Preparation method of starch microspheres with small particle sizes

Abstract

The invention discloses a preparation method of starch microspheres with small particle sizes. The preparation method comprises steps as follows: (1) preparation of a starch solution; (2) preparation of a polyvinylpyrrolidone solution; (3) forming of an aqueous two-phase emulsion through high-speed shearing and emulsification performed after the polyvinylpyrrolidone solution is added to the starch solution; (4) balling through retrogradation and solidification, separation and washing: the emulsified aqueous two-phase emulsion is put in an environment at the temperature of 4-30 DEG C to be retrograded for 24 h, then taken out and subjected to centrifugal separation for 10-15 min, a substrate in a centrifuge tube is washed and then dried for 12 h, and the starch microspheres with the average particle sizes smaller than 10 mu m are obtained. The prepared starch microspheres have the characteristic of being small in particle size, the phenomenon that starch microspheres aggregate due to the fact that the interfacial area between the two phases of the aqueous two-phase emulsion is substantially increased, the interfacial free energy is substantially increased and liquid drops aggregate to reduce the interfacial free energy in the preparation process of the starch microspheres can be avoided, and the preparation method has great application value.

Description

[0001] 【Technical Field】 [0002] The invention relates to the field of preparation of starch microspheres, in particular to a method for preparing small-diameter starch microspheres. [0003] 【Background technique】 [0004] Macromolecular microspheres refer to macromolecular materials with a particle size in the micron or sub-micron range and a spherical or quasi-spherical shape. In recent years, the research and application of polymer microspheres have developed rapidly, and have entered various fields of social life, from high value-added products such as drug carriers and chromatography media to bulk products such as coatings, paper surface coatings, and cosmetics. All polymer microspheres are used. Particle size is one of the important indicators of polymer microspheres. According to the particle size, they can be divided into small particle size microspheres (particle size <20μm) and large particle size microspheres (particle size ≥20μm). The particle size directly affects...

AI Technical Summary

Problems solved by technology

However, in the existing reports, the average particle size of starch microspheres prepared by the aqueous two-phase emulsion method is large and the distribution is uneven, and there is no report on the preparation of small-size starch microspheres by the aqueous two-phase emulsion method.

The applicant found in the preliminary research that, if drawing lessons from the process of preparing small-diameter starch microspheres by the W / O emulsion method, using high-energy emulsification equipment such as a high-shear emulsifier to directly treat the existing starch-polyethylene glycol If the aqueous two-phase emulsion is processed, the prepared starch microspheres will be seriously agglomerated, and the product quality will be poor.

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