N,N-dimethylformamide solution, with a concentration of 1-40 mM, of sodium borohydride; and (3) after a reaction is carried out for 1-60 min, conducting washing, centrifugation and drying to obtain thegold-copper-boron porous network structure electrocatalyst. The production method of the gold-copper-boron porous network structure electrocatalyst is further provided. The production method is simple, the reaction time is short, the reaction conditions are mild, and the produced material has excellent performance of electrochemical ammonia synthesis through nitrogen reduction.

The invention discloses a rare earth Tb doped bismuth vanadate photocatalyst and a preparation method thereof. The preparation method comprises the following steps: dissolving bismuth nitrate pentahydrate in a nitric acid solution to obtain a solution A; dissolving ammonium metavanadate into a sodium hydroxide solution to obtain a solution B; slowly dropwise adding the solution A into the solutionB, and uniformly performing stirring to obtain a bismuth vanadate suspension; dropwise adding the terbium chloride solution into the bismuth vanadate suspension to obtain terbium-doped bismuth vanadate suspension, continuously performing stirring, adjusting the pH value to 6 by using a sodium hydroxide solution, carrying out water bath at 80-90 DEG C for at least 1h, performing cooling, carryingout suction filtration to obtain a precipitate, drying, performing calcining at 480-520 DEG C for at least 4h, performing cooling, and grinding theprecipitate into powder to obtain the rare earth Tb-doped bismuth vanadate photocatalyst. The photodegradation efficiency of the rare earth Tb doped bismuth vanadate photocatalyst reaches up to 99%, a liquid phase precipitation method is adopted, and the preparation method is simple and mild.

The invention discloses a high throughput antibacterial composite nanofiltration membrane and a preparation method thereof. The preparation method comprises the following steps: (1) adding branched polyethyleneimine and an acid binding agent into water to obtain a water phase, enabling a functional layer surface of an ultrafiltration membrane to be contacted with the water phase, and removing theexcess water phase on the surface of the membrane; (2) putting a monomer into an organic solvent to prepare an organic phase solution, enabling the surface, which is contacted with the water phase andis obtained in the step (1), of the membrane to be contacted with the organic phase solution for 30-300s, and removing the excess organic phase solution on the surface of the membrane; (3) placing the membrane, obtained in the step (2), at the temperature of 30-150 DEG C for 1-60min; washing the obtained membrane with deionized water to obtain the high throughput antibacterial composite nanofiltration membrane. The high throughput antibacterial composite nanofiltration membrane prepared by the method also has very high bacteriostatic rate while having high throughput. The preparation method adopts simple interfacial polymerization to directly prepare the high throughput antibacterial composite nanofiltration membrane, and is simple and convenient, mild in conditions and suitable for industrial production.

The invention discloses a preparation method of a calcium carbonate film layer on the surface of a biomedical degradable metal material, belonging to the technical field of biomedical coating material preparation. The preparation method comprises the following preparation steps: pretreating the surface of a medical metal material through waterproof abrasive paper; mixing calcium salt, carbonate, an additive and water to prepare a mixed solution, and adjusting the pH value of the mixed solution; and immersing the pretreated metal material into the prepared mixed solution, and keeping a constant temperature for a certain time to form a calcium carbonate film layer on the surface of the metal material. According to the invention, the calcium carbonate film layer prepared by using the inorganic magnesium salt and the organic molecular additive is controllable in morphology, uniform and compact, good in binding force with a metal material matrix, excellent in biocompatibility, biological activity and biodegradability, and capable of remarkably improving the corrosion resistance of the metal material; and meanwhile, the preparation method is simple, mild, green, environment-friendly and low in cost, and has the prospect of being applied to biomedical metal materials on a large scale.